Porphyromonas gingivalis OMVs inhibit osteogenic differentiation of BMSCs via SAA3/TLR4/MyD88/NF-κB axis [0.03%]
牙龈卟啉单胞菌外膜囊泡通过SAA3/TLR4/MyD88/NF-κB轴抑制骨髓间充质干细胞成骨分化
Yongyong Yan,Haiyan Wang,Huizhi Deng et al.
Yongyong Yan et al.
Backgrounds: Periodontitis-induced alveolar bone loss is a primary cause of tooth loss. Porphyromonas gingivalis (P. gingivalis) is the primary pathogenic bacterium of periodontitis. Outer membrane vesicles (OMVs) derived...
Microbial manipulators: Fusobacterium nucleatum modulates the tumor immune microenvironment in colorectal cancer [0.03%]
微调免疫：Fusobacterium nucleatum通过调节肿瘤免疫微环境促进结直肠癌发展
Qian Li,Wanyi Luo,Li Xiao et al.
Qian Li et al.
Fusobacterium nucleatum, a microorganism ordinarily detected in the oral cavity, is considered as a pathobiont related to periodontitis and a range of human diseases, including colorectal cancer (CRC). The dynamics of how F. nucleatum encou...
Altered oral microbiome composition in mental disorders: a systematic review and meta-analysis [0.03%]
精神障碍中口腔微生物群组成的改变：系统评价和meta分析
Dingxin Cao,Jun Yang,Yiwen He et al.
Dingxin Cao et al.
Introduction: Emerging research underscores the gut-brain axis in mental disorder pathophysiology, yet the oral microbiome's contribution to mental health remains underexplored. Elucidating oral microbial signatures in me...
Single-cell RNA sequencing using split-pool barcoding reveals transcriptional heterogeneity in Porphyromonas gingivalis with implications for periodontal pathogenesis [0.03%]
利用分池条形码单细胞RNA测序揭示齿龈密螺旋体转录异质性及其对牙周病发病机制的影响
Eun-Young Jang,Seok Bin Yang,Jeewan Chun et al.
Eun-Young Jang et al.
Background: Porphyromonas gingivalis is a keystone pathogen in periodontitis, associated with dysbiosis and chronic inflammation. While its virulence mechanisms are well characterized, its transcriptional heterogeneity at...
Digital PCR outperforms quantitative real-time PCR for the detection and quantification of major periodontal pathobionts [0.03%]
数字PCR检测和量化主要牙周病病原体的性能优于定量实时PCR
Haris Munjaković,Katja Povšič,Mario Poljak et al.
Haris Munjaković et al.
Background: This study comparatively evaluated the analytical and diagnostic performance of a multiplex digital polymerase-chain reaction (dPCR) assay and a quantitative real-time PCR (qPCR) for the simultaneous detection...
d-Histidine inhibits Streptococcus mutans growth as a potential anti-caries agent [0.03%]
D-组氨酸通过抑制变异链球菌生长发挥防龋作用
Liuchang Yang,Yuxing Chen,Yaqi Chi et al.
Liuchang Yang et al.
Background: Dental caries is a bacterial-mediated infectious disease that affects the hard tissues of the tooth, with Streptococcus mutans being the primary cariogenic pathogen due to its robust biofilm-forming ability. C...
Dextranase enhances nanoparticle penetration of S. mutans biofilms [0.03%]
果胶酶增强S. mutans生物膜中纳米粒子的渗透能力
D S DeCesaris,Michael A L Hayashi,M M Vickerman et al.
D S DeCesaris et al.
Background/objective: Cariogenic biofilms possess a rich extracellular polysaccharide (EPS) matrix, which can reduce the penetration of anticaries agents such as nanoparticle-based technologies. The aim of this study was ...
The pharmacokinetics of hexylresorcinol-containing lozenges and their antimicrobial efficacy against oral and respiratory microorganisms [0.03%]
含己基 resorcinol 胶囊的药代动力学及其对口腔和呼吸道微生物的抗菌功效
Priyanka Sharma,Charlotte Richards,Jennifer Y M Adams et al.
Priyanka Sharma et al.
Background: Hexylresorcinol (HR) lozenges provide symptomatic relief for sore throats. Despite its recognised anaesthetic and antiseptic properties, evidence of HR bactericidal activity in these formulations is limited, b...
Microbiome variability and role of Candida albicans in site-specific dental plaques in orthodontic adolescent patients with white spot lesions [0.03%]
正畸患者的白色斑块患者特定牙位牙菌斑的菌群变异性和白念珠菌的作用
Hao Yang,Hongyu Gao,Xianju Xie et al.
Hao Yang et al.
White spot lesions (WSLs) are a common complication of orthodontic treatment. However, the cariogenic discrepancy in the supragingival microbiome between demineralized and non-demineralized surfaces and the influence of Candida albicans ass...
Enhanced dominance of nitrate-reducing bacteria using a combination of nitrate and erythritol in in vitro cultured oral biofilm [0.03%]
使用硝酸盐和赤藓糖醇的组合在体外培养口腔生物膜中增强硝酸盐还原菌的优势地位研究
Akihiko Fujii,Tomoki Akatsu,Hatsumi Souno et al.
Akihiko Fujii et al.
Background: Oral nitrate-reducing bacteria are associated with good oral health, with inorganic nitrate specifically promoting the growth of these beneficial bacteria. Sugar alcohols affect the composition of oral microbi...