Clinical and Pharmacogenetic Factors Associated with Response to JAK Inhibitors in Patients with Rheumatoid Arthritis: A Real-World Study of JAK1, JAK2, and JAK3 Gene Variants [0.03%]
与类风湿关节炎患者JAK抑制剂反应相关的临床和药物基因组学因素：JAK1、JAK2 和 JAK3 基因变异的现实世界研究
Alicia Martín Roldán,Noelia Márquez Pete,María Del Mar Sánchez Suárez et al.
Alicia Martín Roldán et al.
Background: Janus kinase inhibitors (JAK inhibitors) have expanded therapeutic options for rheumatoid arthritis (RA), although factors associated with treatment response in routine clinical practice remain incompletely defined. Objectives: ...
Artificial Intelligence-Driven Nanomedicine: From Drug Formulation and Nanocarrier Design to Clinical Translation [0.03%]
人工智能驱动的纳米医药：从药物配方和纳米载体设计到临床转化
Abdulrahman A Alsaqabi,Abdulaziz A Almoutairi,Faisal Alnehari et al.
Abdulrahman A Alsaqabi et al.
The integration of artificial intelligence (AI) and machine learning (ML) is fundamentally transforming pharmaceutical sciences, shifting drug formulation and nanocarrier design from traditional empirical approaches toward predictive, data-...
Ana Clara Santiago Bastos,Arissa De Oliveira Sato,Luana Carvalho de Oliveira et al.
Ana Clara Santiago Bastos et al.
Medicinal cannabis has gained increasing attention from both the scientific community and clinical practice, due to the therapeutic potential of its major phytocannabinoids, particularly cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC),...
Dual-Functional Gel-Based Delivery of Chitosan-Coated Gold Nanoparticles for Accelerated Bone Healing in Defect Models [0.03%]
壳聚糖修饰的金纳米颗粒双功能凝胶负载体系促进骨缺损修复的功能研究
Noha M Badawi,Shereen Nader Raafat,Mohamed M Kataia et al.
Noha M Badawi et al.
Background: Effective management of bone defects remains a major clinical challenge, driving continuous efforts to develop bioactive, localized delivery systems that support bone regeneration. Gold nanoparticles (AuNPs) have gained attentio...
Exploiting the T790M Gatekeeper: A Theoretical Blueprint for Non-Covalent Inhibition of in cis Triple-Mutant EGFR [0.03%]
利用T790M守门人蛋白：非共价抑制顺式三联突变EGFR的理论蓝图
Shrikant S Nilewar,Shuvadip Khanra,Manav Pandya et al.
Shrikant S Nilewar et al.
Background/Objectives: The EGFR T790M mutation drives lung cancer resistance by sterically hindering inhibitors and restoring ATP affinity. As C797S mutations render covalent inhibitors obsolete, novel non-covalent strategies are critical. ...
In Vitro Antitumor Properties of Simvastatin-Loaded SBA-16 Mesoporous Nanoparticles Using Two- and Three-Dimensional Colorectal Spheroid Models [0.03%]
西立伐他汀-载SBA-16介孔纳米颗粒的体外抗肿瘤性质：二维和三维结直肠球形模型实验研究
Akram J Kadhim,Ibrahim Tawfiq,Mohamed El-Tanani et al.
Akram J Kadhim et al.
Background/objectives: Colorectal cancer (CRC) remains a cause of cancer-related mortality worldwide, with therapeutic progress hindered by poor tumor selectivity and acquired drug resistance. This study investigated the anticancer efficacy...
Multidimensional Modification and Functional Optimization of Melittin: From Natural Toxic Peptide to Safe and Effective Therapeutics [0.03%]
蜂毒肽的多维度改造与功能优化：从天然毒性多肽到安全有效药物疗法
Zhengyu Chen,Chunli Su,Tianyao Guo et al.
Zhengyu Chen et al.
Melittin, a cationic amphipathic 26-residue peptide from bee venom, displays broad-spectrum antibacterial, antitumor and anti-inflammatory activities, yet severe hemolysis, poor cell selectivity, rapid plasma degradation and high immunogeni...
Natural Macromolecules as Building Blocks for Microcapsule Formation in Drug Delivery [0.03%]
基于药物传输的微胶囊形成的天然大分子构建模块
Isidora Lajevec,Nebojša Pavlović,Dejan Ćirin et al.
Isidora Lajevec et al.
Background/Objectives: Microcapsules are particles 1-1000 µm in size, with a core containing the active substance (in liquid, solid, or gaseous state) and a shell typically composed of natural, synthetic, or semi-synthetic polymers. Althou...
Tailored Drug Release with Improved Solubility via Spray Drying and Functional Ready-to-Fill Capsules [0.03%]
通过喷雾干燥和功能即填胶囊改善溶解度的定制药物释放
Kristina Vlahovic,Lilla Dorottya Kóró,Bence Dávid Tóth et al.
Kristina Vlahovic et al.
Background/Objectives: To improve the potential therapeutic efficacy of albendazole (ABZ), its low solubility in alkaline environments should be addressed. Spray drying has been widely applied to increase the solubility of poorly soluble dr...
Design and Production of Respirable Effervescent Microparticles to Enhance Drug Penetration Through Lung Mucus [0.03%]
设计和制备呼吸性微粒泡腾颗粒以增强药物穿过肺黏液的能力
Valentina Ruggiero,Francesca Mariano,Domenico Larobina et al.
Valentina Ruggiero et al.
Background/Objectives: Dry powder inhalation (DPI) is a promising strategy for the treatment of respiratory diseases such as cystic fibrosis (CF), where thick and viscous mucus limits drug penetration and contributes to persistent infection...