Synergistic Cancer Immunotherapy by Inducing Immunogenic Cell Death and Blocking the CD39-Adenosine Pathway Using a Nanoplatform [0.03%]
一种用于诱导免疫原性细胞死亡并利用纳米平台阻断CD39-腺苷途径的协同癌症免疫疗法
Yiwen Liu,Xiaoyu Pang,Lin Li et al.
Yiwen Liu et al.
Background: The immunosuppressive tumor microenvironment (TME), driven by the CD39-mediated conversion of immunostimulatory ATP to immunosuppressive adenosine (ADO), limits cancer immunotherapy. Research design and methods: Here, we develop...
The Changing Landscape of Advanced Drug Delivery: From Passive Carriers to Intelligent Therapeutic Platforms [0.03%]
从被动载体到智能治疗平台：高端药物递送的变革之路
Milena A Vega,Carlos Alonso
Milena A Vega
The development of drug delivery systems (DDSs) has traditionally been driven by the need to overcome well-recognized pharmacokinetic limitations, including poor aqueous solubility, rapid degradation of therapeutic agents, low bioavailabili...
Predicting pH-Dependent Solubility Enhancement and Precipitation Suppression in Drug-Cyclodextrin-Arginine Formulations [0.03%]
预测药物-环糊精-精氨酸配方中的pH依赖性溶解度增强和沉淀抑制现象
Natalia Bolocan,Igor Povar,Alina Catrinel Ion et al.
Natalia Bolocan et al.
Background/Objectives: Cyclodextrin-based ternary systems are widely used to improve the solubility of poorly soluble drugs. Amino acids such as L-arginine may further increase dissolved drug concentrations and reduce precipitation under ph...
Formulation Design of Amiodarone Hydrochloride Tablets Optimized for a Continuous Manufacturing Process [0.03%]
优化连续生产流程的盐酸胺碘酮片剂处方设计
Ju-Hyun Yoon,Chae-Won Jeon,Young-Joon Park et al.
Ju-Hyun Yoon et al.
Background: Amiodarone hydrochloride is an antiarrhythmic agent, primarily classified as a Vaughan Williams Class III antiarrhythmic agent, used for the treatment and prevention of arrhythmia and designated as an essential national drug. Re...
Short-Chain Oleanolic Acid Esters and Furoyl Hybrids: Pharmacological Prediction, ADMETox Profiling, In Vitro Cytotoxicity Evaluation, Antioxidant Testing and EGFR Docking [0.03%]
短链熊果酸酯和呋喃酰杂化物：药理预测，ADMET分析，体外细胞毒性和抗氧化测试以及EGFR对接研究
Barbara Bednarczyk-Cwynar,Piotr Ruszkowski,Maciej Kulawik et al.
Barbara Bednarczyk-Cwynar et al.
Background/Objectives: This study aimed to improve the biological profile of oleanolic acid (OA) through structural modification at the C-17 carboxyl group and the C-3 hydroxyl group, with a focus on the design of short-chain alkyl esters a...
Protein-Based Nanomaterials for Cancer Therapy: A Comparative and Translational Perspective [0.03%]
癌症治疗的蛋白质基纳米材料：比较和转化视角
Juan Gonzalez-Valdivieso,Javier Gutiérrez,Jonathan Alexander Vásquez Calero et al.
Juan Gonzalez-Valdivieso et al.
Over the past decade, the use of nanomaterials and nanomedical devices has been increasingly explored for cancer treatment. Although the outcomes of conventional therapies have improved patient survival, these approaches still present impor...
Punctal and Intracanalicular Drug Delivery Systems for Ophthalmic Use: A Narrative Review of Technologies, Clinical Outcomes, and Critical Quality Attributes [0.03%]
眼科用药的结膜湖和管内给药系统：技术、临床结果及关键质量属性的叙事综述
Elena O Bakhrushina,Kseniia S Leonova,Nikita O Belyavsky et al.
Elena O Bakhrushina et al.
Background: Conventional ophthalmic eye drops have low bioavailability (80% over 4 weeks), swelling degree (30-60%), controlled burst release (
Preclinical Pharmacokinetics of a Triple-Combination Intravaginal Ring for HIV Prevention [0.03%]
一种用于HIV预防的三联组合阴道环的药代动力学生物学研究
John A Moss,Priya Srinivasan,Irina Butkyavichene et al.
John A Moss et al.
Background/Objectives: The prevention of sexual HIV-1 acquisition in women and girls in sub-Saharan Africa remains an important public health priority. Expanding the existing biomedical product portfolio to include long-acting vaginal produ...
Piperine-Loaded Nanoparticles: In Vitro Evaluation of a Botanical Nanoixodicide Against Rhipicephalus microplus and Amblyomma mixtum Larvae Resistant to Conventional Treatments [0.03%]
胡椒碱纳米颗粒：一种针对常规治疗方法耐药的Rhipicephalus microplus和Amblyomma mixtum幼虫的植物源性纳米驱蜱剂的体外评价
Romario García-Ponce,José Pablo Villarreal-Villarreal,Rocío Álvarez-Román et al.
Romario García-Ponce et al.
Background/Objectives: Tick infestations represent a major economic problem for livestock farming due to the hematophagous nature of these parasites and their crucial role as vectors of pathogens. The prolonged use of synthetic chemical ixo...
From Concept to Clinic: Vepdegestrant (ARV 471) Becomes the First Approved PROTAC Drug [0.03%]
从概念到临床：口服蛋白降解剂Vepdegestrant（ARV-471）成为首个获批的PROTAC药物
Miklós Bege,Miklós Lovas,Anikó Borbás
Miklós Bege
Breast cancer (BC) is a major global public health problem. Classical therapies have limited success on the treatment of BC; therefore, new therapeutic options are needed. Proteolysis targeting chimeras (PROTACs) are heterobifunctional mole...