Enhancing oxime efficacy into brain using ultrasound to counteract nerve agent exposure [0.03%]
利用超声波提高肟类物质在脑内的效力以对抗神经毒剂中毒
Lépinard Lucie,Leterrier Sarah,Jourdain Laurène et al.
Lépinard Lucie et al.
Organophosphates (OP) found in pesticides and chemical weapons irreversibly inhibit acetylcholinesterases (AChE) and cause toxic accumulation of acetylcholine throughout the organism. Due to their lipophilicity, OP easily cross the blood-br...
Inhibitory effects of kukoamine B on adipogenesis and lipid accumulation in vitro and obesity in vivo [0.03%]
化合物kukoamine B体外抑制脂肪生成和体内改善肥胖的作用研究
Kang-Il Oh,Su-Jin Lee,Jeonghyun Kim et al.
Kang-Il Oh et al.
Obesity, characterized by excessive adipose tissue accumulation, is an important risk factor for the development of several chronic conditions, including cardiovascular disease, type 2 diabetes mellitus, and hypertension. The present study ...
Magnolol facilitates mitochondrial-peroxisome dysfunction and induces oxeiptosis in lung cancer cells following transfer via tunneling nanotubes [0.03%]
大根素通过纳米管转移促进肺癌细胞线粒体-过氧化物酶体功能障碍并诱导细胞死亡
Meng-Hsuan Cheng,Hsiao-Hsuan Wang,Mo Da-Sang Hua et al.
Meng-Hsuan Cheng et al.
Recent therapeutic advances have improved survival rates for patients with lung cancer. However, drug resistance remains a significant challenge and is closely linked to mitochondrial alterations in lung cancer cells. Magnolol, a compound e...
Myeloid-specific deficiency of group VIA calcium-independent phospholipase A2 preconditions myeloid cells for injury resolution after acetaminophen exposure [0.03%]
髓系细胞特异性缺乏组VIA钙非依赖型磷脂酶A2使髓系细胞在暴露于对乙酰氨基酚后预适应损伤修复
Feng Xu,Chutima Jansakun,Gang Li et al.
Feng Xu et al.
Genetic PLA2G6 variants are associated with C-reactive protein in humans. Myeloid-specific PLA2G6-deficient (Pla2g6M-/-) mice show increased hepatic myeloperoxidase and recruitment of granulocytes in response to lipopolysaccharide (LPS). We...
Inhibition of the PI3K/AKT signaling pathway contributes to the anti-renal cell carcinoma effects of deoxyelephantopin [0.03%]
PI3K/AKT信号传导途径的抑制对冬凌草甲素抗肾细胞癌的作用有贡献
Jinjin He,Lut Yi Wong,Si Chen et al.
Jinjin He et al.
Renal cell carcinoma (RCC) is the most common kidney cancer. Despite advances in treatment, current therapeutic strategies are often limited by side effects, drug resistance, and low response rates, necessitating alternatives for RCC treatm...
Mechanistic insights into the protective potential of ambrisentan against L-arginine induced acute pancreatitis and multiorgan damage (role of NRF2/HO-1 and TXNIP/NLRP3 pathways) [0.03%]
阿米舒坦对L-精氨酸诱导的急性胰腺炎和多器官损害保护作用的机制研究（NRF2/HO-1和TXNIP/NLRP3通路的作用）
Khaled H Almutary,Marwa S Zaghloul,Manar A Nader et al.
Khaled H Almutary et al.
Acute pancreatitis (AP) is an abrupt inflammation of the pancreatic tissue. The severity of AP varies from mild and self-limiting to severe, potentially fatal, and can affect several organ systems. The most severe type of AP causes multiple...
Polystyrene microplastic induced airway hyper-responsiveness, and pulmonary inflammation are mitigated by bronchom treatment in murine model of lung disease [0.03%]
聚苯乙烯微塑料诱导的气道高反应性和肺部炎症可通过支气管药物治疗缓解：小鼠模型研究
Acharya Balkrishna,Aakanksha Tiwari,Sandeep Sinha et al.
Acharya Balkrishna et al.
Microplastics are global menace-associated with respiratory damages. The objective of this study was to investigate the airway hyper-responsiveness (AHR) and inflammation induced by polystyrene microplastic (PSMPs) in male C57BL/6 mice and ...
Levosimendan mitigates renal fibrosis via TGF-β1/Smad axis modulation in UUO rats [0.03%]
莱维西孟丹通过调节UUO大鼠TGF-β1/Smads轴来缓解肾纤维化的作用
Rohan Bhadange,Neha Dagar,Anil Bhanudas Gaikwad
Rohan Bhadange
Chronic kidney disease (CKD) is characterized by kidney fibrosis involving epithelial-mesenchymal transition (EMT), and extracellular matrix (ECM) accumulation, and often leads to end-stage kidney disease (ESKD). Currently, available therap...
Neuropeptide Y receptors 1 and 2 as molecular targets in prostate and breast cancer therapy [0.03%]
神经肽Y受体1和2作为前列腺癌和乳腺癌治疗的分子靶点
Katarina Tomić,Nina Kostevšek,Sergio Romeo et al.
Katarina Tomić et al.
Recent advances have revealed the overexpression of Neuropeptide Y (NPY) receptors in multiple cancers, positioning them as attractive molecular targets for cancer diagnostics and therapeutics. Despite this, a comprehensive roadmap for the ...
A novel butyrylcholinesterase inhibitor induces antidepressant, pro-cognitive, and anti-anhedonic effects in Flinders Sensitive Line rats: The role of the ghrelin-dopamine cascade [0.03%]
一种新型丁酰胆碱酯酶抑制剂在弗林德斯敏感系大鼠中诱导抗抑郁、促认知和抗欣快效应：生长激素释放肽-多巴胺级联的作用
Nadia Olivier,Brian H Harvey,Stanislav Gobec et al.
Nadia Olivier et al.
Background and purpose: Major depressive disorder (MDD) is often treatment resistant, particularly in addressing anhedonia and cognitive deficits. Novel pharmacological strategies are needed. While butyrylcholinesterase, ...