Long-Term Outcomes of the Self-Expandable Metallic Stent as a Bridge to Surgery versus Elective Surgery without Stent Placement for Colorectal Cancer: A Retrospective Cohort Study [0.03%]
桥接手术与无支架置入择期手术治疗结直肠癌的长期结局：回顾性队列研究
Bosen Zhu,Jiaxin Lin,Weilin Liao et al.
Bosen Zhu et al.
Background: The uncertainty surrounding whether delaying surgery after self-expandable metal stent (SEMS) placement for neoplastic stricture can yield similar oncologic outcomes as elective surgery remains. This study aim...
Comparative Study
Discovery medicine. 2024 Jun;36(185):1189-1198. DOI:10.24976/Discov.Med.202436185.109 2024
Astaxanthin Expedites the Healing of Acute Skin Wounds in Rats by Facilitating M2 Macrophage Polarization and Enhancing Collagen Secretion [0.03%]
虾青素通过促进M2型巨噬细胞极化和增强胶原蛋白分泌来加速大鼠急性皮肤伤口愈合作用研究
Hong-Dong Gao,Hui-Lin Zheng
Hong-Dong Gao
Background: Facilitating the healing process of skin post-trauma is crucial for minimizing infection risks and reinstating normal tissue functionality. While past studies have established astaxanthin (ASX) as an effective...
CRISPR/Cas9 System with Dual gRNAs Synergically Inhibit Hepatitis B Virus Replication [0.03%]
双gRNA CRISPR/Cas9系统协同抑制乙肝病毒复制
Ling Fei,ShuangShuang Sun,Qunling Yang et al.
Ling Fei et al.
Background: In recent years, a gene-editing technology known as clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 has been developed and is progressively advancing into clinical trials. While current...
Inhibition Effects of Acetylsalicylic Acid with Nitric Oxide (NO-ASA) on Neoplastic Changes in the Exocrine Pancreas Acinar Cells of the Azaserine Injected Rats [0.03%]
乙酰水杨酸（NO-ASA）对氮芥诱导的大鼠胰腺外分泌腺泡细胞新生物变性的抑制作用研究
Serhat Doğan,Hasan Yıldız
Serhat Doğan
Background: Atypical acinar cell foci (AACF) seen in pancreatic cancer are fatal and have been studied with some causative agents. However, for the first time, the effect of acetylsalicylic acid with nitric oxide (NO-ASA)...
Clinical Application of Exhaled Breath Condensate in Diagnosis of Diseases [0.03%]
呼出气凝结液在疾病诊断中的临床应用
Zilin Zhao,Wangyang Meng
Zilin Zhao
Respiratory diseases are highly prevalent in the general population, and the morbidity, mortality, and healthcare burden on society at large have been on the rise worldwide. For example, lung cancer is a major contributor to cancer-related ...
Impact of Peroxisome Proliferator-Activated Receptor Agonists on Myosteatosis in the Context of Metabolic Dysfunction-Associated Steatotic Liver Disease [0.03%]
过氧化物酶体增殖激活受体激动剂对代谢功能障碍相关性脂肪肝病肌脂变的影响
Nathan Boliaki,Guillaume Henin,Georgia Bale et al.
Nathan Boliaki et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), and more specifically steatohepatitis may be associated with fat infiltration of skeletal muscles which is known as myosteatosis. Pan-peroxisom...
The Role of Extrahepatic Features on the Development and Management of Hepatocellular Carcinoma in Steatotic Liver Disease [0.03%]
非肝硬化性脂肪肝病中额外肝脏外因素在 hepatocellular carcinoma发生和发展中的作用
Lucia Zampaglione,Jacopo Ferrari,Naik Vietti Violi et al.
Lucia Zampaglione et al.
As the most common type of primary liver cancer, hepatocellular carcinoma (HCC) is reportedly the third leading cause of cancer-related death globally. Advanced steatotic liver disease (SLD) emerges as the most prominent contributor to HCC ...
Fabrizio Marcucci,Cristiano Rumio
Fabrizio Marcucci
Aerobic glycolysis, i.e., non-oxidative glycolysis occurring under aerobic conditions (the so-called Warburg effect) is now recognized as a hallmark of cancer. However, evidence increasingly indicates that upregulated oxidative metabolism i...
Dysregulation of Gamma Delta T-Cells, CD8+ T Cells, CD4+ T Cells, and Natural Killer Cells in Brain Pathology: Understanding HIV-Induced Impairment and Exploring Targeted GSH Therapy [0.03%]
γδT细胞、CD8+T细胞、CD4+T细胞和自然杀伤细胞在脑病理中的失调：理解HIV诱导的损伤并探索靶向型GSH疗法
John Dawi,Scarlet Affa,Yura Misakyan et al.
John Dawi et al.
This review comprehensively explores the dysregulation of Gamma Delta T-cells, CD8+ T Cells, and Natural Killer T Cells in the context of Human Immunodeficiency Virus (HIV) infection and its implications for brain pathology. It encompasses ...
Needle-Free Injection of Metformin Ameliorates Skin Photoaging Through Inhibition of Ferroptosis and Oxidative Stress [0.03%]
无针注射二甲双胍通过抑制铁死亡和氧化应激改善皮肤光老化
Jingjing Zhang,Yonghong Qin,Jin Zhang et al.
Jingjing Zhang et al.
Background: Skin photoaging is a complex process of skin aging caused by continuous exposure to ultraviolet (UV) radiation through oxidative stress and other pathways, yet effective treatments are scarce. Metformin is a d...