The Detrimental Effects of Crystalline Excipients: How They Jeopardize the Long-Term Stability of Freeze-Dried Polypeptide Formulations [0.03%]
结晶辅料的负面影响：它们如何危害冷冻干燥肽类制剂的长期稳定性
Han Gao,Jun Ouyang,Zhi-Bo Hu et al.
Han Gao et al.
Background: Despite the growing importance of polypeptide-based drugs in clinical therapy, studies investigating the stability of their freeze-dried formulations remain scarce. Crystalline excipients, such as mannitol, are commonly used in ...
Surfactants Significantly Improved the Oral Bioavailability of Curcumin Amorphous Solid Dispersions and Its Underlying Mechanism [0.03%]
表面活性剂显著改善了-curcumin无定形固体分散体的口服生物利用度及其潜在机制
Jinhua Yuan,Siyi Mao,Xiuzhen Ma et al.
Jinhua Yuan et al.
Background/Objectives: Surfactants are commonly used in amorphous solid dispersions (ASDs) to improve drug dissolution. A mechanistic understanding of their impact on in vitro dissolution and in vivo pharmacokinetics is essential for ration...
Generation of a Bioengineered Substitute of the Human Sclero-Corneal Limbus Using a Novel Decellularization Method [0.03%]
一种新型脱细胞方法生成人角膜缘生物工程技术替代品
Paula Ávila-Fernández,David Sánchez-Porras,Miguel Etayo-Escanilla et al.
Paula Ávila-Fernández et al.
Background: Severe dysfunction of the human limbus associated with limbal stem cell deficiency is a therapeutic challenge, especially when a structural alteration of the limbal niche is associated. Methods: We have evaluated seven decellula...
From Screening to a Nanotechnological Platform: Cannabidiol-Chemotherapy Co-Loaded Lipid Nanocapsules for Glioblastoma Multiforme Treatment [0.03%]
从筛选到纳米技术平台： cannabidiol-化学疗法共载脂质纳米囊泡用于治疗多形性胶质母细胞瘤
Laura Gómez-Lázaro,Juan Aparicio-Blanco,Ana Isabel Fraguas-Sánchez et al.
Laura Gómez-Lázaro et al.
Background/Objective: Cannabidiol (CBD) has gained increasing interest due to its multifaceted anticancer properties and favourable safety profile. Glioblastoma multiforme (GBM), a highly aggressive brain tumour with limited treatment optio...
Advances in Drug Delivery Science for Diacerein: Strategies to Enhance Solubility, Bioavailability, and Pharmacokinetic Performance [0.03%]
用于迪塞雷因的药物递送科学进展：增强溶解性、生物利用度和药代动力学性能的策略
Maryam Naseri,Sajjad Ghobakhlou,Niloofar Heidarizade et al.
Maryam Naseri et al.
Diacerein is known as a disease-modifying anti-inflammatory drug, primarily used for the treatment of osteoarthritis. Despite its therapeutic potential, the clinical use of diacerein is hindered by poor aqueous solubility, low bioavailabili...
Advances in β-Galactosidase Research: A Systematic Review from Molecular Mechanisms to Enzyme Delivery Systems [0.03%]
β-半乳糖苷酶研究进展：从分子机制到酶递送系统的一篇综述性文章
Márton Király,Ádám Tibor Barna,Nikolett Kállai-Szabó et al.
Márton Király et al.
Background/Objectives: β-galactosidase (lactase) is a transformative enzyme used in many different fields. Its significance spans from biotechnology to food and pharmaceutical industries. β-galactosidase catalyzes the hydrolysis of lactos...
Interpretable Artificial Neural Network Models for Predicting Anti-Adalimumab Immune Complex and Serum Drug Level in Crohn's Disease: A Proof-of-Concept Study [0.03%]
用于预测克罗恩病中抗阿达利姆单抗免疫复合物和血清药物浓度的可解释人工神经网络模型的概念验证研究
Livia Moreira Genaro,Juliana Carron,Gustavo Jacob Lourenço et al.
Livia Moreira Genaro et al.
Background: The development of anti-drug antibodies (ADAs) and resulting immune complexes are key mechanisms behind the secondary loss of response to adalimumab in Crohn's disease (CD). Despite their clinical importance, routine immunogenic...
Evaluation of Skin Penetration of Fluorescent Dissolved Formulations Using Confocal Laser Scanning Microscopy [0.03%]
利用共聚焦激光扫描显微镜评价荧光溶液化体系的经皮吸收能力
Yoshihiro Oaku,Toshinari Kuwae,Takeshi Misono et al.
Yoshihiro Oaku et al.
Background/Objectives: Transdermal formulations are widely utilized in the pharmaceutical and cosmetic fields because they enable non-invasive administration and sustained local drug delivery. Conventional ex vivo skin permeation experiment...
Development and Characterization of Magnoliae Flos Essential-Oil-Loaded Nanoemulsion: A Spatiotemporal Nose-to-Brain Delivery Enhancer for Solution and Gel-Based Pharmaceutical Formulations [0.03%]
一种用于溶液和凝胶基药剂配方的时空鼻脑输送增强技术：Magnoliae Flos精油纳米乳液的开发与表征
Shiyu Zong,Miao Wang,Xinyu Ma et al.
Shiyu Zong et al.
Objective: To develop a stable nanoemulsion loaded with Magnoliae Flos essential oil (MEO-NE) and evaluated its potential as an enhancer for nose-to-brain delivery in both solution and gel formulations. Methods: The MEO-NE was prepared usin...
Formulation and Analytical Evaluation of Liquid Cannabidiol Preparations: Comparative Study of Oil-Based Solutions and Emulsions [0.03%]
液体制备大麻二酚配方的制定和分析评估：油基溶液与乳状液的比较研究
Robert-Alexandru Vlad,Lénárd Farczádi,Denisa Paliștan et al.
Robert-Alexandru Vlad et al.
Background/Objectives: Cannabidiol (CBD) is a non-psychoactive compound found in the Cannabis sativa plant. Due to its broad therapeutic potential, CBD is often incorporated into various pharmaceutical formulations. This study aimed to eval...