John X J Zhang
John X J Zhang
At the basis of neuroscience is the correlation between behavior and neural signals. This relationship is studied using a variety of techniques, including fluorescent intensity measurements of genetically encoded calcium indicators. The sim...
Arturo Falaschi,Gulnara Abdurashidova
Arturo Falaschi
Magnetic and optical tweezers are providing novel insights on the structure, energetics, and functional dynamics of biological macromolecules. The modulation of DNA topology has provided very appropriate opportunities to study with these te...
Building a realistic neuronal model that simulates multi-joint arm and hand movements in 3D space [0.03%]
构建一个现实的神经元模型以模拟三维空间中的多关节手臂和手的动作
Bror Alstermark,Ning Lan,Lars-Gunnar Pettersson
Bror Alstermark
The question as to how the brain controls voluntary movements of the arm and hand still remains largely unsolved despite much research focused on behavioral studies, neurophysiological investigations, and neuronal modeling in computer scien...
Characterization of the nucleation barriers for protein aggregation and amyloid formation [0.03%]
蛋白质聚集和淀粉样纤维形成的核化势垒的表征
Stefan Auer,Christopher M Dobson,Michele Vendruscolo
Stefan Auer
Despite the complexity and the specificity of the amino acid code, a variety of peptides and proteins unrelated in sequence and function exhibit a common behavior and assemble into highly organized amyloid fibrils. The formation of such agg...
Characterizing multiple metal ion binding sites within a ribozyme by cadmium-induced EPR silencing [0.03%]
利用镉诱导EPR淬灭法表征核酶中的多个金属离子结合位点
Natalia Kisseleva,Stefanie Kraut,Andres Jäschke et al.
Natalia Kisseleva et al.
In ribozyme catalysis, metal ions are generally known to make structural andor mechanistic contributions. The catalytic activity of a previously described Diels-Alderase ribozyme was found to depend on the concentration of divalent metal io...
Stefan Schaal
Stefan Schaal
Research in robotics has moved away from its primary focus on industrial applications. The New Robotics is a vision that has been developed in past years by our own university and many other national and international research institutions ...
Stefan Florian,Stefan Hümmer,Mario Catarinella et al.
Stefan Florian et al.
To understand biological processes, biologists typically study how perturbations of protein functions affect the phenotype. Protein activity in living cells can be influenced in many different ways: by manipulation of the genomic informatio...
E R Alvarez-Buylla,M Benítez,C Espinosa-Soto
E R Alvarez-Buylla
The paper, "Evolution and development of inflorescence architectures" by Przemyslaw Prusinkiewicz, Yvette Erasmus, Brendan Lane, Lawrence D. Harder and Enrico Coen [Science, 316, 1452-1456 (2007)], sets to accomplish a longstanding goal: to...
The subtle benefits of being promiscuous: adaptive evolution potentiated by enzyme promiscuity [0.03%]
酶低聚状态的微妙益处：适应性进化受益于酶的低聚状态
Mark A Depristo
Mark A Depristo
In this commentary we discuss recent progress in our understanding of adaptive protein evolution. We begin with a general introduction to proteins and their evolution, quickly focusing on the question of how natural selection produces prote...
Valerie Horsley,Elaine Fuchs
Valerie Horsley
Embryonic stem (ES) cells have the capacity to form every type of cell in our adult bodies due to their pluripotency. The prospective use of ES cells in regenerative therapies for human diseases such as Parkinson's disease and diabetes has ...