Compositional and Functional Metabolic Shifts in the Endometrial Microbiota of Cows (Bos taurus) During the Transition Period: A Metagenomic Next-Generation Sequencing Approach [0.03%]
基于代谢组和功能组的牛子宫微生物群落变化分析：下一代测序方法
Elena A Yildirim,Georgi Yu Laptev,Daria G Tiurina et al.
Elena A Yildirim et al.
Background: Significant alterations in feeding, housing, and physiology are observed in dairy cows during the transition period (3 weeks pre- and post-calving), in addition to changes in the composition and abundance of t...
Insights Into the Characterization and Application of Pseudomonas taetrolens [0.03%]
解聚四色假单胞菌的特性及应用研究进展
Inga Sarenkova,Inga Ciprovica,Manuel Rendueles
Inga Sarenkova
Pseudomonas taetrolens is a highly versatile microorganism that has gained significant attention in biotechnology due to its metabolic adaptability and ability to thrive in diverse environmental conditions. Thus, since P. taetrolens efficie...
Small Helper Ti-plasmid Coexisting With the A281virF Gene Encoding an F-Box-Like Protein Improves the Efficiency of T-DNA Transfer From Agrobacterium Cells to Plant Cells [0.03%]
共表达A281 virF基因的Ti质粒可提高农杆菌介导的T-DNA转移效率
Nonna Fatima H Abello,Nobuyuki Takatani,Makiko Aichi et al.
Nonna Fatima H Abello et al.
Background: Transient transformation is a convenient and less time-consuming method for investigating gene functions compared with production of stable transformants. Most systems for Agrobacterium-mediated plant transfor...
AAV9-Mediated Targeting of Defined Neuronal Populations in Spinal Cord Through Intrathecal Injection [0.03%]
腰椎给药的AAV9脊髓内注射及其对特定神经元种类的靶向性研究
Tatyana Ageeva,Rezeda Shigapova,Eldar Davletshin et al.
Tatyana Ageeva et al.
Background: Adeno-associated viruses (AAVs) are established vectors for efficient gene delivery to the central nervous system (CNS). Increasingly, strategies aim to restrict transduction to specific neuronal subtypes defi...
Progress in Bioengineering: An Extensive Examination of State-of-the-Art Innovations in the Development of Artificial Corneas [0.03%]
生物工程进展：人工角膜开发领域最新创新技术的全面考察
Marco Zeppieri,Caterina Gagliano,Fabiana D&#x;Esposito et al.
Marco Zeppieri et al.
Artificial corneas represent a significant breakthrough in addressing global corneal blindness, impacting millions of individuals worldwide. The scarcity of donor tissue and the complications of immune rejection necessitate the development ...
Nitrosylcobalamin Selectively Targets Tumors via Cobalamin Uptake and Lysosomal Processing [0.03%]
硝基钴胺素通过钴胺素摄取和溶酶体加工选择性靶向肿瘤
Joseph A Bauer,Annette M Sysel
Joseph A Bauer
Background: Nitrosylcobalamin (NO-Cbl) is a vitamin B12 analog designed to exploit the "Trojan horse" vulnerability created by the heightened need of cancer cells for cobalamin and one-carbon metabolism. Building on our r...
Navigating the Landscape of Antibody Drug Conjugates: Current Trends and Future Research Prospects in Acute Myeloid Leukemia [0.03%]
抗体药物偶联物在急性髓系白血病中的现状和未来研究前景展望
Aayushi C Shah,Sunayna G Saluja,Jeel D Trivedi et al.
Aayushi C Shah et al.
Acute myeloid leukemia (AML) is a hematologic malignancy with a poor prognosis and high relapse rates, especially in high-risk patients and older adults. Conventional treatment modalities confer limited benefit, specifically in relapsed and...
Fructose Metabolism and Disease Mechanisms: From Nutritional Excess to Obesity and Multiorgan Pathophysiology [0.03%]
果糖代谢与疾病机制：从营养过剩到肥胖及多器官病理生理学
Evelyn Sharon Sukumaran,Nila Ganamurali,Aishwarya Pm et al.
Evelyn Sharon Sukumaran et al.
Excessive fructose consumption has emerged as a critical driver of obesity and metabolic dysfunction, with far-reaching implications for multiple organ systems. This review synthesizes current evidence on the biochemical and molecular pathw...
Consumption of Water Similar to Martian Water in Terms of Deuterium Content by Mammals Leads to the Development of an Adaptation Syndrome and Activation of Protective Mechanisms Against Stress [0.03%]
哺乳动物摄入氘含量类似火星水的水会导致适应综合征和激活应对压力的保护机制
Stanislav Kozin,Alexandr Kravtsov,Oksana Lyasota et al.
Stanislav Kozin et al.
Background: Deuterium is unevenly distributed in natural waters, while the same applies to the content of deuterium in ice on Mars. Moreover, changes in the deuterium content of drinking water are known to affect the bodi...
Repurposing Finasteride and Serotonin Reuptake Inhibitors as Novel Antimicrobials: A Dual-Action Approach to Target Bacterial and Fungal Pathogens [0.03%]
氟他胺和血清素再摄取抑制剂作为新型抗菌药物的再定位：针对细菌和真菌病原体的双重作用方法
Reilly Taylor,Stefani Capasso-Villanueva,Anderson Jeon et al.
Reilly Taylor et al.
Background: The global rise of antimicrobial resistance necessitates the development of innovative therapeutic strategies beyond traditional antibiotics. Drug repurposing offers a time- and cost-effective approach by iden...