ApiRegenin, an Animal-Derived Platelet-Rich Plasma Extract, Accelerates Wound Healing of Chronic Diabetic Ulcer in Mice [0.03%]
一种来源于动物的富含血小板血浆提取物ApiRegenin可加速糖尿病小鼠慢性创面愈合
Zheng-Qi Wang,Minnie Wing-Yi Mak,Xiong Gao et al.
Zheng-Qi Wang et al.
Background: Platelet-rich plasma (PRP) plays a crucial role in chronic wound healing by releasing growth factors that regulate inflammation, promote angiogenesis, and stimulate tissue regeneration. Methods and Results: Here, an animal sourc...
Xenon Encapsulation in Liposomes, Nanobubbles, and Microbubbles: Delivery Strategies, Preclinical Evidence, and Translational Barriers [0.03%]
氙气在脂质体、纳腔和微气泡中的包封：递送策略，临床前证据及转化障碍
Rostislav A Cherpakov,Vera S Shashkovskaya,Oleg A Grebenchikov et al.
Rostislav A Cherpakov et al.
Xenon is an active noble gas with anesthetic, neuroprotective and organ-protective properties, but its therapeutic application remains limited by high cost, the need for specialized delivery systems, and the inefficiency of conventional inh...
In Vitro and Ex Vivo Studies on the Absorption and Distribution of β-Cyclodextrin Polymer [0.03%]
关于β-环糊精聚合物吸收和分布的体内和体外研究
Réka Révész,Akay Dogan Mengenli,Ágnes Rusznyák et al.
Réka Révész et al.
Background: Cyclodextrin (CD) polymers have attracted increasing attention due to their favourable drug delivery properties and broad pharmaceutical applicability. While the bioavailability and biological behaviour of native cyclodextrins h...
Engineered Melittin Delivers a Drug-Loaded 'Chemo-Sting' to Overcome Efflux-Mediated Multidrug Resistance in Cancer Cells [0.03%]
工程蜂毒肽携载药物实现“化疗蜇刺”以克服癌细胞多药耐药性
Nurul Ain Mohammad Hamdi,Aya M Emam,Richard A Bryce et al.
Nurul Ain Mohammad Hamdi et al.
Background: Multidrug efflux proteins, frequently overexpressed in cancer cells, reduce intracellular drug accumulation and limit chemotherapeutic efficacy. Short drug-binding peptides containing the WXXW motif have been shown to non-covale...
ADC Conjugation Strategies: From Technological Evolution to a Practical Selection Framework [0.03%]
ADC偶联策略：从技术演变到实用选择框架
Sanggil Kim,Se-Ra Lee,Myung-Ho Sohn et al.
Sanggil Kim et al.
Antibody-drug conjugates (ADCs) have received renewed attention in oncology following the clinical and commercial success of agents such as trastuzumab deruxtecan (Enhertu®), which underscored the clinical importance of coordinated optimiz...
Advances in Dendrimer-Based Anti-Infective Systems: In Vivo Insights and Perspectives [0.03%]
基于树形分子的抗感染体系的研究进展：从体外到体内
Charlotte Aparici,Kevin Antraygues,Vania Bernardes-Génisson et al.
Charlotte Aparici et al.
The rise of antimicrobial resistance and the persistence of difficult-to-treat infections have stimulated interest in new strategies to overcome these problems. Among these strategies, dendrimers, which are highly branched monodisperse macr...
70 Years of DON and Beyond: Glutaminase Inhibition as a Synergistic Strategy in Cancer Combination Therapy [0.03%]
谷氨酰胺酶抑制在癌症联合治疗中的协同策略：DON的七十年及其展望
José A Campos-Sandoval,Juan De Los Santos-Jiménez,Javier Márquez et al.
José A Campos-Sandoval et al.
Personalized oncology seeks to selectively block specific dysregulated pathways to arrest cancer development. Increased glutamine metabolism is a hallmark of cancer, and 6-diazo-5-oxo-L-norleucine (DON), a structural analog of L-glutamine, ...
Peptide-Drug Conjugates for Targeted Delivery in Hematological Malignancies: From Design Principles to Clinical Application [0.03%]
靶向血液系统恶性肿瘤的肽-药物偶联物：从设计原则到临床应用
Ningdan Zhou,Mengyuan Li,Yanyan Huang et al.
Ningdan Zhou et al.
Hematological malignancies account for over 1.3 million new cases and approximately 700,000 deaths annually. Despite advances in targeted therapies, immunotherapies, and antibody-drug conjugates, relapse, refractory disease, and acquired dr...
Breaking the Silent Barrier: Engineering Antibodies for Brain-Targeted Rabies Immunotherapy [0.03%]
突破沉默屏障：工程抗体针对脑靶向狂犬病免疫疗法
Chen Sun,Liang Xiao,Xiao Guo et al.
Chen Sun et al.
Rabies remains one of the clearest therapeutic paradoxes in infectious diseases: it is largely preventable before neuroinvasion, yet once clinical symptoms appear, mortality approaches 100%. This sharp transition reflects more than delayed ...
Proteomic Stability and Ex Vivo Compatibility of a Processed Phospholipoproteic Secretome-Derived Formulation [0.03%]
一种加工后的磷脂蛋白衍生制剂的蛋白质组稳定性及体外兼容性
Ramón Gutiérrez-Sandoval,Francisco Gutiérrez-Castro,Natalia Muñoz-Godoy et al.
Ramón Gutiérrez-Sandoval et al.
Background: Processed extracellular lipid-protein preparations require rigorous analytical characterization to determine whether their compositional profile, processing stability, and short-term cellular compatibility are preserved across s...