Generation of the Extractables Profile for an Elastomeric Material and Investigation of the Accumulation Behavior of Targeted Leachables Including Bis(2,2,6,6-tetramethyl-4-piperidyl) Sebacate (Tinuvin 770) and a Related Substance [0.03%]
用于生成弹性体提取物档案的成分配伍及针对目标萃取物（包括双（2，2，6，6-四甲基-4-哌啶基）癸二酸酯（Tinuvin 770）和类似物质）的累积行为研究
James Story,Martha Gill,Norman Liu et al.
James Story et al.
The organic extractables profile of a synthetic polyisoprene material being considered for use as a closure on a bag-type packaging system has been delineated. The predominant organic extractables associated with the test material were bis(...
Screening of counterfeit cephalosporin and discrimination from penicillins by high-throughput chemical color tests [0.03%]
高效快速筛选假头孢和区分真菌烯酸类抗生素的化学显色法筛查假冒伪劣头孢类药物及与青霉素类的区别
B K Singh,D V Parwate,S K Shukla
B K Singh
To combat the global upsurge in counterfeiting of antibiotics, rapid screening tests offering identification and binary (yes/no) information are required. Cephalosporins are susceptible to counterfeiting due to high prescription rates and p...
Preparation and stability of diallyl trisulfide self-assembled micellar injection [0.03%]
1,2-二丙烯基-3-硫醇硫酸钠胶束注射液的制备及稳定性研究
Xiulan Ju,Shixuan Zhang,Qing Wang et al.
Xiulan Ju et al.
Diallyl trisulfide (DATS) has shown various biological activities, such as antimicrobial, antihyperlipidemic, antithrombotic, and anticancer effects. It is a highly water insoluble thioether compound, which irritates blood vessels and degra...
Reducing hospital-acquired infection by quantitative risk modeling of intravenous bag preparation [0.03%]
定量风险评估介入静脉输液袋的准备以减少医院内感染
Edward C Tidswell,Jim Rockwell,Marc-Oliver Wright
Edward C Tidswell
Vascular access of patients by peripheral and central venous catheters for the delivery of sterile or aseptically manufactured parenterals is commonly regarded as one of the major causes of blood stream infections. Rigorous evaluation and m...
Kurt Brorson
Kurt Brorson
How and Why Would You Do a Pressure Holding Test on an Aseptic Installation for which You Want to Check the Integrity? Theory and Practical Example [0.03%]
无菌安装完整性检测中的保压测试如何以及为什么要做？理论与实际案例分析
Olivier Chancel,Raoul Grissely,Magnus Stering et al.
Olivier Chancel et al.
This paper uses the Boyle-Mariotte Law to restate a few general principles and applies them to rationalise pressure holding tests on sterile installations. The authors offer a methodology to achieve this, as well as a few mathematical model...
Impact of Different Elastomer Formulations on Moisture Permeation through Stoppers Used for Lyophilized Products Stored under Humid Conditions [0.03%]
不同胶塞配方对湿度环境下冻干产品用胶塞水分渗透的影响
Hitoshi Sasaki,Jun Kikuchi,Terutoshi Maeda et al.
Hitoshi Sasaki et al.
The purpose of this study was to evaluate the effect of moisture permeability of different elastomer formulation stoppers, which had different moisture absorption abilities, on the increase of moisture content inside lyophilized vials durin...
Thermosensitive Drug Permeation through Liquid Crystal-Embedded Cellulose Nitrate Membranes [0.03%]
温敏药物通过嵌入液晶的硝基纤维素膜的渗透研究
Afrouz Yousefi,Elham Khodaverdi,Fatemeh Atyabi et al.
Afrouz Yousefi et al.
In this study, the application of thermotropic liquid crystals embedded in cellulose nitrate membranes as on-off drug permeation control in response to temperature changes is described. Two low-molecular-weight liquid crystals, n-pentyl-cya...
Matrix-type transdermal drug delivery system of trandolapril: in vitro and ex vivo characterization [0.03%]
雷诺普利矩阵型透皮给药系统：体外和组织体外评价
Mamatha Tirunagari,Venkateswara Rao Jangala,Mukkanti Khagga et al.
Mamatha Tirunagari et al.
The purpose of the investigation was to develop and evaluate matrix-type transdermal drug delivery systems (TDDSs) of trandolapril. Matrix-type TDDSs of trandolapril were prepared by solvent evaporation technique. Eight formulations (compos...
Comparison of solute-binding properties of plastic materials used as pharmaceutical product containers [0.03%]
药品包装容器用塑料材料溶质吸附性能比较研究
Dennis Jenke,Tom Couch,Amy Gillum
Dennis Jenke
Material/water equilibrium binding constants (E(b)) were determined for 11 organic solutes and 2 plastic materials commonly used in pharmaceutical product containers (plasticized polyvinyl chloride and polyolefin). In general, solute bindin...