Drug repositioning: Identification of potent inhibitors of NS3 protease and NS5 RdRp for control of DENV infection [0.03%]
药物再定位：鉴定登革病毒NS3蛋白酶和NS5 RNA依赖性RNA聚合酶强效抑制剂以控制DENV感染
Md Haroon Or Rashid,Sayeh Ezzikouri,Ahmed M Soliman et al.
Md Haroon Or Rashid et al.
Dengue virus (DENV) threatens global health; specific antiviral drugs are required to combat it. Such anti-DENV therapeutics can be rapidly developed by repositioning the drugs approved for other indications. This study investigated six med...
Lipidomics reveals different therapeutic potential for natural and synthetic vitamin D formulations in hepatocyte lipotoxicity [0.03%]
脂质组学揭示了天然和合成维生素D配方在肝细胞脂毒性中的不同治疗潜力
Anna Migni,Desirée Bartolini,Ina Varfaj et al.
Anna Migni et al.
Natural sources of vitamin D (VD), have been proposed to represent an alternative to synthetic vitamin D in nutritional interventions, also holding therapeutic potential in non-alcoholic fatty liver disease (NAFLD). In this study lipidomics...
Immunotherapy using allogenic NK cells downregulates mitochondrial-related genes and inhibits the OXPHOS system of malignant meningioma [0.03%]
同种异体NK细胞免疫治疗下调恶性脑膜瘤线粒体相关基因并抑制其OXPHOS系统
Ryosuke Maeoka,Ryosuke Matsuda,Tsutomu Nakazawa et al.
Ryosuke Maeoka et al.
Background: Malignant meningiomas (MM) are highly aggressive tumors and difficult to treat. Immunotherapy might be a promising treatment for cancers, including MM. This study assessed the anti-tumor effects of highly-puri...
Illuminating the dark: PEGylated carboxylated graphene quantum dots and curcumin in nucleolar activity and PDT-induced DNA damage in cancer [0.03%]
PEG化羧基石墨烯量子点和姜黄素在核仁活性及癌症 PDT 诱导的 DNA 损伤中的作用研究
Hanna Dilenko,Kateřina Bartoň Tománková,Elizabeth Hinde et al.
Hanna Dilenko et al.
Many photosensitive substances suitable for photodynamic therapy (PDT) have limited applications due to their insufficient solubility in polar solvents. Our research overcomes this challenge by means of nanotechnology in order to transform ...
Contemporary insights into elamipretide's mitochondrial mechanism of action and therapeutic effects [0.03%]
关于艾拉明肽的线粒体作用机制及其治疗作用的新认识
Hani N Sabbah,Nathan N Alder,Genevieve C Sparagna et al.
Hani N Sabbah et al.
Mitochondria are cellular hubs integral for metabolism, signaling, and survival. Mitochondrial dysfunction is centrally involved in the aging process and an expansive array of disease states. Elamipretide is a novel mitochondria-targeting p...
Nitric oxide synthases: A delicate dance between bone regeneration and neuronal birth [0.03%]
一氧化氮合酶：骨再生与神经元生成之间的微妙平衡
Niloofar Alahdad,Shayesteh Kokabi Hamidpour,Mohammad Ali Yazdanpanah et al.
Niloofar Alahdad et al.
Spinal cord injury (SCI) is a devastating condition resulting from traumatic or nontraumatic injury/chronic disorder. The pathogenesis of SCI necessitates a comprehensive approach, as it involves therapeutic strategies addressing both bone ...
Exacerbated cardiac dysfunction from combined alcohol binge and synthetic cannabinoid use [0.03%]
联合酒精暴饮和合成大麻素使用加重心脏功能障碍
Janos Paloczi,Ozge Gunduz-Cinar,Burhan Yokus et al.
Janos Paloczi et al.
Alcohol remains the most frequently used intoxicant, posing a significant global health concern. Binge drinking has been linked to acute cardiovascular complications, including reduced cardiac performance, arrhythmias, and blood pressure in...
Copper-quercetin complexes: methods of study, relevance to cell death pathways, therapeutic applications [0.03%]
铜-芦丁复合物：研究方法、与细胞死亡途径的相关性及治疗应用
Michael Kenneth Lawson
Michael Kenneth Lawson
Copper-quercetin complexes, CuQ, have been an active area of research for several decades. In vitro experiments show complexes are better antioxidants than quercetin alone. There seems to be a synergy effect. Cancer cell culture experiments...
Ru(II)-thymine complex suppresses acute myeloid leukemia stem cells by inhibiting NF-κB signaling [0.03%]
RU(II)-胸腺嘧啶复合物通过抑制NF-κB信号抑制急性髓系白血病干细胞
Maiara de S Oliveira,Ingrid R S B Dias,Rafaela G A Costa et al.
Maiara de S Oliveira et al.
Acute myeloid leukemia (AML) is a lethal hematologic malignancy caused by leukemic blasts that fail to mature normally. AML has a high relapse rate, primarily due to a small subset known as leukemic stem cells (LSCs). In this work, we inves...
Au@Fe₃O₄@PEG nanocubes as photoactive agents in photothermal therapy: An in vitro study [0.03%]
金@四氧化三铁@聚乙二醇纳米立方体作为光热治疗的光活性剂：一种体外研究方法
Aleksandra Wolińska,Marcin Drozd,Barbara Buchalska et al.
Aleksandra Wolińska et al.
Photothermal therapy (PTT) is an emerging cancer treatment that utilizes near-infrared (NIR) light and photoactive agents to induce localized hyperthermia, leading to cancer cell destruction. Magnetic nanoparticles (MNPs) with plasmonic pro...