Analyzing Differences in Hematological and Immunological Characteristics Related to Common Gene Mutations in Myelodysplastic Syndromes [0.03%]
基于常见基因突变类型髓系肿瘤表型的血液免疫特征差异分析
Jianing Yu,Xiaohuan Peng,Rui Wang et al.
Jianing Yu et al.
Background: Genetic mutations play a crucial role in the development and progression of myelodysplastic syndromes (MDS), impacting the immune microenvironment and influencing the choice of treatment regimen, as well as th...
Identification of KIF26B as a Tumor Marker for Oral Squamous Cell Carcinoma [0.03%]
KIF26B作为口腔鳞状细胞癌肿瘤标志物的鉴定
Qibin Li,Xueling Zhan,Yongxiang Tan
Qibin Li
Background: Kinesin family member 26B (KIF26B) has been closely linked to the occurrence and progression of various tumors. However, there is limited research on its role in oral squamous cell carcinoma (OSCC). This artic...
Identification of a Diagnostic Multiomics-Based Biomarker Cluster in a Mouse Model of Pulmonary Tuberculosis [0.03%]
基于多组学的诊断生物标志物簇在肺结核小鼠模型中的鉴定
Hongtai Zhang,Mingmin Shi,Lan Yu et al.
Hongtai Zhang et al.
Background: Tuberculosis (TB) stands as the second most prevalent infectious agent-related cause of death worldwide in 2022, trailing only COVID-19. With 1.13 million reported deaths, this figure is more than half of the ...
Changing Characteristics of Treg/Th17 Cells in the Nasal Mucosa of a Mouse Model of Allergic Rhinitis and the Effect of Intervention with Anti-IL-17 Antibody [0.03%]
过敏性鼻炎小鼠模型下鼻黏膜Treg/Th17细胞动态变化及抗IL-17抗体干预效应
Haiyong Sun,Baoxu Liu,Wei Ma et al.
Haiyong Sun et al.
Background: The incidence rate of allergic rhinitis (AR) is on the rise, which seriously affects the quality of life, work efficiency, mental state of patients, and sleeping in AR sleep. This experiment aimed to investiga...
Effects of Maternal Smoke Exposure on Endoplasmic Reticulum Stress and Autophagy in the Lungs of Offspring Mice [0.03%]
母体烟雾暴露对子代小鼠肺部内质网应激及自噬的影响
Huan Chen,Jiawei Sun,Xu Xu et al.
Huan Chen et al.
Background: Cigarette smoke (CS) induces autophagy and endoplasmic reticulum (ER) stress in the lungs. Research suggests that maternal exposure to CS during pregnancy leads to decreased lung function in offspring. However...
Effects of TNF-α on Behaviour and Inflammation in Rats with Rotator Cuff Injury through NGF [0.03%]
TNF-α通过NGF对肩袖损伤大鼠行为及炎症的影响
Liang Xiang,Hailin Deng,Shuping Zhou
Liang Xiang
Objective: Rotator cuff injury is a common injury that includes inflammation, partial tearing, or complete tearing of the rotator cuff tendon. In cases of rotator cuff tears (RCTs), Tumor Necrosis Factor-alpha (TNF-α) ca...
Inhibitory Effects and Mechanisms of the Novel Shikonin Derivative DMAKO-20 on Melanoma Metastasis and Invasion [0.03%]
新型紫草素衍生物DMAKO-20抑制黑色素瘤转移侵袭的作用及机制研究
Xiaobo Zhou,Jia Huang,Shuoguo Liu et al.
Xiaobo Zhou et al.
Background: Cutaneous melanoma is a malignant tumor with an increasing incidence, prone to recurrence and metastasis. This study aims to explore the effects and mechanisms of the novel shikonin derivative 5,8-dimethyl alk...
Metallothionein III Decreases the Proliferation of Astrocytes and Enhances Pathological Improvements in a Mouse Model of Alzheimer's Disease [0.03%]
金属硫蛋白III可减少阿尔茨海默病模型小鼠星形胶质细胞增殖并促进病理改善
Jiannan Lv,Fei Wang,Tinghuan Wang et al.
Jiannan Lv et al.
Background: Alzheimer's disease (AD) affects the brain and causes difficulties with cognition and emotions. At present, there are no viable therapies to halt or slow down the advancement of AD. Metallothionein III (MT-III...
Exosome-Mediated Transfer of ALDH2 in Nasopharyngeal Carcinoma Cells Confers Increased Resistance to Paclitaxel Treatment [0.03%]
鼻咽癌细胞来源的外泌体转移ALDH2提高顺铂耐药性
Jiangyu Yan,Linrong Wu,Mengmeng Zheng et al.
Jiangyu Yan et al.
Background: Nasopharyngeal carcinoma (NPC) is an aggressive and highly metastatic malignant tumor. Despite recent therapeutic advances, resistance to Taxol (the generic name of paclitaxel) therapy remains a major challeng...
MEOX2 Participates in Hepatic Stellate Cells-Induced Liver Fibrosis by Regulating the PI3K/AKT Signaling Pathway [0.03%]
MEOX2通过调节PI3K / AKT信号通路参与肝星状细胞诱导的肝纤维化
Qiong Wang,Ting Li,Yansha He et al.
Qiong Wang et al.
Background: Hepatic stellate cells (HSCs) serve as the crucial accelerating factor in the progression of liver fibrosis (LF). In contrast to HSCs, adult-derived human liver stem/progenitor cells (ADHLSCs) exhibit greater ...