Real-World Shelf Life of Adrenaline Auto-Injectors at Pharmacies in Denmark, Finland, Sweden, and Norway [0.03%]
丹麦、芬兰、瑞典和挪威药房肾上腺素自动注射器的实际货架寿命分析
Jesper Nørregaard,Christoffer Mertz,Anne Danø et al.
Jesper Nørregaard et al.
There is a well-documented gap between the prescription of adrenaline auto-injectors (AAIs) and their real-world use during anaphylaxis. Although several aspects of AAI underuse have been investigated, the potential role of shelf life in in...
Impact of Market Access Delays on Time to Patient Access: Multi-Country Comparative Analysis Assessing the First Commercial Launch Indications for Five Oncology Medicines Across Europe and Canada [0.03%]
市场准入延迟对患者用药时间影响的多国比较分析——从欧洲和加拿大五种抗癌药物首次商业上市适应症入手的研究
Barry Crean,David Parry,Alison Horsfield et al.
Barry Crean et al.
Background: The benefit of pharmaceutical innovation manifests when patients access treatment. Following regulatory approval in Europe and Canada, reimbursement decisions depend on health technology assessments (HTAs), which can be prolonge...
Introducing an Expanded Value Framework in Health Technology Assessment of Vaccines [0.03%]
扩大健康技术评估中疫苗价值框架的应用
Farzaneh Eslami,Thi Hao Pham,Angga P Kautsar et al.
Farzaneh Eslami et al.
Health Technology Assessment (HTA) frameworks increasingly recognize the broader value elements of vaccines; however, their adoption remains inconsistent across jurisdictions and often incomplete in practice. Many HTA processes continue to ...
When Do Annuity-Based Payments Help to Address the Affordability Challenge of Funding Advanced Therapies? Insights from a Budget Impact Simulation [0.03%]
年金-based支付何时有助于解决资助先进疗法的可承受性挑战？预算影响模拟的启示
Walter Van Dyck,Sissel Michelsen,David Veredas et al.
Walter Van Dyck et al.
Spreading payments over time by means of annuities has been proposed as a means to address the affordability challenge of funding very expensive advanced therapies, especially within managed entry agreements. This study aims to examine when...
Household Out-of-Pocket Burden Costs for Pediatric Pneumonia in Low- and Middle-Income Countries: Evidence Review and Econometric Framework [0.03%]
低收入和中等收入国家儿童肺炎的家庭自付费用负担：证据回顾及经济计量框架
Ioannis Smaraidos,Maria Kyrmanidou,Asterios Kampouras
Ioannis Smaraidos
Pediatric pneumonia remains a major cause of morbidity and mortality in low- and middle-income countries (LMICs), imposing both health and financial burdens. While the clinical aspects of pediatric pneumonia are well-studied, less attention...
Accessibility of Biologic Drugs in Morocco: Comparison with FDA and EMA Approvals (2015-2025) [0.03%]
摩洛哥生物药的可及性：与FDA和EMA的审批情况进行比较(2015-2025年)
Mounir Charrak,Yahia Cherrah,Samira Serragui
Mounir Charrak
This study aims to evaluate the rates and timeframes of the availability and reimbursement of biologic drugs in Morocco, after approval by the Food and Drug Administration (FDA) or the European Medicines Agency (EMA). The results will help ...
Mapping the Use of Real-World Evidence Across the EU Health Technology Assessment Regulation: Methodological Considerations, Challenges, and Opportunities for Harmonization [0.03%]
欧盟卫生技术评估条例中真实世界证据使用情况的考察：方法学考虑因素、挑战与协调机会分析
Grammati Sarri,Bengt Liljas,Keith R Abrams et al.
Grammati Sarri et al.
Methodological guidelines for real-world evidence (RWE) in European Union (EU) joint clinical assessments (JCA) are lacking. This manuscript explores RWE potential in EU health technology assessment (HTA) and offers recommendations for gene...
When Activism Becomes Survival: The Mental Health Costs of Constant Resistance in the Digital Era in the Balkans-A Health Policy Perspective [0.03%]
当反抗成为生存手段时——从卫生政策角度看巴尔干地区数字时代抗争的代价及对精神健康的影响
Aleksandar Sič,Svetozar Mijuskovic,Nebojsa Brezic
Aleksandar Sič
Activism exposes individuals to sustained harassment, threat and psychological strain in contexts marked by discrimination and weak institutional protection. For LGBTQ communities, public engagement frequently increases vulnerability to bot...
Cost-Effectiveness of 3D-Printed Patient-Specific Versus Off-the-Shelf Interbody Cages in Lumbar Spinal Fusion: A Markov Model Cost-Utility Analysis [0.03%]
基于患者的3D打印融合椎间植入物与现成的融合椎间植入物在腰椎融合术中的成本效益分析：马尔可夫模型成本效用分析
Jackson C Hill,Ralph J Mobbs,Marc Coughlan et al.
Jackson C Hill et al.
The aim of the present study was to compare the cost-effectiveness of 3DMorphic's spinal 3DFusion Lumbar (3DFL) cages versus Off-The-Shelf (OTS) cages for patients undergoing lumbar interbody fusion in an Australian healthcare setting. 3DFL...
Comparative Cost Evaluation of Managed Entry Agreement Techniques Using Real-World Data from High-Cost Anticancer Drugs in Thailand [0.03%]
使用高成本抗癌药物的真实世界数据评估管理准入协议技术的比较成本效果分析
Piyapat Owat,Chaoncin Sooksriwong,Hataiwan Ratanabunjerdkul et al.
Piyapat Owat et al.
High-cost innovative anticancer drugs pose challenges for health systems in balancing timely patient access with long-term financial sustainability. In Thailand, reliance on Health Technology Assessment for reimbursement decisions may delay...