Solvation dynamics of biomolecules: modeling and terahertz experiments [0.03%]
生物分子溶剂化的动力学：建模与太赫兹实验研究
David M Leitner,Martin Gruebele,Martina Havenith
David M Leitner
The role of water in biomolecule dynamics has attracted much interest over the past decade, due in part to new probes of biomolecule-water interactions and developments in molecular simulations. Terahertz (THz) spectroscopy, among the most ...
Steven A Waldauer,Olgica Bakajin,Terry Ball et al.
Steven A Waldauer et al.
By exploring the folding pathways of the B1 domain of protein L with a series of equilibrium and rapid kinetic experiments, we have found its unfolded state to be more complex than suggested by two-state folding models. Using an ultrarapid ...
Victor Muñoz,Mourad Sadqi,Athi N Naganathan et al.
Victor Muñoz et al.
Traditionally, folding experiments have been directed at determining equilibrium and relaxation rate constants of proteins that fold with two-state-like kinetics. More recently, the combination of free energy surface approaches inspired by ...
Amit Mor,Gilad Haran,Yaakov Levy
Amit Mor
The unfolded state ensemble of proteins has been described as a structurally featureless state. While this approach is supported by the fact that many unfolded proteins follow the scaling law behavior of a random coil, there is evidence tha...
Sarah Batey,Adrian A Nickson,Jane Clarke
Sarah Batey
There have been relatively few detailed comprehensive studies of the folding of protein domains (or modules) in the context of their natural covalently linked neighbors. This is despite the fact that a significant proportion of the proteome...
Sandra Bensmihen,Andrew I Hanna,Nicolas B Langlade et al.
Sandra Bensmihen et al.
A key approach to understanding how genes control growth and form is to analyze mutants in which shape and size have been perturbed. Although many mutants of this kind have been described in plants and animals, a general quantitative framew...
Ralf Jungmann,Stephan Renner,Friedrich C Simmel
Ralf Jungmann
Attempts to construct artificial systems from biological molecules such as DNA and RNA by self-assembly are compatible with the recent development of synthetic biology. Genetic mechanisms can be used to produce or control artificial structu...
Coupling between neuronal activity and microcirculation: implications for functional brain imaging [0.03%]
脑活动与局部微循环之间的相互作用及对脑功能影像的影响
Ivo Vanzetta,Amiram Grinvald
Ivo Vanzetta
In the neocortex, neurons with similar response properties are often clustered together in column-like structures, giving rise to what has become known as functional architecture-the mapping of various stimulus feature dimensions onto the c...
"Developmental mechanics": cellular patterns controlled by adhesion, cortical tension and cell division [0.03%]
发育生物学中的细胞图案由粘附、皮层张力和细胞分裂控制
Thomas Lecuit
Thomas Lecuit
How embryos are shaped during development has inspired the work of many, embryologists, geneticists, but also mathematicians such as Turing, and physicists. Despite the inherent complexity of the problems it tackles, developmental biology h...
Manuel Théry,Michel Bornens
Manuel Théry
Cell rounding is a common feature of cell division. The spherical shape that cells adopt during mitosis is apparently neither a simple detachment nor a global softening or stiffening that allows cells to adopt what seems to be a mechanical ...