Mapping Scientific Landscapes and Therapeutic Innovations of Targeted Protein Degradation: A Scientometric Review [0.03%]
靶向蛋白质降解的科学景观和治疗创新的科学计量学综述
Chong Li,Xiangxiu Wang,Anqi He et al.
Chong Li et al.
Targeted Protein Degradation (TPD) has emerged as a transformative paradigm in drug discovery, offering a robust strategy to address "undruggable" targets. This study presents the first 25-year longitudinal scientometric analysis (2001-2025...
TPGS Analog-Mediated Intracellular ROS-Amplifying Strategy Potentiates the In Vitro Anticancer Activity of a Dual-Thioketal-Linked Polymeric Drug Conjugate in A549 Lung Cancer Cells [0.03%]
基于TPGS的类介导ROS放大策略增强双硫环修饰聚合物药物缀合物对A549肺癌细胞的体外抗癌活性
Hyun-Chul Kim,Kyeong-Min Lee,Yeo Jin Hwang et al.
Hyun-Chul Kim et al.
Background/Objectives: Reactive oxygen species (ROS)-responsive polymeric drug conjugates (PDCs) can enable oxidative stress-triggered drug release, but their activation may be limited by heterogeneous or insufficient intracellular ROS. Her...
Feasibility Study of Nose-to-Brain Delivery of Galantamine for Alzheimer's Disease: Enhancing Olfactory-Region Deposition to Improve Therapeutic Efficacy [0.03%]
用于阿尔茨海默病的石菖蒲鼻脑递送可行性研究：增强嗅区沉积以提高疗效
Chuangxin Chen,Chunying Leung,Zizhao Zhai et al.
Chuangxin Chen et al.
Background: Alzheimer's disease (AD) is the seventh leading cause of death worldwide, posing a substantial global health burden. Although galantamine (GNT) is a first-line clinical drug for AD treatment, its therapeutic efficacy is constrai...
Pharmacogenomics of Rivaroxaban: Association of CYP3A4, CYP3A5, CYP2J2, ABCB1, and ABCG2 Variants with Bleeding and Thrombotic Outcomes in Real-World Clinical Practice [0.03%]
利伐沙班的药物基因组学：CYP3A4、CYP3A5、CYP2J2、ABCB1 和 ABCG2 基因多态性与真实世界临床实践中的出血和血栓结局之间的关联
Ana Marija Slišković,Vladimir Trkulja,Lana Ganoci et al.
Ana Marija Slišković et al.
Aim: To evaluate associations between polymorphisms in CYP3A4 (*1B, *22), CYP3A5 (*3), CYP2J2 (*7, rs11572325), ABCB1 (c.1236C>T, c.2677G>T/A, c.3435C>T, rs4148738) and ABCG2 (c.421C>A) and the occurrence of bleeding or o...
Plant Extracts and Bee Products as Bioactive Compounds: From Mechanism to Delivery [0.03%]
植物提取物和蜂产品作为生物活性化合物：从机制到输送
Radosław Balwierz,Ewelina Szliszka,Małgorzata Kłósek et al.
Radosław Balwierz et al.
Plant extracts and bee products have accompanied pharmacotherapy for centuries and remain among the most productive sources of pharmacologically active substances, particularly in oncology and infectious diseases [...].
Modeling of Residence Time Distributions of Twin-Screw Extrusion Processes Considering Various Screw Types [0.03%]
考虑不同类型螺杆的双螺杆挤出过程停留时间分布的模拟
Vincent Kimmel,Dario Zöllig,Werner Hoheisel et al.
Vincent Kimmel et al.
Purpose: Residence time in pharmaceutical hot-melt extrusion is a crucial process parameter affecting the quality attributes of a dosage form such as content uniformity, bioavailability and toxicity. There is a lack of knowledge about the i...
Targeting CDK4/6 in Combination with Phage-Based Anti-HER2 Vaccination Overcomes Immune Evasion and Enhances the Anticancer Response in Breast Cancer [0.03%]
靶向CDK4/6与基于噬菌体的抗HER2疫苗联合治疗可克服免疫逃逸并增强乳腺癌的抗癌反应
Junbiao Wang,Alessia Lamolinara,Daniele Tomassoni et al.
Junbiao Wang et al.
Background/Objectives: Cancer vaccines represent the next frontier in immunotherapy, aiming to elicit long-lasting protective anti-tumor immune responses. Human epidermal growth factor receptor 2 (HER2) is a well-established therapeutic tar...
Advances in Functional Vascular Stents for Cardiovascular Therapy with Drug Delivery and Computational Design [0.03%]
具有药物输送和计算设计的功能血管支架在心血管治疗中的应用进展
Xiaotian Xu,Yan Hu,Haifang Li et al.
Xiaotian Xu et al.
Vascular stents are crucial devices in the treatment of cardiovascular diseases, and their structural design and function critically affect therapeutic efficacy and patient prognosis. Conventional stents can effectively restore vascular pat...
Beyond Carrier Design: Fabrication Method as the Hidden Driver of NSAID Nanomedicine Performance [0.03%]
超越载药设计：NSAIDs纳米药物性能的制造方法隐性驱动力
Ana-Maria Raluca Pauna,Liliana Mititelu-Tartau,Angy Abu Koush et al.
Ana-Maria Raluca Pauna et al.
Background/Objectives: Diclofenac (DCF) and other nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation management; however, their clinical significance is limited by poor aqueous solubility, short biologic...
Fusion Inhibition of Zika Virus Entry by a Teicoplanin Pseudoaglycone Derivative with Broad Antiviral Activity [0.03%]
广谱抗病毒的伪糖苷泰利霉素衍生物抑制寨卡病毒感染融合作用
Zoltán Kopasz,Ilona Bereczki,Krisztina Leiner et al.
Zoltán Kopasz et al.
Background/Objectives: The lack of effective antiviral therapies for many viral infections highlights the need for the development of new antiviral agents. The broad antiviral effects of glycopeptide antibiotics (GPAs) and their derivatives...