Novel Camptothecin-Based Lipid Conjugated with Steroids and Triterpene Acids: Enhanced Cellular Uptake and Topoismerase I Inhibition [0.03%]
一种基于喜树碱的新型固醇和三萜酸修饰脂质体：提高细胞摄取和拓扑异构酶I抑制作用
Nuri M Chobanov,Konstantin O Vakhnin,Stepan E Logunov et al.
Nuri M Chobanov et al.
Background/Objectives: The clinical application of the potent antitumor alkaloid camptothecin is severely limited by its high systemic toxicity, poor solubility, and rapid inactivation. This study aimed to design, synthesize, and evaluate a...
Vibrating Mesh Nebulizer (A-VMN) Performance During Low-Flow Nasal Oxygen Therapy in Neonates [0.03%]
振动网式雾化器（A-VMN）在新生儿低流量鼻导管吸氧治疗中的性能评估
Rachel Burke,Mary Joyce,Elena Fernández Fernández et al.
Rachel Burke et al.
Background: Supplemental oxygen and aerosol therapy may be used simultaneously to treat neonates suffering from hypoxemia caused by respiratory diseases. Due to the cost and lack of availability of oxygen cylinders in some countries, oxygen...
Qingxin Mu
Qingxin Mu
Combination therapy has evolved rapidly over the past few decades into a powerful strategy to address complex health challenges such as cancer [...].
PEG-RLI: A Long-Acting IL-15 Agonist That Produces Massive Levels of CD8+ and CD44hiCD8+ Cells for Cancer Immunotherapy [0.03%]
PEG-RLI：一种长效的IL-15激动剂，可产生大量CD8+和CD44hiCD8+细胞用于癌症免疫治疗
Rocio Del Valle Fernandez,Guillermo Hails,John A Hangasky et al.
Rocio Del Valle Fernandez et al.
Background/Objectives: Interleukin-15 (IL-15) is a promising immunotherapeutic cytokine, but its short half-life limits clinical utility. We developed a stable PEGylated receptor-linker IL-15 agonist (PEG-RLI) to improve pharmacokinetic pro...
First-in-Human Dose Selection, Pharmacokinetics Prediction, and Clinical Validation of SYHA1805, a Novel FXR Agonist, Using Allometric Scaling and PBPK Modeling [0.03%]
基于全索引缩放及PBPK模型的全新FXR激动剂SYHA1805人体首次剂量探索、药代动力学预测及临床验证研究
Lei Zhang,Miao Zhang,Enda Zhou et al.
Lei Zhang et al.
Background: SYHA1805 is a potent farnesoid X receptor (FXR) agonist currently in development for Metabolic Dysfunction-Associated Steatohepatitis (MASH). Methods: To determine the first-in-human (FIH) dose and guide its clinical development...
Nanocarrier-Mediated Non-Invasive Drug Delivery for Wet Age-Related Macular Degeneration: Advances and Translational Challenges [0.03%]
用于治疗湿性年龄相关性黄斑变性的非侵入式药物递送的纳米载体：进展与转化挑战
Shasha Wang,Linfei Liu,Xiaoling Zeng et al.
Shasha Wang et al.
Wet age-related macular degeneration (wAMD) is characterized by choroidal neovascularization (CNV) and remains a major cause of severe vision loss in older adults. Intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is ...
Pharmacokinetics, Pharmacodynamics and Immunogenicity of AC02, a Novel Synthetic Derivate Peptide of Human Adrenocorticotropic Hormone for Infantile Spasms [0.03%]
人促肾上腺皮质激素类似物AC02治疗婴儿痉挛的药代动力学、药效学及免疫原性研究
Shunbo Zhao,Bingda Wu,Hui Shen et al.
Shunbo Zhao et al.
Objectives: AC02, a novel synthetic peptide derived from ACTH, is being developed as a potential therapeutic alternative to porcine ACTH1-39 for use in infantile spasms. Methods: The study comprised single-ascending dose cohorts (0.02, 0.04...
Improving the Stability of Transfersome Systems by Co-Encapsulating Components of Varying Hydrophobicity [0.03%]
通过共封装不同疏水性的成分改进转移体系统的稳定性
Xin Shen,Mian Zhao,Muhammad Hamza et al.
Xin Shen et al.
Background: As a novel drug delivery vehicle, transfersomes (TFSs) have great deformability, good biocompatibility, and biodegradability, which can significantly improve drug delivery efficiency. However, their application is limited by the...
Effect of Combined Polyphenol on the Disease Course in Children Diagnosed with Influenza [0.03%]
联合多酚对流感患儿病程的影响
Eren Güzeloğlu,Vefik Arica,Belen Ateş et al.
Eren Güzeloğlu et al.
Objective: This multicenter retrospective real-world data study aimed to evaluate whether the use of a preparation containing polyphenol, vitamin D3, vitamin C, and zinc in addition to antiviral therapy was associated with symptom duration ...
Matrix-Bound Nanovesicles as Tissue-Specific Signaling Hubs for Immunomodulation and Precision Regenerative Medicine [0.03%]
矩阵结合纳米囊泡作为免疫调节和精准再生医学的组织特异性信号中心
Peyton M Leyendecker,George S Hussey
Peyton M Leyendecker
The evolution of regenerative medicine has repositioned the extracellular matrix (ECM) from a passive structural scaffold to a dynamic signaling hub that dictates host immunity and tissue remodeling. A critical driver of this bioactivity is...