Quantitative differences in tissue surface tension influence zebrafish germ layer positioning [0.03%]
组织表面张力的定量差异影响斑马鱼胚层定位
Eva-Maria Schötz,Rebecca D Burdine,Frank Jülicher et al.
Eva-Maria Schötz et al.
This study provides direct functional evidence that differential adhesion, measurable as quantitative differences in tissue surface tension, influences spatial positioning between zebrafish germ layer tissues. We show that embryonic ectoder...
Role of bacterial peptidase F inferred by statistical analysis and further experimental validation [0.03%]
统计分析推测并进一步实验验证细菌肽酶F的作用
Liliana Lopez Kleine,Véronique Monnet,Christine Pechoux et al.
Liliana Lopez Kleine et al.
Despite the quantity of high-throughput data available nowadays, the precise role of many proteins has not been elucidated. Available methods for classifying proteins and reconstructing metabolic networks are efficient for finding global ca...
Compositionality, stochasticity, and cooperativity in dynamic models of gene regulation [0.03%]
基因调控动态模型中的组合性、随机性和协同性
Ralf Blossey,Luca Cardelli,Andrew Phillips
Ralf Blossey
We present an approach for constructing dynamic models for the simulation of gene regulatory networks from simple computational elements. Each element is called a "gene gate" and defines an inputoutput relationship corresponding to the bind...
Ashesh Dhawale,Upinder S Bhalla
Ashesh Dhawale
A century ago, Ramón y Cajal proposed that the brain consisted of huge numbers of neurons that communicated with each other through junctions called synapses. Today we routinely monitor single neuron and single synapse responses, and we ha...
Fred S Wouters,Alessandro Esposito
Fred S Wouters
Fluorescence lifetime imaging is a valuable and versatile tool for the investigation of the molecular environment of fluorophores in living cells. It is ideally suited-and is therefore increasingly used-for the quantification of the occurre...
Insight or illusion? Seeing inside the cell with mesoscopic simulations [0.03%]
洞察还是错觉？用介观模拟观察细胞内部结构
Julian C Shillcock
Julian C Shillcock
The expulsion of material from a cell by fusion of vesicles at the plasma membrane, and the entry of a virus by membrane invagination are complex membrane-associated processes whose control is crucial to cell survival. Our ability to visual...
Ingmar H Riedel-Kruse,Andreas Hilfinger,Jonathon Howard et al.
Ingmar H Riedel-Kruse et al.
Cilia and eukaryotic flagella are slender cellular appendages whose regular beating propels cells and microorganisms through aqueous media. The beat is an oscillating pattern of propagating bends generated by dynein motor proteins. A key op...
Direct mechanical measurement of geodesic structures in rat mesenchymal stem cells [0.03%]
大鼠间充质干细胞中介导结构的直接力学测量法
P Maguire,J I Kilpatrick,G Kelly et al.
P Maguire et al.
During numerous biological processes, cell adhesion, cell migration and cell spreading are vital. These basic biological functions are regulated by the interaction of cells with their extracellular environment. To examine the morphology and...
Trends in fluorescence imaging and related techniques to unravel biological information [0.03%]
用于解密生物信息的荧光成像及相关技术研究进展
Elke Haustein,Petra Schwille
Elke Haustein
Optical microscopy is among the most powerful tools that the physical sciences have ever provided biology. It is indispensable for basic lab work, as well as for cutting edge research, as the visual monitoring of life processes still belong...
Patrick Forterre,Simonetta Gribaldo
Patrick Forterre
The study of the origin of life covers many areas of expertise and requires the input of various scientific communities. In recent years, this research field has often been viewed as part of a broader agenda under the name of "exobiology" o...