Exploring the lncRNA NEAT1/iASPP Pathway in Chordoma: Mechanisms of Proliferation Suppression and Apoptosis Induction [0.03%]
长链非编码RNA NEAT1/iASPP通路在脊索瘤中的作用机制研究：增殖抑制和凋亡诱导
Zhigang Ma,Lei Wang,Zhe Ji et al.
Zhigang Ma et al.
Background: Chordoma is a rare, primary malignant bone tumor arising from remnants of embryonic notochord tissue. While the long non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) has been implicate...
Protective Role of Cerium Oxide Nanoparticle Pretreatment in Preventing Pilocarpine-Induced Epileptic Seizures [0.03%]
纳米氧化铈预处理预防毛果芸香碱致痫的保护作用研究
Dan Yang,Shuangfeng Yang,Jingya Deng et al.
Dan Yang et al.
Background: Epilepsy is a prevalent neurological disorder characterized by transient brain dysfunction due to abnormal neuronal discharges. Oxidative stress is strongly correlated with epilepsy onset and progression and i...
Linqing Tian,Ye He,Wenli Zhang et al.
Linqing Tian et al.
Background: The management of temporomandibular disorders (TMD) remains challenging, with its underlying pathological mechanisms requiring further investigation. This study aimed to explore the effects of Botulinum Toxin ...
Investigating the Mechanisms of Esketamine in Treating Propofol-Induced Cognitive Impairment in Elderly Rats [0.03%]
艾司氯胺酮干预异丙酚致老年大鼠认知障碍的作用机制研究
Jieru Zhang,Guofeng Xu,Xiaoli Wang et al.
Jieru Zhang et al.
Background: Common cognitive impairment in the elderly may be aggravated by the anesthetic propofol, whereas the mammalian target of rapamycin protein (mTOR)-brain-derived neurotrophic factor (BDNF) pathway and autophagy ...
Sirtuin1 Promotes the Migration of Cells and Reduces the Accumulation of Extracellular Matrix in Trabecular Meshwork Cells Induced by Transform Growth Factor-β via Smads System [0.03%]
沉默信息调节因子2相关酶1促进小梁网细胞迁移并减少转化生长因子-β诱导的细胞外基质聚集的作用及机制研究
Jinjun Tie,Junhong Guo,Jiemei Yuan et al.
Jinjun Tie et al.
Background: Primary open-angle glaucoma (POAG) is one of the common types of glaucoma, an eye disease that causes irreversible blindness. Fibrosis of the trabecular meshwork (TM) caused by the accumulation of extracellula...
Celastrol Targets FANCD2 to Induce Autophagy-Dependent Ferroptosis in Hepatocellular Carcinoma Cells [0.03%]
雷公藤红素通过靶向FANCD2诱导肝癌细胞自噬依赖性铁死亡
Jici Yan,Tian Xu
Jici Yan
Background: Celastrol has been shown to inhibit hepatocellular carcinoma (HCC) progression, but the underlying mechanism is unknown. Fanconi anemia complementation group D2 (FANCD2), a ferroptosis inhibitor, promotes HCC ...
Protective Role of Protocatechuic Acid in Glioma: Modulation of Cell Growth, Migration, and Pyroptosis via NLRP3/Caspase-1/GSDMD Axis [0.03%]
原儿茶酸通过NLRP3/ caspase - 1 /GSDMD轴在胶质瘤中发挥保护作用：调节细胞生长、迁移和焦亡
Wen Zhang,Yeyan Cai,Haijun Zheng
Wen Zhang
Background: Glioblastoma is a common primary malignant tumor posing a serious threat to human life and health. Protocatechuic acid (PCA) is a natural phenolic compound with good anti-tumor activity. The study aimed to inv...
Hakan Akdere,Burak Bilir,Hasan Can Kuvan et al.
Hakan Akdere et al.
Interleukins (ILs) are a group of cytokines that regulate immune responses and inflammation, playing important roles in the pathogenesis, diagnosis, and treatment of urological diseases. This review provides an analysis of the involvement o...
Immunomodulatory Role of T Cell Immunoglobulin and Mucin Domain-3 in Cancer [0.03%]
T细胞免疫球蛋白和粘膜分子域-3在癌症中的免疫调节作用
Avinash Chaudhary,Pragya Yadav,Pratima Chaudhary et al.
Avinash Chaudhary et al.
Immune checkpoint inhibitors are one of the most promising areas in oncoimmunology research. T cell immunoglobulin and mucin domain-3 (TIM-3) expression has been linked to the advanced stages with reduced survival in several types of cancer...
Arturo Lecumberri,Hugo Arasanz,Irene Caseda et al.
Arturo Lecumberri et al.
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Advanced CRC has a poor prognosis, with treatment primarily relying on chemotherapy combined with targeted therapies. Currently, immunotherapy based on immune checkpo...