Passing the El Greco test [0.03%]
通过埃尔·格列柯测试
Przemyslaw Prusinkiewicz,Enrico Coen
Przemyslaw Prusinkiewicz
In recent years, the increasing use of modelling to capture biological complexity has revealed two complementary approaches. One is to build ever more comprehensive models in the hope that they will lead to useful predictions. The other app...
Measuring variability [0.03%]
测量变动性
Marcelo Magnasco
Marcelo Magnasco
GENE EXPRESSION IS A NOISY STOCHASTIC PROCESS, SINCE IT INVOLVES AT ITS CORE INTERACTIONS BETWEEN SINGLE MOLECULES: a polymerase and a binding site. However, many biological processes directly dependent upon gene expression are reliable. Pr...
Mechanical factors activate beta-catenin-dependent oncogene expression in APC mouse colon [0.03%]
机械因素活化APC基因敲除小鼠结肠中β-联环蛋白依赖的癌基因表达
Joanne Whitehead,Danijela Vignjevic,Claus Fütterer et al.
Joanne Whitehead et al.
beta-catenin acts as a critical regulator of gastrointestinal homeostasis through its control of the Wnt signaling pathway, and genetic or epigenetic lesions which activate Wnt signaling are the primary feature of colon cancer. beta-catenin...
Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location [0.03%]
通过引导受体聚集和空间位置来适应合成纳米图案环境的细胞粘附和反应
Elisabetta Ada Cavalcanti-Adam,Daniel Aydin,Vera Catherine Hirschfeld-Warneken et al.
Elisabetta Ada Cavalcanti-Adam et al.
During adhesion and spreading, cells form micrometer-sized structures comprising transmembrane and intracellular protein clusters, giving rise to the formation of what is known as focal adhesions. Over the past two decades these structures ...
Light sheet-based fluorescence microscopy: more dimensions, more photons, and less photodamage [0.03%]
基于光片的荧光显微镜：更多的维度、更多的光子和更少的光毒性
Emmanuel G Reynaud,Uros Krzic,Klaus Greger et al.
Emmanuel G Reynaud et al.
Light-sheet-based fluorescence microscopy (LSFM) is a fluorescence technique that combines optical sectioning, the key capability of confocal and two-photon fluorescence microscopes with multiple-view imaging, which is used in optical tomog...
Nanoscale hydrodynamics in the cell: balancing motorized transport with diffusion [0.03%]
细胞中的纳米流体动力学：平衡马达驱动的运输和扩散
Robert H Austin
Robert H Austin
One of the central problems in the cell is how to transport molecules around the cell to desired locations. Since low Reynolds number conditions apply and diffusional times are large, without the aid of molecular motors to transport the flu...
Similia similibus: pairing of homologous chromosomes driven by the physicochemical properties of DNA [0.03%]
相似相吸：DNA的物理化学性质决定同源染色体配对
Arturo Falaschi
Arturo Falaschi
Genetic recombination in eukaryotes requires the pairing of homologous chromosomes to allow precise molecular exchanges between chromosome pairs at intertwined structures called Holliday junctions, the formation of which requires the action...
Saurabh Paliwal,C Joanne Wang,Andre Levchenko
Saurabh Paliwal
Signal transduction pathways are complex coupled sets of biochemical reactions evolved to transmit and process information about the state of the immediate cell environment. Can we design experiments that would inform us about the propertie...
Juergen Kast
Juergen Kast
Proteins are the true workhorses of any cell. To carry out specific tasks, they frequently bind other molecules in their surroundings. Due to their structural complexity and flexibility, the most diverse array of interactions is seen with o...
Toward integration of in vivo molecular computing devices: successes and challenges [0.03%]
体内分子计算设备的整合：成功与挑战
Sikander Hayat,Thomas Hinze
Sikander Hayat
The computing power unleashed by biomolecule based massively parallel computational units has been the focus of many interdisciplinary studies that couple state of the art ideas from mathematical logic, theoretical computer science, bioengi...