Energy landscape along an enzymatic reaction trajectory: hinges or cracks? [0.03%]
沿酶促反应轨迹的能量景观：铰链或裂隙？
Paul Charles Whitford,José Nelson Onuchic,Peter Guy Wolynes
Paul Charles Whitford
Are the most dynamically flexible regions around the equilibrium structure of an enzyme the same regions involved in the transition state for rate limiting processes involved in the enzymatic reaction? Kern and-coworkers (Wolf-Watzet al., 2...
Nigel G J Richards
Nigel G J Richards
Post-translational modification, such as phosphorylation or glycosylation, provides a mechanism for increasing the diversity of protein structures in the cell and regulating biological activity. In addition, such modifications may result in...
R Blossey,H Schiessel
R Blossey
Gene activation in eukaryotes involves the concerted action of histone tail modifiers, chromatin remodelers, and transcription factors, whose precise coordination is currently unknown. We demonstrate that the experimentally observed interac...
Guy Rachmuth,Chi-Sang Poon
Guy Rachmuth
Neuromorphic analog metal-oxide-silicon (MOS) transistor circuits promise compact, low-power, and high-speed emulations of iono-neuronal dynamics orders-of-magnitude faster than digital simulation. However, their inherently limited input vo...
Fast fluorescence microscopy for imaging the dynamics of embryonic development [0.03%]
快速荧光显微镜在胚胎发育动力学成像中的应用
Julien Vermot,Scott E Fraser,Michael Liebling
Julien Vermot
Live imaging has gained a pivotal role in developmental biology since it increasingly allows real-time observation of cell behavior in intact organisms. Microscopes that can capture the dynamics of ever-faster biological events, fluorescent...
Brain controlled robots [0.03%]
意念控制的机器人技术
Mitsuo Kawato
Mitsuo Kawato
In January 2008, Duke University and the Japan Science and Technology Agency (JST) publicized their successful control of a brain-machine interface for a humanoid robot by a monkey brain across the Pacific Ocean. The activities of a few hun...
Henry Markram
Henry Markram
The quest to understand the way in which neurons interconnect to form circuits that function as a unit began when Ramon y Cajal concluded that axo-dendritic apposition were too conspicuous to be incidental and proposed that two neurons must...
Igor I Smolyaninov
Igor I Smolyaninov
Over the past century the resolution of far-field optical microscopes, which rely on propagating optical modes, was widely believed to be limited because of diffraction to a value on the order of a half-wavelength lambda2 of the light used....
David K Karig,Michael L Simpson
David K Karig
Recent years have seen the emergence of synthetic biology, which encompasses the engineering of living organisms as well as the implementation of biological behavior in non-living substrates. Many of these engineered systems have harnessed ...
Arturo Falaschi
Arturo Falaschi