A structural model of latent evolutionary potentials underlying neutral networks in proteins [0.03%]
蛋白质中中性网络潜在进化势的结构模型
Richard Wroe,Hue Sun Chan,Erich Bornberg-Bauer
Richard Wroe
A central question in molecular evolution concerns the nature of phenotypic transitions, in particular, if neutral mutations hamper or somehow facilitate adaptability of proteins to new requirements. Proteins have been found to fluctuate be...
Latent evolutionary potentials under the neutral mutational drift of an enzyme [0.03%]
中性突变漂变下酶的潜在进化天賦
Gil Amitai,Rinkoo Devi Gupta,Dan S Tawfik
Gil Amitai
Biological systems exhibit mutational robustness, or neutrality, whereby the impact of mutations is minimized. Does neutrality hamper their ability to adapt in the face of changing environments? We monitored changes in genotype and phenotyp...
A propagating ERKII switch forms zones of elevated dendritic activation correlated with plasticity [0.03%]
一种传播的ERKII开关形成与可塑性相关的树突激活升高区域
Sriram M Ajay,Upinder S Bhalla
Sriram M Ajay
Strong inputs to neurons trigger complex biochemical events leading to synaptic plasticity. These biochemical events occur at many spatial scales, ranging from submicron dendritic spines to signals that propagate hundreds of microns from de...
Magnetoreception in birds: different physical processes for two types of directional responses [0.03%]
鸟类磁感应的两种不同类型定向行为的物理过程不同
Roswitha Wiltschko,Katrin Stapput,Thorsten Ritz et al.
Roswitha Wiltschko et al.
Migratory orientation in birds involves an inclination compass based on radical-pair processes. Under certain light regimes, however, "fixed-direction" responses are observed that do not undergo the seasonal change between spring and autumn...
Kenji Doya
Kenji Doya
Reinforcement learning is a computational framework for an active agent to learn behaviors on the basis of a scalar reward signal. The agent can be an animal, a human, or an artificial system such as a robot or a computer program. The rewar...
Yoshiharu Ishii,Toshio Yanagida
Yoshiharu Ishii
Biomolecules dynamically work in cells in which a variety of molecules assemble and interact in unique manner. The molecular mechanisms underlying several biological processes have been elucidated from the results obtained from the descript...
Jonathon Howard,Iva M Tolić-Nørrelykke
Jonathon Howard
Microtubules and other proteins self-organize into complex dynamic structures such as the mitotic spindle, which separates the chromosomes during cell division. Much is known about the individual molecular players involved in assembly and p...
Paul De Koninck,Simon Labrecque,Colin D Heyes et al.
Paul De Koninck et al.
Synapses are the principal substrates of neuronal communication in the brain. Neuroscientists are trying to understand how the remodeling of synapses at the molecular level leads to changes in learning and memory. The lateral movement of ne...
Mark Bisby
Mark Bisby
Arturo Falaschi
Arturo Falaschi