Joseph M Barakat,Matthew Hancock
Joseph M Barakat
Needle clogging in prefilled syringes can impede drug product injection and negatively impact drug product quality. Computer simulations provide a useful tool to understand clogging mechanisms and elucidate design strategies to minimize or ...
Application of Modeling as a Tool for Early Derisking of Parenteral Delivery, from the Primary Container to the Tissue [0.03%]
模拟技术在注射给药剂型早期风险评估中的应用——从主容器到组织
Ludovic Gil,Christopher Basciano,Sean McGrath et al.
Ludovic Gil et al.
In silico modeling of subcutaneous injections is a promising tool to derisk and optimize the development of injections systems and improve preliminary understanding of the injectability of drugs. Such modeling can be leveraged early in deve...
Bridging the Gap-Ensuring Digital End-to-End PFS Integrity via an RFID-Based Seal: Holistic Digitalization of Inventory Management and Diversion Prevention of Hospital Drugs [0.03%]
从端到端数字防篡改完整性保证的视角探讨基于RFID封条的智慧医院药品管理与流向监管系统
Sebastian Muenscher
Sebastian Muenscher
RFID technology is mainstream in retail where apparel is tracked and inventory is managed with digital reader systems. All items at e.g. Walmart, Nordstrom and H&M are equipped with an RFID tag. Thus, warehouse managers and sales staff have...
A User-Preference Study on an Ophthalmic Injection Device to Facilitate Microliter Dosing for Intravitreal Injections [0.03%]
一种用于玻璃体腔注射微升给药的眼科注射装置的用户偏好研究
Reza Abedian,Juergen Pfrang,Simon Buerdel et al.
Reza Abedian et al.
This work focused on understanding the current practice of the intravitreal injections (IVIs) and existing challenges for both patients and healthcare professionals with the ultimate goal of developing a combination device concept for intra...
William J Davies
William J Davies
We're starting to see a huge shift in the healthcare industry towards sustainability, with stakeholders throughout the sector aiming to drive down emissions and reduce environmental impacts. This graphic focuses on device design, and applie...
Per- and Polyfluoroalkyl Substances (PFAS) in Primary Packaging and the Proposed Ban in the European Union [0.03%]
欧盟拟议的禁令范围内的含氟聚合物初级包装中的全氟和多氟烷基物质(PFAS)
Taras T Bredel,John Adamsen,Torben Helmer
Taras T Bredel
In February 2023 a restriction proposal to the European Chemicals Agency (ECHA) was submitted by five member countries of the European Union proposing a substantial restriction under the Registration, Evaluation, Authorization and Restricti...
Coring and fragmentation of elastomeric needle shield in a pre-filled syringe [0.03%]
预充式注射器胶塞护针罩的穿刺与分段试验方法研究
Sahab Babaee,Sean Teller,Kavin Kowsari et al.
Sahab Babaee et al.
Elastomeric components such as closures and stoppers play key roles in providing container closure integrity (CCI), supporting a portfolio of injectable combination products and primary containers including needle shields (NS) in prefilled ...
Analysis of virus clearance for biotechnology manufacturing processes from early to late phase development [0.03%]
生物技术制造工艺从早期到晚期开发阶段的病毒清除分析
Opeyemi O Ajayi,Jackie L Cullinan,Innara Basria et al.
Opeyemi O Ajayi et al.
The risk for virus contamination in biotechnology products (e.g., monoclonal antibodies, fusion proteins, or antibody-drug conjugates) derived from mammalian cell lines is a safety concern that must be evaluated from the early stages of dev...
Mechanical Container Closure Integrity Test: A Method for Cartridge Systems [0.03%]
机械容器密封完整性测试： cartridges系统的检测方法
Michael W Foubert,Benoit Lux,Julie Bourguard et al.
Michael W Foubert et al.
A cartridge container closure integrity control strategy may leverage a combination of test methods to ensure drug products in the assembled container system are protected from an exchange with the external environment. These methods provid...