Synthesis and Evaluation of N-substituted Imidazole Derivatives for Antimicrobial Activity [0.03%]
用于抗菌活性的N取代咪唑衍生物的合成与评估
Namita Gupta,D P Pathak
Namita Gupta
A series of N-substituted imidazole derivatives was synthesized. Imidazole nucleus was reacted with ethylchloroacetate to form imidazole ester. Reaction of the imidazole ester (I) with different amines yields the desired products (1a- 1e). ...
Solubility prediction of satranidazole in propylene glycol-water mixtures using extended hildebrand solubility approach [0.03%]
采用扩展的Hildebrand溶度参数方法预测Satranidazole在丙二醇-水混合物中的溶解度
P B Rathi
P B Rathi
Extended Hildebrand solubility approach is used to estimate the solubility of satranidazole in binary solvent systems. The solubility of satranidazole in various propylene glycol-water mixtures was analyzed in terms of solute-solvent intera...
Estimation of Total Phenols and Flavonoids in Extracts of Actaea spicata Roots and Antioxidant Activity Studies [0.03%]
Actaea spicata根部提取物总酚和黄酮含量的测定及抗氧化活性研究
R Madaan,G Bansal,S Kumar et al.
R Madaan et al.
Actaea spicata Linn. (Ranunculaceae) has been traditionally used for the treatment of various ailments such as rheumatism, inflammation, nerve diseases, lumbago, scrofula and chorea, but no systematic phytochemical and pharmacological work ...
D Gude,D P Bansal
D Gude
Antitubercular therapy (ATT) induced hepatotoxicity, although well known to clinicians, is often over looked and underrated. Given the low threshold of starting ATT, especially empirically, the adverse manifestations can take a considerable...
Inhalational system for Etoposide liposomes: formulation development and in vitro deposition [0.03%]
用于依托泊苷脂质体的吸入系统：制剂开发及体外沉积研究
J J Parmar,D J Singh,A A Lohade et al.
J J Parmar et al.
Etoposide is a semisynthetic compound, widely used in treatment of non small cell lung cancer. However, frequent dosing and adverse effects remain a major concern in the use of etoposide. Liposomal systems for pulmonary drug delivery have b...
Determination and estimation of pharmacokinetic profile of caffeine in form of extract of green tea leaves and its analogy with synthetic form [0.03%]
绿茶叶提取物中咖啡因的药动学特征及与合成品的比较研究
Sangeetha Shanmugasundaram,N Manjunatha,R Vijayan et al.
Sangeetha Shanmugasundaram et al.
The aim of the study was to formulate and investigate the pharmacokinetic parameters for the tablets of herbal extract of caffeine with comparison to synthetic formulation. The tablets of the aqueous herbal extract of leaves of Camellia sin...
Development and evaluation of microbial degradation dependent compression coated secnidazole tablets for colonic delivery [0.03%]
一种用于结肠递送的压缩包衣片剂（含有塞克硝唑并依赖微生物降解）的研发与评估
B K Sridhar,A Srinatha,B B Zaman et al.
B K Sridhar et al.
The present paper describes development of a polysaccharide based compression coated tablets of secnidazole for colon delivery. Core tablet containing secnidazole was compression coated with various proportions of guar gum, xanthan gum and ...
Synthesis and evaluation of antiinflammatory, analgesic and ulcerogenic potential of NSAIDs bearing 1,3,4-oxadiazole scaffold [0.03%]
含1,3,4-噁二唑药效团的非甾体抗炎药物的设计合成及评价研究
R R Somani,U V Bhanushali
R R Somani
Synthesis of 1,3,4-oxadiazole derivatives of diclofenac and mefenamic acid are described. The target compounds 5-[2-(2,6-dichloroanilino)benzyl]-2-aryl-1,3,4-oxadiazole (3a-3e) and 5-[2-(2,3-dimethylanilino)phenyl]-2-(aryl)-1,3,4-oxadiazole...
Ranitidine Hydrochloride-loaded Ethyl Cellulose and Eudragit RS 100 Buoyant Microspheres: Effect of pH Modifiers [0.03%]
含法莫替丁氯化物的乙基纤维素和Eudragit RS 100缓释微球：pH值调节剂的影响
N R Kotagale,A P Parkhe,A B Jumde et al.
N R Kotagale et al.
A floating type of dosage form of ranitidine hydrochloride in the form of microspheres capable of floating on simulated gastric fluid was prepared by solvent evaporation technique. Microspheres prepared with ethyl cellulose, Eudragit(®) RS...
Effect of Fluoxetine on an Experimental Model of Diabetes-induced Neuropathic Pain Perception in the Rat [0.03%]
氟西汀对糖尿病诱发的神经病理性疼痛模型大鼠痛觉影响的研究
S V Tembhurne,D M Sakarkar
S V Tembhurne
The aim of the present study was to study the effect of chronic treatment (9 weeks) of fluoxetine (20 mg/kg p.o.) a selective serotonin reuptake inhibitor on blood glucose level and in prevention of diabetic neuropathic pain perception. Eva...