Luis G Morelli,Saúl Ares,Leah Herrgen et al.
Luis G Morelli et al.
Rhythmic and sequential subdivision of the elongating vertebrate embryonic body axis into morphological somites is controlled by an oscillating multicellular genetic network termed the segmentation clock. This clock operates in the presomit...
Balázs Papp,Bas Teusink,Richard A Notebaart
Balázs Papp
There has been considerable recent interest in deciphering the adaptive properties underlying the structure and function of metabolic networks. Various features of metabolic networks such as the global topology, distribution of fluxes, and ...
Classifying proteinlike sequences in arbitrary lattice protein models using LatPack [0.03%]
利用LatPack对任意晶格模型中的蛋白质样序列进行分类
Martin Mann,Daniel Maticzka,Rhodri Saunders et al.
Martin Mann et al.
Knowledge of a protein's three-dimensional native structure is vital in determining its chemical properties and functionality. However, experimental methods to determine structure are very costly and time-consuming. Computational approaches...
Problems in fitting high resolution structures into electron microscopic reconstructions [0.03%]
三维结构 fitted 进电子显微图像密度图的若干问题探讨
Edward H Egelman
Edward H Egelman
Great advances have been made in electron microscopy (EM) over the past decade, with the result that a number of protein complexes have been solved at near-atomic resolution using EM imaging. However, only a limited number of such complexes...
Joseph A Hegler,Patrick Weinkam,Peter G Wolynes
Joseph A Hegler
The universe of conformational substates of a protein molecule is huge. The complete energy landscape of proteins is, therefore, complex when studied at low temperature. Many experiments under physiological conditions commonly reveal a simp...
The extremely slow-exchanging core and acid-denatured state of green fluorescent protein [0.03%]
绿色荧光蛋白的慢交换核心及其酸变性状态
Jie-Rong Huang,Shang-Te Danny Hsu,John Christodoulou et al.
Jie-Rong Huang et al.
Green fluorescent protein (GFP) is a large protein with a complex eleven-stranded beta-barrel structure. Previous studies have shown that it has a complex energy landscape for folding on which there are several intermediate states and a den...
SOD1-associated ALS: a promising system for elucidating the origin of protein-misfolding disease [0.03%]
与SOD1相关的ALS：揭示蛋白质错误折叠疾病起源的一个有前景的系统
Anna Nordlund,Mikael Oliveberg
Anna Nordlund
Amyotropic lateral sclerosis (ALS) is a neurodegenerative disease linked to misfolding and aggregation of the homodimeric enzyme superoxide dismutase (SOD1). In contrast to the precursors of other neurodegenerative diseases, SOD1 is a solub...
Jeppe Falsig,K Peterr Nilsson,Tuomas P J Knowles et al.
Jeppe Falsig et al.
Transmissible spongiform encephalopathies (TSEs) are lethal infectious neurodegenerative diseases. TSEs are caused by prions, infectious agents lacking informational nucleic acids, and possibly identical with higher-order aggregates of the ...
Synchrotron radiation: micrometer-sized x-ray beams as fine tools for macromolecular crystallography [0.03%]
同步辐射：用于宏观分子晶体学的微米X射线光束工具
Thomas R Schneider
Thomas R Schneider
Structural data play a central role in understanding biological function at the molecular level. At present, the majority of high-resolution structural data about biological macromolecules and their complexes originates from crystallography...
Pál Ormos
Pál Ormos
The dynamic nature of protein function is a fundamental concept in the physics of proteins. Although the basic general ideas are well accepted most experimental evidence has an indirect nature. The detailed characterization of the dynamics ...