NIR-Responsive Gold-Decorated Phase-Change Nanodroplets for Photothermal-Triggered Pulsatile Doxorubicin Release and Enhanced Combined Photothermal-Chemotherapy in Triple-Negative Breast Cancer [0.03%]
用于三阴性乳腺癌光热联合化疗的近红外响应金修饰相变纳米液滴介导多西他赛药物脉冲释放研究
Luyao Ma,Fulai Chen,Qinghao Xu et al.
Luyao Ma et al.
Background: Triple-negative breast cancer (TNBC), devoid of actionable targets for endocrine or HER2-directed therapy, is highly aggressive with elevated risks of recurrence and metastasis; surgical resection remains the mainstay of treatme...
Anti-PEG Immunogenicity of mRNA-LNP Vaccines in Humans: Evidence for Population-Level Changes in the Anti-PEG Antibody Repertoire [0.03%]
人类对基于脂质纳米颗粒的mRNA疫苗的抗聚乙二醇免疫原性：群体水平上抗聚乙二醇抗体库变化的证据
Réka Facskó,Tamás Mészáros,Petra Berényi et al.
Réka Facskó et al.
Background/Objectives: Polyethylene glycol (PEG) is widely used to enhance the stability and pharmacokinetics of nanomedicines, including lipid nanoparticle (LNP)-based mRNA vaccines. However, both pre-existing and vaccine-induced anti-PEG ...
Backbone-Minimised Nanoplasmid DNA Systems Enable High-Titre AAV Production in Suspension HEK293 Platforms [0.03%]
Backbone-最小化的纳米质粒DNA系统可在悬浮HEK293平台上实现高滴度AAV生产
Lewis Hall,Michael J Fiore,Joel Abramovich et al.
Lewis Hall et al.
Background: Scalability and cost remain major manufacturing barriers limiting broad patient access to adeno-associated virus (AAV) gene therapies. While capsid engineering has advanced vector biology, comparatively fewer innovations have ad...
Filipa Bettencourt,Patrícia C Pires,Francisco Veiga et al.
Filipa Bettencourt et al.
The development of oral drug delivery systems has become a major priority for pharmaceutical technology, driven by the growing demand for medicinal products that improve compliance, enhance therapeutic efficacy, and minimise drug-related ad...
Design and Characterization of GelMA Nanogels (nanoGelMA) via Desolvation and Photopolymerization for Drug Delivery Applications [0.03%]
通过脱溶和光聚合设计及表征用于药物递送的明胶甲基丙烯酸酯纳米凝胶（nanoGelMA）
Roberta Pappalardo,Rossella Laurano,Claudio Cassino et al.
Roberta Pappalardo et al.
Background/Objectives: Micro- and nano-scale hydrogels (microgels and nanogels) have attracted increasing attention as carriers for drug delivery due to their high-water content, responsiveness to external stimuli, tunable properties, and v...
An Evaluation of the Effects of the Ruthenium (II)-Uracil Schiff Base Complex on Selected Markers of Glucose Homeostasis in Diet-Induced Prediabetic Male Rats [0.03%]
评估含尿嘧啶希夫碱的活性分子对糖尿病前期大鼠血糖稳态影响的研究
Zenele Chonco,Nompumelelo Anna-Cletta Gumede,Andile Khathi et al.
Zenele Chonco et al.
Background: The onset of type 2 diabetes mellitus (T2DM) is often preceded by prediabetes, a reversible state of insulin resistance and impaired glucose regulation driven by the chronic consumption of a high-calorie diet and sedentary lifes...
Nanomedicine-Mediated Autophagy Modulation in Placental Impairment Versus Cancers: A Narrative Review [0.03%]
胎盘损伤与癌症中的纳米医学介导的自噬调控：综述文章
Melinda Ildiko Mitranovici,Viviana Ivan,Adrian Apostol et al.
Melinda Ildiko Mitranovici et al.
The biggest challenge faced by classical anticancer therapy is drug resistance, which causes cancer recurrence and metastasis. Two underlying mechanisms could be responsible, including the stemness of pro-survival autophagy-associated cance...
Naphthalene-Type Glycosides from Rumex obtusifolius Roots and Their Protective Effects Against Muscle Atrophy in C2C12 Myotubes [0.03%]
Rumex obtusifolius根中萘型苷的分离及其对C2C12肌管肌肉萎缩的保护作用
Yun Seok Joh,Jung Eun Park,Moon Jin Ra et al.
Yun Seok Joh et al.
Background/Objectives:Rumex obtusifolius L. (Polygonaceae) has been traditionally used to treat various disorders, including hepatic and gastrointestinal diseases. However, the phytochemical constituents of its roots and their potential pro...
Anti-Inflammatory Effects of Ginsenoside Rg1 and Low-Dose Ginseng Extract in an Astrocyte-Microglia Co-Culture Model of Inflammation [0.03%]
人参皂苷Rg1和低剂量人参提取物的抗炎作用：一种 astrocyte-microglia共培养模型的研究
Shaoning An,Laura Schönfelder,Peter Reusch et al.
Shaoning An et al.
Background: Neuroinflammation contributes to the etiopathology and symptom severity of neurodegenerative and neuropsychiatric disorders. Glial cells, especially microglia and astrocytes, play a crucial role in neuroinflammation. It has been...
Diagnosing the Information Limits of In Vitro Drug Release from PLGA Microparticle Data [0.03%]
基于PLGA微粒体外释放数据的诊断信息限制
Kushaan Sharma,Aryan Shah,Syna Sharma et al.
Kushaan Sharma et al.
Background/Objectives: Poly(lactic-co-glycolic acid) (PLGA) microparticles are widely used for sustained drug delivery, yet the release behavior reported in the literature remains difficult to predict across studies. It was hypothesized tha...