Lentiviral vector-mediated genetic modification of cell substrates for the manufacture of proteins and other biologics [0.03%]
lentivirus载体介导的细胞基质基因改造以生产蛋白质及其他生物制品
Lajos Baranyi,Andre Roy,Heather D Embree et al.
Lajos Baranyi et al.
Transduction with Lentiviral vectors has been shown to be the most efficient method for the stable delivery of nucleic acid sequences into mammalian cells. Lentiviral vectors have been widely used in research and have recently shown success...
John Petricciani
John Petricciani
The acceptability of animal cell substrates for the manufacture of biological products, especially vaccines, has been an issue in one form or another since the development of cell cultures in the 1950s. Here the major cell substrate events ...
Kathryn King,Michael Wiebe;Cell Substrate Task Force
Kathryn King
Govind Rao
Govind Rao
A novel method of characterizing medicinal drug aerosols generated from pulmonary drug delivery devices [0.03%]
一种表征肺部药物输送装置产生医药气溶胶的新方法
Mohammed Ali
Mohammed Ali
A novel method for analyzing electromechanical properties (e.g., size, electrostatic charge, polarity) of therapeutic aerosols produced by four different commercially available pressurized metered dose inhalers (pMDIs), including Albuterol...
Evaluation of the ScanRDI(R) as a Rapid Alternative to the Pharmacopoeial Sterility Test Method: Comparison of the Limits of Detection [0.03%]
评估ScanRDI作为快速替代药典无菌检测方法的价值：检出限比较
Ron Smith,Mark Von Tress,Cheyenne Tubb et al.
Ron Smith et al.
Two sterility test methods, the ScanRDI® rapid sterility test and the United States Pharmacopeia/European Pharmacopoeia/Japanese Pharmacopoeia (USP/EP/JP) compendial sterility test, were compared with respect to the limits of detection for...
Synthesis, characterization, and in vitro drug release study of methacrylate diclofenac conjugate as macromolecular prodrug [0.03%]
甲基丙烯酸盐类(diclofenac)缀合物的合成、表征及体外释药研究
Neeraj Agrawal,M J N Chandrasekar,U V S Sara et al.
Neeraj Agrawal et al.
Diclofenac was covalently coupled to 2-hydroxyl ethyl methacrylate (HEMA) to get a monomeric drug derivative of diclofenac. This monomer was subjected to radicular polymerization to get poly(diclo-EMA) conjugate. The in vitro drug release s...
Effect of penetration enhancers on gel formulation of Zidovudine: in vivo and ex vivo studies [0.03%]
透皮吸收促进剂对齐多夫定凝胶剂型的增效作用：体内及体外研究
Varsha Pokharkar,Sheetal Dhar,Nripendra Singh
Varsha Pokharkar
To overcome many challenges associated with antiretroviral drug therapy, novel drug delivery systems present an opportunity for formulation scientists to improve the management of patients with HIV/AIDS. The purpose of this study was to pre...
Studies on Viral Disinfection: An Evaluation of Moist Heat Disinfection for HBV by Using A0 Concept Defined in ISO 15883-Washer-Disinfectors [0.03%]
关于病毒灭活的研究——采用ISO15883标准中的A0概念评估HBV的湿热灭活效果
Yushi Uetera,Kunio Kawamura,Hiroyoshi Kobayashi et al.
Yushi Uetera et al.
International Organization for Standardization (ISO) 15883 for washer-disinfectors has introduced the A(0) concept to allow comparison of the lethality of moist heat processes. The A(0) value is the equivalent disinfection time in seconds a...
Preparation and characterization of papaverine-loaded poly[(r)-3-hydroxybutyrate] membranes to be used in the prevention of vasospasm [0.03%]
用于预防血管痉挛的硫酸软骨素修饰的聚（R）-3-羟基丁酸膜的制备及表征
Eylem Güven,Esref Oguz Güven,Cem Bayram et al.
Eylem Güven et al.
The objective of this study is the preparation and characterization of poly[(R)-3-hydroxybutyrate] (PHB) membrane loaded with a vasodialative agent (i.e., papaverine hydrochloride) as a blood vessel coverage strip to be used in the preventi...