Overcoming Gastric Barriers for Oral Peptide Delivery: QbD-Based Development of Sodium Caprate-Enabled Tirzepatide Tablets [0.03%]
基于QbD的开发：利用月桂酸钠 enabled tirzepatide片剂口服递送肽类药物克服胃屏障
Seokhyun Im,Ji-Yoon Lee,Joo-Eun Kim
Seokhyun Im
Background/Objectives: Tirzepatide is a dual GIP and GLP-1 receptor agonist indicated for the treatment of type 2 diabetes and obesity. Oral delivery of tirzepatide is limited by poor gastrointestinal permeability, pH-dependent solubility, ...
Sohail Mumtaz,Juie Nahushkumar Rana,Kainat Gul
Sohail Mumtaz
Background/Objectives: Curcumin shows broad anticancer activity but limited clinical success as a standalone agent because of poor bioavailability and inconsistent tumor exposure. This review introduces the concept of curcumin as a molecula...
Beyond Body Weight: A Comprehensive Review of Allometric Scaling in Drug Development for Human Dose Predictions [0.03%]
超越体重：药物开发中的人体剂量预测的全尺度Scaling综合回顾
Marlon C Mallillin rd,Daniela A Silva,Neil A Miller et al.
Marlon C Mallillin rd et al.
Allometric scaling provides a practical framework for predicting human pharmacokinetic (PK) parameters from animal data by relating physiological processes to body size through power-law equations. Despite its simplicity and widespread use ...
Quality by Design Approach to the Optimization of Cohesive Powder Blending in Direct Compression [0.03%]
基于质量设计的直接压片工艺中粉体混合优化研究
Mateusz Przywara,Patryk Leszczak
Mateusz Przywara
Background/Objectives: Direct compression of cohesive powders is often challenged by poor flow, blend heterogeneity, and variable tablet quality. This study investigated how mixing time, fill level, and rotational speed affect the blending ...
Promising Glaucoma Medication: A Comprehensive Translational Evaluation [0.03%]
全面的转化评价 promising 的青光药物 medication
Doaa Nabih Maria,Mohamed Moustafa Ibrahim,Sara N Maria et al.
Doaa Nabih Maria et al.
Background/Objectives: Despite available treatment options, glaucoma continues to be a leading cause of irreversible blindness. Current medications have multiple limitations, including rapid drainage, ocular irritation, requirement for mult...
Beyond Antibiotics: The Role of Antimicrobial Polymers in Modern Therapeutics [0.03%]
超越抗生素：抗菌聚合物在现代治疗中的作用
Martina Appignani,Giovanni Corfiati,Lisa Marinelli et al.
Martina Appignani et al.
Antimicrobial polymers are a potential and viable alternative to antibiotic therapies, whose effectiveness is increasingly compromised by the onset of antimicrobial resistance and antibiotic persistence. Antimicrobial polymers also have pot...
Natural Polymer-Based Hemostatic Hydrogels with Advanced Material and Structural Designs for Functional Applications [0.03%]
具有高级材料和结构设计的天然聚合物基止血水凝胶的功能应用
Lixin A,Zhaoming Guo,Chen Zhao et al.
Lixin A et al.
Uncontrolled hemorrhage remains a major challenge in trauma care and surgical interventions, where rapid hemostasis and wound sealing are essential for improving patient survival. Natural polymer-based hydrogels have emerged as promising he...
Tablet Compression and Performance of Artocarpus altilis as a Starch-Rich Natural-Source Excipient with Different APIs [0.03%]
Artocarpus altilis作为富含淀粉的天然辅料与不同活性成分的 tablet压缩性能研究
Luis F Torrens-Sotomayor,Carlos Velázquez-Figueroa
Luis F Torrens-Sotomayor
Background/Objectives: Excipients play a key role in the manufacturability and performance of solid oral dosage forms, particularly for drug candidates with diverse solubility, permeability, and mechanical properties. Understanding excipien...
Assessment of Flexible Dosing Volumes in an Existing Spring-Driven Autoinjector Platform [0.03%]
评估现有弹簧驱动自动注射器平台的灵活剂量体积能力
Rozhin Derakhshandeh,Javad Eshraghi,Pavlos P Vlachos et al.
Rozhin Derakhshandeh et al.
Background: Flexibility in dosing volume within an autoinjector platform is critical for streamlining product development, enabling dose adjustments without altering concentration. This study presents a framework to evaluate the capability ...
Establishment and Optimization of a Human Flow-Based Hollow Fiber In Vitro Blood-Brain Barrier Model for Systemic Inflammatory Responses [0.03%]
基于人群流动的体内空心纤维血脑屏障模型的建立与优化用于全身炎症反应
Anna Gerhartl,Maria Kirchsteiger,Andreas Brachner et al.
Anna Gerhartl et al.
Background/Objectives: Systemic inflammation and circulating proinflammatory cytokines can impair blood-brain barrier (BBB) integrity. Many in vitro BBB models lack the complexity to fully recapitulate systemic inflammation and its long-ter...