New evidence in the management of CMV infection: impact on prophylaxis and treatment [0.03%]
CMV感染的管理新证据：对预防和治疗的影响
Jesús Fortún
Jesús Fortún
Cytomegalovirus (CMV) infection is a leading cause of morbidity and mortality among immunocompromised individuals, especially hematopoietic stem cell transplant and solid organ transplant recipients. In recent years, significant advances ha...
Legends, dogmas, presumptions, and demystifications in antibiotic therapy [0.03%]
抗生素治疗中的传说、教条、臆想和去神秘化
Rosa Blanes Hernández,Santiago de Cossio Tejido,Francesc Puchades Gimeno et al.
Rosa Blanes Hernández et al.
Suboptimal antimicrobial use is a global challenge driven by entrenched misconceptions and dogmas. This article aims to critically evaluate and debunk several widespread myths in infectious disease management that lead to overdiagnosis and ...
Therapeutic approach in the critically ill patient with suspected multidrug resistance [0.03%]
多重耐药患者危重病人的治疗方案
María Cruz Soriano-Cuesta,Marina López-Olivencia,Francisco Javier Candel et al.
María Cruz Soriano-Cuesta et al.
The treatment of infections caused by multidrug-resistant microorganisms (MDROs) in critically ill patients remains a major clinical challenge due to the high mortality associated with therapeutic failure. Delays in administering effective ...
Emilio Maseda,Alejandro Suárez-de la Rica
Emilio Maseda
This document focuses on the different aspects to be considered in order to improve the management of nosocomial peritonitis, particularly the changes in the epidemiology of causative microorganisms and the increasing emergence of pathogens...
Therapeutic optimization against bacteria carrying metalloenzymes: the battle for class B [0.03%]
针对金属酶耐药菌的治疗优化：B类β-内酰胺酶之战
Manuel Pina-Sánchez,Marta Rua,Francisco Javier Candel et al.
Manuel Pina-Sánchez et al.
The spread of metallo-β-lactamases (MBL)-producing Gram-negative bacilli represents a global health challenge, associated with increased mortality rates. The prevalence of MBL-producing isolates, particularly of New Delhi metallo-β-lactam...
Montserrat Rodríguez-Aguirregabiria
Montserrat Rodríguez-Aguirregabiria
Nosocomial pneumonia is one of the most common nosocomial infections and is associated with significant clinical and economic burdens, such as long-term hospitalization, high medical costs, and increased morbidity and mortality. The increas...
Comprehensive approach to primary immunodeficiencies in adulthood: recognition and diagnosis [0.03%]
成人原发性免疫缺陷的综合诊治策略：识别与诊断
Laura Muñoz-Echeverria,Juan Gabriel Sánchez-Cano,Juan Emilio Losa-García
Laura Muñoz-Echeverria
Primary immunodeficiencies, now referred to as inborn errors of immunity (IEI), are increasingly recognized in adults, not only in the pediatric population. In adults, they may present with recurrent, severe, or unusual infections, but also...
Current diagnostic approach to fungal infection in the critically ill patient [0.03%]
重症患者真菌感染的当前诊断方法
Alfredo Maldonado-Barrueco,Inmaculada Quiles-Melero,Julio García-Rodríguez
Alfredo Maldonado-Barrueco
Invasive fungal infections are a major cause of morbidity and mortality in critically ill patients, with an increasing global incidence and species diversity, especially after the SARS-CoV-2 pandemic. Diagnosis relies on a combination of cl...
Syndromic platforms in the management of infection in the critically ill patient: test indication and diagnostic interpretation [0.03%]
重症感染患者的综合征平台管理：检测指征和诊断解读
Sara Sanz,Natalia Burillo,Juan Manuel García-Lechuz
Sara Sanz
The timely and appropriate administration of empirical antibiotic therapy is critical for patient survival. However, several studies suggest that approximately 20-30% of patients presenting with sepsis receive inadequate antibiotic treatmen...
Emilia Cercenado,Francisco Javier Candel
Emilia Cercenado
This non-exhaustive minireview describes the main characteristics of the new beta-lactamase inhibitors (enmetazobactam, avibactam, relebactam, durlobactam, zidebactam, nacubactam, vaborbactam, taniborbactam, and xeruborbactam), their spectr...