Statistical approaches to analyzing HIV-1 neutralizing antibody assay data [0.03%]
用于分析HIV-1中和抗体测定数据的统计方法
Xuesong Yu,Peter B Gilbert,Catarina E Hioe et al.
Xuesong Yu et al.
Neutralizing antibody assays are widely used in research toward development of a preventive HIV-1 vaccine. Currently, the neutralization potency of an antibody is typically quantified by the inhibitory concentration (IC) values (e.g., IC50)...
Thomas M Braun,Nan Jia
Thomas M Braun
Combining Multiple Markers to Improve the Longitudinal Rate of Progression-Application to Clinical Trials on the Early Stage of Alzheimer's Disease [0.03%]
结合多种标记物以改善纵向进展速率测定的应用——阿尔茨海默病早期临床试验的例子
Chengjie Xiong,Gerald van Belle,Kewei Chen et al.
Chengjie Xiong et al.
Clinical trials on early stage Alzheimer's disease (AD) are reaching a bottleneck because none of the current disease markers changes appreciably early in the disease process and therefore a huge sample is required to adequately power such ...
Katherine Odem-Davis,Thomas R Fleming
Katherine Odem-Davis
Evaluation of non-inferiority is based on ruling out a threshold for what would constitute unacceptable loss of efficacy of an experimental treatment relative to an active comparator "Standard". This threshold, the "non-inferiority margin",...
Bayesian inference on risk differences: an application to multivariate meta-analysis of adverse events in clinical trials [0.03%]
基于风险差的贝叶斯推断及其在临床试验不良事件多变量meta分析中的应用
Yong Chen,Sheng Luo,Haitao Chu et al.
Yong Chen et al.
Multivariate meta-analysis is useful in combining evidence from independent studies which involve several comparisons among groups based on a single outcome. For binary outcomes, the commonly used statistical models for multivariate meta-an...
Comparing Two Exponential Distributions Using the Exact Likelihood Ratio Test [0.03%]
利用精确似然比检验比较两个指数分布
Gang Han,Michael J Schell,Jongphil Kim
Gang Han
The exact two-sided likelihood ratio test for testing the equality of two exponential means is proposed and proved to be the uniformly most powerful unbiased test. This exact test has advantages over two alternative approaches in that it is...
Chengjie Xiong,Jingqin Luo,Feng Gao et al.
Chengjie Xiong et al.
Randomized start and withdrawal designs have been recently proposed to test the disease-modifying agents on Alzheimer's disease (AD). This article provides methods to determine the optimum parameters for these designs. A general linear mixe...
Estimation of AUC or Partial AUC under Test-Result-Dependent Sampling [0.03%]
基于检验结果的抽样下AUC或部分AUC的估计
Xiaofei Wang,Junling Ma,Stephen George et al.
Xiaofei Wang et al.
The area under the ROC curve (AUC) and partial area under the ROC curve (pAUC) are summary measures used to assess the accuracy of a biomarker in discriminating true disease status. The standard sampling approach used in biomarker validatio...
Assessing Similarity to Existing Drugs to Decide Whether to Continue Drug Development [0.03%]
与现有药物相似性评价决定药物去留
Guoguang Julie Ma,Eric Chi,Joseph G Ibrahim et al.
Guoguang Julie Ma et al.
Developing a drug requires large investments, over many years, with dramatic increases in development costs at later stages. Thus, one wants to make a No Go decision on a compound early, unless evidence continues to suggest that the project...
The Zero-truncated Poisson with Right Censoring: an Application to Translational Breast Cancer Research [0.03%]
截尾的泊松分布与右删失：在乳腺癌转化研究中的应用
Hung-Wen Yeh,Byron Gajewski,Purna Mukhopadhyay et al.
Hung-Wen Yeh et al.
We propose to analyze positive count data with right censoring from Behbod et al. (2009) using the censored zero-truncated Poisson model (CZTP). The comparison in truncated means across subgroups in each cell line is carried out through a l...