Disease Burden and Treatment Pattern of Advanced or Recurrent Endometrial Cancer in Korea: A Nationwide Database (DIRECTION) Study [0.03%]
韩国晚期或复发性子宫内膜癌的疾病负担和治疗模式：一项全国数据库（DIRECTION）研究
Hyun-Woong Cho,Se Ik Kim,Min-Ji Bae et al.
Hyun-Woong Cho et al.
Purpose: Advanced/recurrent endometrial cancer (EC) patients has a poor prognosis, with higher recurrence and mortality than early-stage. However, as the real-world disease burden in these patients remains unclear, we aim...
WNT3A Upregulates the RIP1/HIF-1α/GDF-15 Pathway to Induce EMT and Thereby Increase Colorectal Cancer Cell Migration and Invasion [0.03%]
WNT3A通过上调RIP1/HIF-1α/GDF-15通路诱导上皮间质转化从而促进结直肠癌细胞迁移和侵袭
A-Ram Kang,Tae-Jun Kim,Jung-Yoon Yoo et al.
A-Ram Kang et al.
Purpose: We previously demonstrated that WNT signaling, a key regulator of epithelial-mesenchymal transition (EMT), promotes malignancy via RIP1 in colorectal cancer (CRC). In this study, we aimed to reveal the novel sign...
Prognostic Impact of Organ-Specific Metastasis in Non-Small-Cell Lung Cancer [0.03%]
非小细胞肺癌器官特异性转移的预后影响
Woo Kyung Ryu,Munkhtsatsral Ganbaatar,Nuri Park et al.
Woo Kyung Ryu et al.
Purpose: Prognostic stratification is essential in non-small-cell lung cancer (NSCLC) to guide treatment decisions. While the TNM staging system has evolved to refine the M category based on metastatic burden, it does not...
Excess Cholesterol Biosynthesis by Up-Regulated HMGCS1 in Colorectal Cancer Cells Induced M2-Like Tumor-Associated Macrophage Polarization Via Extracellular Vesicles [0.03%]
结肠癌细胞通过上调HMGCS1促进胆固醇过量合成，导致M2型肿瘤相关巨噬细胞极化 via extracellular vesicles
Liu Yang,Bo Wu,Tingyi Sun et al.
Liu Yang et al.
Purpose: The aetiology of colorectal cancer (CRC) is attributed to the intrinsic malignant cell transformation and the extrinsic tumor microenvironment (TME). Within the TME, M2-like tumor-associated macrophages (TAMs) pl...
Real World Efficacy of 1st-Line Nivolumab Plus Ipilimumab and its Practical Predictive Biomarkers in Advanced Renal Cell Carcinoma: First Analysis from RENOIR Study (KCSG GU22-13) [0.03%]
一项关于肾细胞癌一线使用纳武利尤单抗联合伊匹木单抗真实世界疗效及其实践预测生物标志物的第一分析：RENOIR研究(KCSG GU22-13)结果
Jwa Hoon Kim,Sang Joon Shin,Woo Kyun Bae et al.
Jwa Hoon Kim et al.
Purpose: We investigated the real-world efficacy of first-line nivolumab plus ipilimumab (NI) and its predictive clinicopathological biomarkers in patients with advanced renal cell carcinoma(aRCC). ...
Impact of Occupational Lead Exposure on Lung Cancer Risk in Korean Male Workers: A Retrospective Cohort Study [0.03%]
韩国男性工人职业铅暴露与肺癌风险的关联研究：一项回顾性队列研究
Kyung-Eun Lee,Sanggil Lee,Jin-Ha Yoon et al.
Kyung-Eun Lee et al.
Purpose: In 2006, the IARC reported that inorganic lead is carcinogenic in animals but with limited evidence in humans. In addition, some studies have reported that exposure to lead increases the risk of lung cancer, but ...
Effects of Exercise Interventions on Breast Cancer Patients During Adjuvant Therapy: A Systematic Review and Meta-Analysis [0.03%]
运动干预对乳腺癌患者辅助治疗期间影响的系统评价和 meta 分析
Zhiyuan Sun,Tengteng Han,Lianshi Feng et al.
Zhiyuan Sun et al.
Purpose: Exercise can enhance the therapeutic effects of adjuvant medications, improve both physiological and psychological functions, and increase physical fitness among breast cancer patients receiving adjuvant therapy....
LRRC15 Promotes the Development of Breast Cancer by Regulating Autophagy through the PI3K/AKT/mTOR Signaling Pathway [0.03%]
LRRC15通过PI3K/AKT/mTOR信号通路调节自噬从而促进乳腺癌发生发展
Xinru Fan,Liu Gao,Zheng Zhang et al.
Xinru Fan et al.
Purpose: Leucine-rich repeats (LRR) play important roles in tumorigenesis and may serve as novel biomarkers for cancer therapy. The expression of leucine-rich repeat-containing protein 15 (LRRC15) is increased in several ...
Extracellular Vesicle-Derived Adenosine as a Diagnostic Metabolic Biomarker for Pancreatic Ductal Adenocarcinoma [0.03%]
外泌体衍生的腺苷作为胰腺导管腺癌的诊断代谢生物标志物
Tao Xia,Wenhui Ouyang,Jie Wang et al.
Tao Xia et al.
Purpose: Current non-invasive diagnostic tools for pancreatic ductal adenocarcinoma (PDAC) exhibit limited sensitivity and specificity. This study aimed to identify more accurate plasma biomarkers by profiling extracellul...
IFITM1 Influences Natural Killer Cell-Mediated Cytotoxicity by Modulation of HLA class I Expression in Triple-Negative Breast Cancer Cells [0.03%]
干扰素诱导的跨膜蛋白(IFITM1)通过调节三阴性乳腺癌细胞HLA-I分子表达影响自然杀伤(NK)细胞毒性作用
Heejin Lee,Chanyeon Park,Keunsoo Kang et al.
Heejin Lee et al.
Purpose: Interferon-induced transmembrane protein 1 (IFITM1) is associated with a poor prognosis in triple-negative breast cancer (TNBC); however, the mechanisms by which IFITM1 contributes to oncogenesis in TNBC are uncl...