Nivolumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Korean Patients with HER2-Negative, Untreated, Unresectable Advanced or Recurrent Gastric or Gastroesophageal Junction Cancer: Subgroup Analysis of a Randomized, Multicenter, Double-Blind Phase 3 Trial (ATTRACTION-4) [0.03%]
纳武单抗联合化疗对比安慰剂联合化疗用于HER2阴性、不可切除的晚期或复发胃癌或 gastroesophageal junction 癌症韩国患者的疗效：一项随机双盲III期临床试验（ATTRACTION-4）亚组分析
Yoon-Koo Kang,Min-Hee Ryu,Do-Youn Oh et al.
Yoon-Koo Kang et al.
Purpose: We report the safety and efficacy of nivolumab + chemotherapy for first-line treatment of advanced or recurrent gastric or gastroesophageal junction cancer in the Korean subpopulation of the ATTRACTION-4 clinical...
HER3 Expression and PIK3CA Mutational Status Predict Pathological Response of Neoadjuvant Therapy in HER2 Positive Breast Cancer Patients [0.03%]
HER3表达和PIK3CA突变状态可预测HER2阳性乳腺癌新辅助治疗的病理反应
Xi Xia,Zhiqiang Zong,Jian Shen et al.
Xi Xia et al.
Purpose: The main purpose of this study is to explore the predictive value of HER3 expression level and PIK3CA mutation for the efficacy of neoadjuvant therapy in HER2 positive breast cancer patients. ...
Anticancer Treatment Influences TREM2 in Tumor-Associated Macrophages in Lung Cancer [0.03%]
肺癌抗肿瘤治疗影响肺癌相关巨噬细胞上的TREM2
Yoon Jin Cha,Eun Hye Lee,Chi Young Kim et al.
Yoon Jin Cha et al.
Purpose: The triggering receptor expressed on myeloid cells (TREM2) creates an immunosuppressive environment, but the effects of anticancer treatment on TREM2 and the tumor microenvironment (TME) are not well established....
Uncovering Putative Causal Non-Coding RNAs in Acute and Chronic Myeloid Leukemia: A Genome-Wide Mendelian Randomization Study [0.03%]
急性髓系白血病和慢性髓系白血病潜在的因果非编码RNA的全基因组孟德尔随机化研究
Sunwoo Jung,Ji-Won Kim,Buhm Han
Sunwoo Jung
Purpose: Although non-coding RNAs (ncRNAs) have often been implicated in various cancers, their causal roles in acute (AML) and chronic myeloid leukemia (CML) remain unclear. Here, we conducted a genome-wide two-sample Me...
Insomnia, Pain, and Pain-Related Dysfunctional Beliefs About Sleep among Patients with Cancer [0.03%]
癌症患者的失眠、疼痛以及与疼痛相关的睡眠功能障碍信念
Seockhoon Chung,Soobeen Lee,Mohd Ashik Shahrier et al.
Seockhoon Chung et al.
Purpose: We explored the reliability and validity of the Pain-related Beliefs and Attitudes about Sleep (PBAS) scale among patients with cancer. Further, we compared the usability of the PBAS scale with that of the Cancer...
Advances in T-Cell-Directed Immunotherapy for Adult Mature B-Cell Lymphoma: A Comprehensive Review of CAR T-Cell and Bispecific Antibody Therapies [0.03%]
针对成人成熟B细胞淋巴瘤的T细胞免疫治疗进展：嵌合抗原受体T细胞和双特异性抗体疗法的全面综述
Jinchul Kim,Seok Jin Kim
Jinchul Kim
B-cell lymphomas are a heterogeneous group of malignancies with a high relapse rate after conventional therapies. T-cell-mediated immunotherapies, notably chimeric antigen receptor (CAR) T-cell therapies and T-cell-engaging bispecific antib...
Efficacy and Safety of Ropeginterferon Alfa-2b in Low-Risk Polycythemia Vera [0.03%]
低危真性红细胞增多症患者中罗匹干扰素α-2б的疗效和安全性研究
Ji Yun Lee,Sung-Soo Yoon,Deok-Hwan Yang et al.
Ji Yun Lee et al.
Purpose: Conventional management of low-risk polycythemia vera (PV), consisting of phlebotomy and aspirin, often fails to adequately control symptoms and hematologic parameters. This study evaluated the efficacy and safet...
Adjuvant Pembrolizumab Versus Placebo for Renal Cell Carcinoma in the East Asian Subgroup of the Phase 3 KEYNOTE-564 Study [0.03%]
KEYNOTE-564研究的东亚亚组肾细胞癌辅助帕博利尤单抗 versus 安慰剂的III期疗效分析
Se Hoon Park,Yen-Hwa Chang,Jae Lyun Lee et al.
Se Hoon Park et al.
Purpose: Adjuvant pembrolizumab improved disease-free survival (DFS) and overall survival (OS) versus placebo in participants with renal cell carcinoma (RCC) at increased risk of recurrence after nephrectomy in the global...
NOVA1 Activation Modulates the Tumor Immune Microenvironment Through STING Phosphorylation in Head and Neck Squamous Cell Carcinoma [0.03%]
NOVA1活化通过STING磷酸化调节头颈鳞状细胞癌的肿瘤免疫微环境
Sehui Kim,Hyang Mi Kim,Jae Min Bae et al.
Sehui Kim et al.
Purpose: Neuro-oncological ventral antigen 1 (NOVA1), a neuron-specific pre-mRNA splicing factor, is involved in neuronal development and oncogenesis. NOVA1 overexpression is associated with favorable prognosis in head an...
Association between Obesity and Melanoma Risk in an Asian Population: A Nationwide Cohort Study [0.03%]
东亚人群肥胖与黑色素瘤风险的队列研究
Hye Yeon Koo,Kyungdo Han,Jihye Park et al.
Hye Yeon Koo et al.
Purpose: Previous studies from mostly Western populations have suggested possible associations between obesity and melanoma risk. This study aimed to investigate associations between obesity status and melanoma using a na...