Effects of IL-6R Expression on IL-6/STAT3/HIF-1α Signaling Pathway in a Mouse Model of Parkinson's Disease with Type 2 Diabetes Co-Morbidity [0.03%]
IL-6R表达对帕金森病合并二型糖尿病小鼠模型中IL-6/STAT3/HIF-1α信号通路的影响
Aiping Hu,Yuqing She,Yang Wang et al.
Aiping Hu et al.
Background: More and more evidence has shown the process of Parkinson's disease (PD). Probably, inflammation exerts a crucial role between them. Therefore, the aim of this study was to analyze the impact of interleukin-6 ...
Chlorogenic Acid Alleviates High Glucose-induced HK-2 Cell Oxidative Damage through Activation of KEAP1/NRF2/ARE Signaling Pathway [0.03%]
氯ogenic酸通过激活KEAP1/NRF2/ARE信号通路缓解高糖诱导的HK-2细胞氧化损伤
Tian Dai,Yunfang Xiao,Hong Zhang et al.
Tian Dai et al.
Objective: To investigate the alleviating effect of chlorogenic acid (CGA) on oxidative damage in high glucose (HG)-induced HK-2 cells and to explore its potential mechanisms. ...
Ghrelin Improves Glucolipotoxicity-Induced Pancreatic β-Cellular Dysfunction and Apoptosis by Inhibiting Endoplasmic Reticulum Stress-Induced IRE1/JNK Pathway [0.03%]
胃饥饿素通过抑制内质网压力诱导的IRE1/JNK途径改善葡萄糖脂毒性诱导的胰岛β细胞功能障碍和凋亡
Xin-Ying Li,Chun-Rong Zhong,Jin-Chan Wu et al.
Xin-Ying Li et al.
Background: Glucose and fatty acid overload-induced glucolipid toxicity of pancreatic β-cells is associated with the development of diabetes. Endoplasmic reticulum stress (ERS) plays an essential role in this process. Gh...
Franziska Haumaier,Theresa Dregelies,William Sterlacci et al.
Franziska Haumaier et al.
Background: Ulcerative colitis is a well-known inflammatory bowel disease. Patients have an increased risk of developing colitis associated carcinoma (CAC). It is important for patient management to be able to distinguish...
Research Progress on Mechanisms of Modulating Gut Microbiota to Improve Symptoms of Major Depressive Disorder [0.03%]
调节肠道微生物群改善抑郁症症状的研究进展
Jixin Lin,Yan Chen,Ting Li et al.
Jixin Lin et al.
Major depressive disorder (MDD) is a clinical condition that significantly impacts patients' physical and mental well-being, quality of life, and social functioning. The pathogenesis of MDD remains unclear, but accumulating evidence suggest...
Guang Liu,Hong Zhang
Guang Liu
Lactylation plays an important regulatory role in neural development, neural stem cell fate determination, and the physiological function of the nervous system. Abnormal lactylation is closely related to the occurrence and development of hi...
A Review of Research on the Mechanism of Tumor Regulation by N-Acetyltransferase 10 [0.03%]
N-乙酰转移酶10调控肿瘤机制的研究进展及相关问题思考
Teng Cai,Yanyan Lin,Wenbo Meng
Teng Cai
N-acetyltransferase 10 (NAT10) is an important acetyltransferase that regulates telomerase activity and participates in DNA damage reactions, ribosomal RNA (rRNA) transcriptional activation, cell division, microtubule acetylation, and other...
Nanomaterial-Mediated Immunosensors and Their Performance in Detecting Tumor Markers [0.03%]
纳米材料介导的免疫传感器及其在检测肿瘤标志物中的性能
Yanping Xing,Xianli Lan,Xiyu Liu et al.
Yanping Xing et al.
The detection of tumor markers is crucial for assessing the progression of specific cancers. Numerous research studies have shown that immunosensors can convert immune-specific response biosignals into visual signals, enabling the highly se...
Proteomic Analysis of Butyrate-Resistant Colorectal Cancer-Derived Exosomes Reveals Potential Resistance to Anti-Cancer Drugs [0.03%]
丁酸耐药结直肠癌来源外泌体的蛋白质组分析揭示其潜在的抗肿瘤药物耐药性机制
Kesara Nittayaboon,Kittinun Leetanaporn,Surasak Sangkhathat et al.
Kesara Nittayaboon et al.
Background: Butyrate-resistant (BR) cells play an important role in acquiring chemoresistance in colorectal cancer (CRC). Our previous study demonstrated that BR CRC cells showed cross-resistance to chemotherapy drugs, in...
Baicalein Inhibits Metastasis of Oral Squamous Cell Carcinoma Cells by Regulating ERK/ELK-1/Snail Signaling [0.03%]
黄芩素通过调节ERK/ELK-1/Snail信号抑制口腔鳞状细胞癌的转移
Yangsheng Huang,Fang Li
Yangsheng Huang
Background: Oral squamous cell carcinoma (OSCC) is associated with high recurrence and poor prognosis. Baicalin has multiple pharmacological effects, including anti-inflammatory and anti-proliferative activities. Here, we...