Silencing TGF-β3 Alleviates Recurrent Spontaneous Abortion Inflammation in Mice: the Importance of Treg/Th17 Cell Balance [0.03%]
沉默TGF-β3缓解小鼠复发性流产炎症：Treg/Th17细胞平衡的重要性
Li Peng,Milan Yang,Xiaoyan Luo
Li Peng
Background: Recurrent spontaneous abortion (RSA), also known as repeated miscarriage, refers to the consecutive loss of pregnancy three times or more before the fetus reaches viability. In this study, we aimed to investig...
Research Progress on Alzheimer's Disease Biomarkers Based on the ATX(N) Framework [0.03%]
基于AT(X)(N)构架的阿尔茨海默病生物标志物研究进展
Haojun Cao,Wenxuan Zhang,Jixin Lin et al.
Haojun Cao et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Early diagnosis and treatment of AD are of paramount importance, with the concept of biomarkers being intrinsically linked to diagnosis and therapy. Biomarkers are indice...
Channels out of Order: A Review of Central and Peripheral Nervous System Channelopathies [0.03%]
离散的通道：中枢和外周神经系统的离子通道病综述
Lorenzo Verriello,Marco Belluzzo,Giada Pauletto et al.
Lorenzo Verriello et al.
A vast range of neurological conditions impacting the central and peripheral nervous system are caused by ion channel dysfunctions, which are collectively referred to as channelopathies. These disorders, which are frequently autoimmune or g...
Tailoring Pharmacological Treatment in Cardiogenic Shock: A Narrative Review [0.03%]
心源性休克中药物治疗的个体化选择：一项叙述性综述
Simone Pasquale Crispino,Andrea Segreti,Vincenzo Nafisio et al.
Simone Pasquale Crispino et al.
Cardiogenic shock (CS) is a critical condition marked by end-organ hypoperfusion and sustained hypotension, necessitating the use of inotropic or vasoactive agents for hemodynamic support. It is the leading cause of mortality in patients wi...
The Ubiquitin Code in Disease Pathogenesis and Progression: Composition, Characteristics and its Potential as a Therapeutic Target [0.03%]
疾病的发病与进展中的泛素代码：组成、特征及其作为治疗靶点的潜力
Ji Su Lee,Hye Yeon Kim,Yong Tae Kwon et al.
Ji Su Lee et al.
Conjugation of substrate proteins with ubiquitin (Ub), a 76 amino acid protein, was discovered as the first major translational modification responsible for protein degradation. Ubiquitination occurs as a cascade among ubiquitin-activating ...
Correction: Chen et al. β-Sitosterol Enhances Lung Epithelial Cell Permeability by Suppressing the NF-κB Signaling Pathway. Discovery Medicine. 2023; 35(179): 946-955 [0.03%]
陈等人文章勘误：β-谷甾醇通过抑制NF-κB信号通路增强肺上皮细胞通透性。发现医学。2023；35（179）：946-955
Xingdong Chen,Juan Chen,Yi Ren et al.
Xingdong Chen et al.
Correction of Discovery Medicine 2023, 35 (179) https://www.discovmed.com/EN/10.24976/Discov.Med.202335179.90 The authors wish to make the following correction to this paper [1]: The authors would like to correct the name of their affiliate...
Published Erratum
Discovery medicine. 2025 Jan;37(192):202. DOI:10.24976/Discov.Med.202335179.90corr 2025
Fruit Acid Inhibits UV-Induced Skin Aging via PI3K/Akt and NF-κB Pathway Inhibition [0.03%]
果酸通过抑制PI3K/Akt和NF-κB信号通路来缓解紫外线诱导的皮肤老化损伤
Ben Wang,Jie Dong,Fang Liu
Ben Wang
Backgrounds: Ultraviolet (UV) radiation-induced photoaging is a multifaceted biological process. Fruit acids have shown promise in combating photoaging. This study aims to investigate the mechanisms underlying the protect...
CKAP2L Plays a Pivotal Role in Colorectal Cancer Progression via the Dual Regulation of Cell Cycle and Epithelial-Mesenchymal Transition [0.03%]
CKAP2L在结直肠癌进展中的关键作用：通过细胞周期和上皮间质转化的双重调节机制
Qingbin Luo,Bohui Zhu,Cuilan Wang et al.
Qingbin Luo et al.
Background: Cytoskeleton-associated protein 2 like (CKAP2L) has been demonstrated to mediate the cell cycle in cancer cells. However, it is unknown whether CKAP2L impacts colorectal cancer (CRC). The purpose of this study...
Glioblastoma Stem Cells: MAP17 as a Novel Predictive Biomarker and Therapeutic Target Associated with Quiescence and Immune Evasion [0.03%]
胶质母细胞瘤干细胞：MAP17作为与静止和免疫逃避相关的新型预测生物标志物和治疗靶点
Sara Sadat Aghamiri,Rada Amin
Sara Sadat Aghamiri
Background: Glioblastoma multiforme (GBM) is one of the deadliest and most heterogeneous forms of brain cancer, characterized by its resistance to conventional therapies. Within GBM, a subpopulation of slow-cycling cells,...
Zinc Finger SWIM-Type Containing 3 Reprograms Lipid Metabolism and Drives Breast Cancer Progression [0.03%]
含锌指SWIM结构域的三维蛋白3重塑脂质代谢并驱动乳腺癌进展
Xiao Ma,Ancai Wang,Yu Wang et al.
Xiao Ma et al.
Background: Zinc finger proteins (ZNFs) have been proved to play important roles in driving the progression of breast cancer (BC), one of the most common cancers among women. This study aimed to investigate the involvemen...