Pedro Correia,Elizabeth Hartl,Soheyl Noachtar
Pedro Correia
Self-stimulation is a normal part of development and a common behaviour in children before puberty, but very rare in adults. The stereotyped semiology can sometimes raise the suspicion of epilepsy. We present a 30-year-old patient who came ...
Multimodal assessment of language and memory reorganization: a proof of concept in two patients with drug-resistant temporal lobe epilepsy [0.03%]
语言和记忆重组的多模态评估：两种药物难治性颞叶癫痫患者的概念验证
Elise Roger,Cédric Pichat,Félix Renard et al.
Elise Roger et al.
We report two patients suffering from drug-resistant temporal lobe epilepsy to show how their neuroplasticity can be apprehended using a multimodal, integrative and clinically relevant approach. This is a proof of concept based on using mul...
Perampanel-induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome [0.03%]
与Pitt-Hopkins综合征相关的一位癫痫患者的Perampanel致卷发症病例报告
Yamile Calle-Lopez,Prakash Kotagal,Elia Pestana Knight
Yamile Calle-Lopez
Antiepileptic drug side effects are frequent, 42% of them corresponding to cosmetic changes. The most frequent effects are weight gain, gingival hyperplasia, and hair loss. Hair changes in texture or colour are rarely reported in the litera...
Epileptic encephalopathy with microcephaly in a patient with asparagine synthetase deficiency: a video-EEG report [0.03%]
天冬氨酰胺合成酶缺乏所致小头相关性癫痫性脑病一例报告
Paola Costa,Caterina Zanus,Flavio Faletra et al.
Paola Costa et al.
Asparagine synthetase deficiency is a rare autosomal recessive neurometabolic disorder caused by mutations in the asparagine synthetase gene. It is characterized by congenital microcephaly, intellectual disability, progressive cerebral atro...
Intermittent photic stimulation-provoked seizure associated with ictal asystole [0.03%]
间歇性光刺激诱发的伴发心动过缓的癫痫发作
Xiaoli Wang,Yonghong Liu
Xiaoli Wang
Ketogenic parenteral nutrition in three paediatric patients with epilepsy with migrating focal seizures [0.03%]
儿童游走性局灶性癫痫的酮体静脉注射疗法
Marisa Armeno,Antonella Verini,Maria B Araujo et al.
Marisa Armeno et al.
Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare epilepsy syndrome, characterized by an onset of multifocal seizures before the age of six months and a rather typical ictal EEG pattern. The ketogenic diet (KD) has been sh...
Widespread frontal lobe cortical dysplasia or partial hemimegalencephaly: a continuum of the spectrum [0.03%]
广泛额叶皮质发育不良或半侧巨脑症：连续谱的两端
Emilija Cvetkovska,Igor Kuzmanovski,Bojan Boskovski et al.
Emilija Cvetkovska et al.
Focal cortical dysplasia (FCD) type II and hemimegalencephaly (HME) are currently considered as a continuum of pathology, the most important distinction being the extent or the size/volume of the lesion. While partial HME involving the post...
Deep brain stimulation of the anterior nucleus of the thalamus in a patient with super-refractory convulsive status epilepticus [0.03%]
丘脑前核深部电刺激治疗超级顽固性癫痫持续状态一例报告
Liu Yuan,Shaohui Zhang,Shuangshuang Liang et al.
Liu Yuan et al.
We report the first patient to die from refractory convulsive status epilepticus (SE) after the removal of a stimulator. The removal occurred after a two-year period of successful control of super-refractory convulsive SE with deep brain st...
Genetic literacy series: clinical application of pharmacogenetics for adverse reactions to antiepileptic drugs [0.03%]
遗传 Literacy 系列：抗癫痫药物不良反应的药物基因组学临床应用
Zhongbin Zhang,Ye Wu,Nigel Ck Tan et al.
Zhongbin Zhang et al.
Adverse drug reactions are a leading cause of treatment failure with antiepileptic drugs. Adverse drug reactions are also a major source of morbidity and mortality, and a substantial burden on the use and costs of health care. Recent pharma...
Antiepileptic drugs: evolution of our knowledge and changes in drug trials [0.03%]
抗癫痫药物：知识的演变和药物试验的变化
Emilio Perucca
Emilio Perucca
Clinical trials provide the evidence needed for rational use of medicines. The evolution of drug trials follows largely the evolution of regulatory requirements. This article summarizes methodological changes in antiepileptic drug trials an...