Astragaloside IV Mediates the PI3K/Akt/mTOR Pathway to Alleviate Injury and Modulate the Composition of Intestinal Flora in ApoE-/- Atherosclerosis Model Rats [0.03%]
ASTRAGALOSIDE Ⅳ通过介导PI3K/AKT/MTOR信号通路改善ApoE基因敲除动脉粥样硬化模型大鼠肠道屏障功能及肠菌群失调研究
Dongwen Sun,Yiqiang Wang,Bingyao Pang et al.
Dongwen Sun et al.
Background: Atherosclerosis (AS) is a chronic inflammatory vascular disease with a complex pathogenesis. Astragaloside IV (AST IV), the primary active component of Astragalus, possesses anti-inflammatory, antioxidant, and...
Comparative Analysis of Post-Translational Modifications of Human Serum Albumin Derived from Human Plasma and Recombinant Sources in China [0.03%]
中国国产人血浆和重组人血白蛋白的蛋白质修饰比较分析研究
Qing Liu,Zhifeng Lin,Changqing Li et al.
Qing Liu et al.
Background: The variations in sequence, three-dimensional structure, and post-translational modifications (PTMs) of human serum albumin (HSA) are crucial for its physiological functions. This study aims to analyze and com...
Comparative Study
Discovery medicine. 2024 May;36(184):1054-1069. DOI:10.24976/Discov.Med.202436184.98 2024
GSK-126 Enhances All-Trans-Retinoic Acid (ATRA) Response in Hepatocellular Carcinoma (HCC) by Upregulating RARG Expression [0.03%]
GSK-126通过上调RARG表达增强全反式维甲酸(ATRA)在肝癌细胞中的作用响应
Zhidan Liu,Yongxia Zheng
Zhidan Liu
Background: Hepatocellular carcinoma (HCC) stands out as one of the most prevalent malignant tumors globally. The combination of all-trans-retinoic acid (ATRA) with FOLFOX chemotherapy has shown promise in enhancing the p...
Whole Genome-Sequencing and Phylogenetic Analysis of Bacillus anthracis from 2019-2023 in Ningxia Hui Autonomous Region, China [0.03%]
中国宁夏回族自治区2019-2023年炭疽芽胞杆菌全基因组测序及进化分析
Ran Xian,Cong Yang,Jianwei Gao et al.
Ran Xian et al.
Background: Since 2019, the incidence of anthrax in the Ningxia Hui Autonomous Region has increased significantly compared with previous years, so in this situation the anthrax in the Ningxia region not only had a detrime...
UNC93B1 Mediates the Effects of cGAS-STING on ER Stress and Iron Death, and Reduces Renal Toxicity in Cadmium-Exposed Rats [0.03%]
UNC93B1介导cGAS-STING对镉暴露大鼠内质网应激及铁死亡的影响并减轻肾脏毒性
Renhong Liu,Liya Liu,Chan Fan et al.
Renhong Liu et al.
Background: Long-term exposure to cadmium can induce renal toxicity in rats, leading to endoplasmic reticulum (ER) stress and iron death. Notably, in cadmium-exposed rats, there is an increased expression of UNC93B1 (unc-...
Revealing a New Homozygous Variant in CYP17A1 c.908G>A (p. Gly303Asp) by Genotyping a Chinese Patient with 46, XY 17a-Hydroxylase/17,20-Lyase Deficiency and Adrenal Space-Occupying Lesion [0.03%]
通过基因分型法在中国17α-羟化酶/17,20-裂解酶缺乏症伴肾上腺占位病变的46XY患者中鉴定出一个新的CYP17A1 c.908G>A (p.Gly303Asp)纯合子变异型
Miao Wang,Xuejian Hu,Xiangyu Xu et al.
Miao Wang et al.
Background: 17α-hydroxylase/17,20-lyase deficiency (17OHD) is an autosomal recessive genetic disorder caused by a mutation of the cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1). This study reports the c...
Interferon-Gamma Release Assay Combined with Renal Indicators to Reduce the False-Negativity of Latent Tuberculosis Infection in End-Stage Renal Disease with Hemodialysis Patients [0.03%]
干扰素伽马释放试验联合肾功能指标减少维持性血液透析终末期肾脏病患者潜伏结核感染假阴性的研究
Xianglan Xuan,Heechul Park,Yun-Jeong Kang et al.
Xianglan Xuan et al.
Background: Tuberculosis (TB) is still the main cause of mortality due to a single transfectant, Mycobacterium tuberculosis (MTB). Latent tuberculosis infection (LTBI) is a condition characterized by the presence of tuber...
Hyperbaric Lidocaine Aggravates Diabetic Neuropathic Pain by Targeting p38 MAPK/ERK and PINK1/Parkin-Mediated Mitophagy Signaling Pathway [0.03%]
高压利多卡因通过靶向p38 MAPK/ERK和PINK1/Parkin介导的线粒体自噬信号通路加重糖尿病神经痛
Xiao-Lan Zheng,Ling Chen,Chen-Lu Fan et al.
Xiao-Lan Zheng et al.
Background: Diabetic neuropathic pain (DNP) is a complication of diabetes mellitus (DM). Hyperbaric lidocaine (HL), a local anesthetics drug, has neurotoxicity. The present study aims to study the effect and molecular mec...
Genotype Distribution and Prevalence of High-Risk Human Papillomavirus among Pregnant Women and Maternal-Fetal Pregnancy Outcomes in a Tertiary Hospital in Beijing, China [0.03%]
中国北京一家三级医院孕期妇女高危人乳头瘤病毒基因型分布及流行率与母胎妊娠结局的相关性研究
Yajun Liu,Shuzhen Wang
Yajun Liu
Background: High-risk human papillomavirus (HR-HPV) infection is the primary reason for cervical cancer and precancerous lesions in females. Specific immune alterations in pregnancy led to greater HR-HPV replication and r...
Observational Study
Discovery medicine. 2024 May;36(184):981-991. DOI:10.24976/Discov.Med.202436184.91 2024
Demethylation of TIMP2 and TIMP3 Inhibits Cell Proliferation, Migration, and Invasion in Pituitary Adenomas [0.03%]
垂体腺瘤中TIMP2和TIMP3去甲基化抑制细胞增殖、迁移和侵袭
Yongdong Yang,Fanjun Huang,Xiufu Wu et al.
Yongdong Yang et al.
Objective: Tissue inhibitors of matrix metalloproteinases (TIMPs) are prognostic markers in cancers. However, the role of TIMPs in DNA methylation during invasive pituitary adenoma (PA) remains unclear. The purpose of thi...