A Simple and Highly Sensitive Liquid Chromatographic-Mass Spectrometric Method for the Determination of Itraconazole and Its Major Metabolite in Human Plasma and Its Application to a Bioequivalence Study [0.03%]
一种简单、灵敏的人血浆中伊曲康唑及其主要代谢产物的液相色谱-质谱测定方法及在生物等效性研究中的应用
Hamed Hamishehkar,Rasoul Hosseinpour,Ladan Dayani et al.
Hamed Hamishehkar et al.
Itraconazole is an oral triazole antimycotic drug. Bioequivalence studies are cornerstones for the approval of generic drug development globally. The present study describes a simple, sensitive and economical LC-MS/MS method for the determi...
Streamlined Sample Cleanup: Small Molecule Fractionation and Extraction Via Low-Volume Polymer Monolithic Columns for In-Line Analysis [0.03%]
在线分析中通过低体积聚合物整体柱进行小分子分级和萃取的样品净化流程简化方法
Ischa Bremer,Charles Clark,Bert Wouters et al.
Ischa Bremer et al.
Polymer monoliths are stationary-phase materials for liquid chromatography and solid-phase extraction. Their porous structure, tuneability and simple synthesis enable tailoring to specific analysis requirements in analytical chemistry. Typi...
Genetic Neural Network-Assisted Natural Deep Eutectic Solvent Extraction for Enhanced Bioactive Yield from Folium Mori with Cytotoxicity Profiling [0.03%]
基因神经网络辅助天然深共熔溶剂提取优化桑叶生物活性成分产率及其抗细胞毒性研究
Yanxia Zhou,Jinglin Shen,Hongmei Chen et al.
Yanxia Zhou et al.
Natural deep eutectic solvents (NaDESs) was efficient and green for componential extraction of traditional Chinese medicine compared to conventional organic solvents. In this study, a total of nine NaDESs were synthesized and screened, and ...
Simultaneous Bioanalytical Method Development and Validation of Navitoclax and Doxorubicin in Rat Plasma Using UHPLC-HESI-LTQ-MS [0.03%]
超高效液相色谱-加热电喷雾离子化-线性加速检测器-质谱法在大鼠血浆中同时进行Navitoclax和Doxorubicin的生物分析方法开发与验证
Nitesh Rai,Deepak Kumar,Parul Sharma et al.
Nitesh Rai et al.
A simple, sensitive, and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was successfully developed and validated to determine navitoclax and doxorubicin in rat plasma. Ketoconazole and daunorubicin were employed a...
Simultaneous Analysis of Cyproconazole and Tebuconazole in Suspension Concentrate Formulation by Reverse-Phase High-Performance Liquid Chromatography [0.03%]
反相高效液相色谱法同时分析悬浮剂中环丙唑醇和氟醚唑
Sahadev Katam,Prasad Munipalli,Bhavani Balram et al.
Sahadev Katam et al.
A novel and validated reverse-phase high-performance liquid chromatography (RP-HPLC) approach was established for the concurrent measurement of cyproconazole (CYP) isomers and tebuconazole (TBZ) in suspension concentrate (SC) agrochemical f...
Optimized Simultaneous Estimation of Metformin, Teneligliptin, and Pioglitazone in Tablet and Bulk Drug: A Box-Behnken Design Approach for RP-UFLC Method Development and Validation [0.03%]
用于开发和验证RP-UFLC方法的Box-Behnken设计方法，优化估算片剂和原料药中盐酸二甲双胍，那格列汀和吡格列酮的同步估算
Jignesh Panchal,Jayesh Dhalani
Jignesh Panchal
The combination of metformin (MET), teneligliptin (TEN), and pioglitazone (PIO) is newest fixed-dose combination for the treatment type 2 diabetes launched in India. An accurate, rapid, and cost-effective reversed phase ultra-fast liquid ch...
Method for Simultaneous Determination of Amino Acid Surfactants Sodium N-Lauroylsarcosinate and Sodium Methyl Cocoyl Taurate in Personal Care Products, by Using High Performance Liquid Chromatography [0.03%]
高效液相色谱法同时测定个人护理产品中的月桂基氨基酸和甲基椰油酰基牛磺酸钠的方法研究
Kumar Thangarathinam,Udhayachandran Narayanan
Kumar Thangarathinam
Sodium N-lauroylsarcosinate (NLS) and sodium methyl cocoyl taurate (SMCT) are widely used in sulfate free personal care products. We present a straightforward and highly sensitive High-Performance Liquid Chromatographic (HPLC) method for si...
Screening Method for the Determination of per- and Polyfluoroalkyl Substances (PFAS) in Textiles by Combustion and Ion Chromatography [0.03%]
燃烧结合离子色谱法筛选纺织品中含氟及多氟化合物(PFAS)的检测方法
Lihua Cao,Youchao Ding,Kai Qian et al.
Lihua Cao et al.
A screening method was developed for the determination of per- and polyfluoroalkyl substances in textiles by combustion and ion chromatography. In this work, a new type of high-temperature combustion absorption device was designed, and the ...
Analytical Development of Piperine as Herbal Reference Material from Black Pepper for Quality Control Purposes: Liquid Chromatography-Quadrupole Time-of-Flight, Nuclear Magnetic Resonance, and Thermal Analysis [0.03%]
液相色谱四极杆飞行时间、核磁共振及热分析联用测定植物参考标准品—胡椒碱的成分与发展质量控制体系研究
Swati Ramesh Pawar,Sachin Dattram Pawar,Sandeep Jat et al.
Swati Ramesh Pawar et al.
Various spices and their oleoresins are being marketed since long and it has multibillion market. One of the most often used spices is black pepper (Piper nigrum), which gets its pungent flavour from volatile chemical components, essential ...
Phytochemical Profiling, Isolation, Characterization and Quantification of Triterpenoids from Terminalia Arjuna: A Multi-Location Study Using HPLC and Statistical Analyses [0.03%]
基于高效液相色谱和统计分析的Terminalia Arjuna多产地三萜类化学轮廓、分离及定量研究
Radhika Khanna,Gaurav Pandey,Santan Barthwal et al.
Radhika Khanna et al.
Terminalia arjuna is a widely recognized medicinal tree known for its diverse pharmacological properties, particularly its cardioprotective effects. This study aimed to quantify two key bioactive triterpenoids, arjungenin and arjunic acid, ...