GPCRs With mTOR Signaling Expressed in Gut-Brain-Immune Axis-Cells Could Contribute to the Treatment of Neurodegenerative Diseases and Immune-Related Diseases [0.03%]
胃肠脑免疫轴中的GPCRs与mTOR信号表达的细胞有可能用于治疗神经退行性疾病和免疫相关疾病
Akari Fukumoto,Naoko Suga,Moeka Nakashima et al.
Akari Fukumoto et al.
The central nervous system (CNS) and the immune system might cooperate with each other on various levels in a body. Interestingly, signaling pathways linked to several G protein-coupled receptors (GPCRs) have been shown to be involved in th...
Comparative Analysis of Anterior vs Posterior Approaches in Eyelid Ptosis Repair [0.03%]
上睑下垂矫正手术中前路与后路的对比分析
Marco Zeppieri,Vito Cazzato,Pier Luigi Surico et al.
Marco Zeppieri et al.
Eyelid ptosis, characterized by the drooping of the upper eyelid, can significantly impair vision and aesthetics. Surgical repair is often necessary, and the choice between the anterior and posterior approaches is crucial for optimal outcom...
Two Novel Variants in the LRR Domain of NLRP3 Causing Leukoencephalopathy: A Case Report [0.03%]
NLRP3蛋白LRR区导致白质脑病的两个新突变的病例报道
Zhibo Feng,Na Wu,Yuxia Shao et al.
Zhibo Feng et al.
Aim: The NLR family pyrin domain containing 3-associated autoinflammatory disease (NLRP3-AID) is a rare and heterogeneous hereditary inflammatory disorder caused by variants in the NLRP3 gene on chromosome 1q44. This cond...
Analysis of hsa_circ_0006459 and hsa_circ_0015962 Expression in Peripheral Blood Mononuclear Cells of Dengue-Infected Patients and Healthy Donors [0.03%]
登革热感染患者和健康供体外周血单核细胞中hsa_circ_0006459和hsa_circ_0015962表达的分析
Giuseppe Sberna,Eleonora Lalle,Alessandra Amendola et al.
Giuseppe Sberna et al.
Background: Although evidence exists on the potential involvement of circular RNAs (circRNAs) in the pathogenesis of several viral infections, the expression levels, and the exact role that hsa_circ_0006459 and hsa_circ_0...
The Correlation between GSK3β and miR-140 and its Effect on the Pathogenesis of Asthma [0.03%]
GSK3β和miR-140的相关性及其对哮喘发病的影响
Ting Yang,Chang Xu,Niu Ding et al.
Ting Yang et al.
Background: MicroRNAs (miRNAs) are linked to asthma progression. In this study, we aimed to decipher the functional role of miR-140 and delineate its link to the mechanism behind the progression of asthma. ...
Regulating Osteogenic Fate: How Dexamethasone Targets the CAST-CAPN1-ATP5A1 Axis in BMSCs [0.03%]
调节成骨细胞命运：地塞米松是如何作用于骨髓基质细胞中的CAST-CAPN1-ATP5A1轴的
Gang Zhong,Shiqiang Cen,Zhou Zhong et al.
Gang Zhong et al.
Background: Osteoporosis is a common systemic metabolic disease, leading to increased bone fragility and risk of fractures. Research has shown that Adenosine triphosphate (ATP) synthase, H+transporting, mitochondrial F1 c...
Study on the Application of MLPA Detection for Large Fragment Loss of Mismatch Repair Genes in Chinese HNPCC Families [0.03%]
MLPA技术检测错配修复基因大片段丢失在中国HNPCC家系中的应用研究
Meisi Huo,Yi Zhang,Hongdao Liu et al.
Meisi Huo et al.
Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disease caused by germline mutations of human DNA mismatch repair (MMR) genes. A significant proportion of HNPCC cases are attributed ...
Yupeng Shen,Chenzhi Xu,Xin Liu et al.
Yupeng Shen et al.
Background: Tumor-initiating cells (TICs) play a pivotal role in the unfavorable outcomes of laryngeal tumor proliferation, recurrence, and resistance to chemoradiotherapy. This study aims to explore the expression of CD2...
Structural Changes in Membrane Dynamics under the Action of Miltefosine [0.03%]
Miltefosine作用下膜动态的结构变化
Irina Georgieva,Sonia Apostolova,Teodora Vukova et al.
Irina Georgieva et al.
Background: Miltefosine, an alkylphosphocholine, affects lipid metabolism and cell signaling by interacting with cell membranes. In this study, we aim to demonstrate the effect of miltefosine (hexadecylphosphocholine (HeP...
Anti-Inflammatory Effect of Calycosin on Hypoxia-Induced Retinal Pigment Epithelium Cells [0.03%]
槐柳碱对缺氧诱导视网膜色素上皮细胞的抗炎作用
Tingting Zhu,Bin Wang,Wei Huang et al.
Tingting Zhu et al.
Background: Calycosin is thought to have anti-cancer and anti-inflammatory characteristics; however, more research is needed to determine how it impacts retinal pigment epithelium (RPE) cells. This study aims to explore t...