Xiaojuan Zheng,Jin Ding,Yanping Chen et al.
Xiaojuan Zheng et al.
Chromobox 4 (CBX4) is a polycomb group protein involved in epigenetic regulation via the polycomb repressive complex 1 (PRC1) and its small ubiquitin-like modifier (SUMO) ligase activity. It has been reported that CBX4 plays several oncogen...
Targeting Ferroptosis via Mitochondria Dynamics in Myocardial Ischemia/Reperfusion Injury [0.03%]
靶向线粒体动态的铁死亡在心肌缺血再灌注损伤中的作用
Alfredo Cruz-Gregorio
Alfredo Cruz-Gregorio
Myocardial infarction remains a significant worldwide public health issue, primarily owing to its mortality and morbidity rates. This condition is due to myocardial ischemia, appearing once the heart's blood flow is obstructed or significan...
Adjuvant Immunotherapy in Microsatellite Instability-High Colon Cancer: A Literature Review on Efficacy, Challenges, and Future Directions [0.03%]
微卫星不稳定型直肠癌辅助免疫治疗：疗效、挑战和未来方向的文献综述
Vasisht Karri,Santosh Nimkar,Samir M Dalia
Vasisht Karri
Colon cancer accounts for nearly 10% of all cancer diagnoses annually. Microsatellite instability-high (MSI-H) colon cancer is a particularly aggressive subtype of colon cancer that is known to have a significant number of genetic mutations...
Is SARS-CoV-2 Spike Evolution Being Retargeted at the N-Terminal Domain? [0.03%]
SARS-CoV-2刺突蛋白进化是否在N末端结构域重新定向？
Daniele Focosi,Tommaso Alfonsi,Anna Bernasconi
Daniele Focosi
Since 2020, most of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) evolution has been focused on the receptor-binding domain (RBD) of the Spike protein. Nevertheless, the N-terminal domain (NTD) of Spike has been shown to repr...
The Cerebellum as a Predictor: Recent Insights Into Cognitive Control and Extension of Kalman Filter Theory to Cognition [0.03%]
小脑的预测功能：认知控制的新见解及卡尔曼滤波理论在认知领域的扩展理论近况
Shinji Kakei,Hirokazu Tanaka,Hiroshi Mitoma et al.
Shinji Kakei et al.
Traditionally viewed as a motor control center, the cerebellum is increasingly recognized as a crucial component of a neural network that enables adaptive behavior across various domains, including cognition, affect, emotion, and social int...
The Relationship of MAPK10P Gene Polymorphism With P-Wave Peak Time and P-Wave Dispersion in Elderly Patients With Paroxysmal Atrial Fibrillation [0.03%]
MAPK10基因多态性与老年阵发性房颤患者P波终末电位时间及P波离散度的关系研究
WenYi Wang,Gang Liang,AiLin Bian et al.
WenYi Wang et al.
Background: The incidence of atrial fibrillation (AF) presents a markedly increasing trend with advancing age. Thus, with the growing population of elderly individuals, AF has emerged as a significant medical and socioeco...
Curcumin Attenuates PD-L1-Positive Neutrophil-Induced T-Lymphocyte Apoptosis and Alleviates Lung Injury During Sepsis in Rats [0.03%]
姜黄素通过下调PD-L1阳性中性粒细胞诱导的T淋巴细胞凋亡减轻大鼠脓毒症肺损伤
Jiajun Zou,Jian Guo,Guanyu Hu et al.
Jiajun Zou et al.
Objective: This study aimed to investigate the effects of curcumin (Cur) on programmed cell death 1 ligand 1 (PD-L1) expression in neutrophils from septic rats and its regulatory influence on T-lymphocyte apoptosis and lu...
Effects of Aerobic Exercise and Intermittent Fasting on Fecal Microbiome Diversity in Obese Mice [0.03%]
有氧运动和间歇性进食对肥胖小鼠粪便菌群多样性的影响
Lingfeng Yuan,Yisheng Luan,Weihao Hong et al.
Lingfeng Yuan et al.
Background: Obesity threatens human health, and interventions to reduce obesity may have important effects on the gut microbiota. This study investigated alterations in gut microbial composition in response to aerobic exe...
SPAG4 Regulates Glycolytic Metabolism in HT29 Cells as a Target via the c-MYC/SULT2B1 Pathway [0.03%]
SPAG4通过c-MYC/SULT2B1途径调节HT29细胞糖酵解代谢
Honghong He,Xuebing Zhang,Liting Zhong et al.
Honghong He et al.
Background: Glycolytic metabolism has been identified as a facilitator of tumor cell proliferation. Therefore, this study aims to investigate the mechanisms by which the sperm-associated antigen 4 (SPAG4)/cellular myelocy...
A Potential Link Between Early Onset Reactive Astrogliosis and Adult-Onset Dysfunction of Leptin Signaling in Polyubiquitin Gene Ubb Knockout Mice [0.03%]
多泛素基因Ubb敲除小鼠早期反应性星形胶质细胞病变与成年期瘦素信号功能障碍之间潜在联系的研究
Jin-Sil Bae,Sekee Yoon,Taek-Yeong Kim et al.
Jin-Sil Bae et al.
Background: Polyubiquitin gene Ubb knockout (KO) mice exhibit early onset reactive astrogliosis and adult-onset hypothalamic neurodegeneration with obesity. However, it remains unknown why the obesity phenotype only manif...