Local Anesthetic Bupivacaine Inhibits Melanoma Proliferation and Metastasis by Targeting PAPSS2 [0.03%]
局部麻醉剂布比卡因通过靶向PAPSS2抑制黑色素瘤的增殖和转移
Enjian Guan,Junping Zhang,Juntao Zhou et al.
Enjian Guan et al.
Background: Melanoma is a highly invasive skin cancer with limited treatment strategies. Bupivacaine, a commonly used local anesthetic recognized for its safety, has shown promise in combating tumors. 3'-phosphoadenosine ...
Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and thus Inhibit Bladder Cancer Stem Cell Stemness [0.03%]
YAP1敲低通过减少YTHDF3稳定SMAD7从而抑制膀胱癌干细胞干性
Dandan Qiu,Lingling Gao,Xingwei Yu
Dandan Qiu
Background: The previous study has proved the oncogenic role of Yes-associated protein 1 (YAP1) in bladder cancer (BLCA), thus this study focused on its impact on bladder cancer stem cells (BCSCs) and underlying mechanism...
Genomic Alterations and Clinical Characterization in Chinese Patients with Metastatic Colorectal Cancer [0.03%]
中国转移性结直肠癌患者的基因组改变及临床特征分析
Xu-Hui Zhang,Jie-Qiong Zhou,Qing Wei et al.
Xu-Hui Zhang et al.
Background: Metastatic colorectal cancer (mCRC) is increasingly characterized by myriad genomic alterations beyond the well-known factors such as RAS, BRAF, and microsatellite instability (MSI). Novel genomic changes, inc...
Synergistic Effects of 125I Seed Implantation Brachytherapy and Gemcitabine in Pancreatic Tumors [0.03%]
125碘粒子植入与吉西他滨治疗胰腺肿瘤的协同作用研究
Qingcong Li,Yan Li,Jiayu Liu et al.
Qingcong Li et al.
Background: Monotherapy consisting of radiotherapy or chemotherapy has limited efficacy in pancreatic tumors. This study aims to investigate whether the combination of 125I brachytherapy and gemcitabine (GEM) chemotherapy...
Levosimendan Ameliorates Hypoxia-Induced Brain Injury in Rats by Modulating PTEN/Akt Signaling Pathway-Mediated Ferroptosis [0.03%]
左西孟丹通过调节PTEN/AKT信号通路介导的铁死亡改善大鼠缺氧诱导的脑损伤
Wei Meng,Chang Shu,Hong Gao
Wei Meng
Background: Levosimendan (Levo) is a drug commonly used to treat heart failure. Recent studies have suggested that Levo may have neuroprotective effects, but it is still unknown how exactly it contributes to hypoxia-induc...
Gastrodin Ameliorates the Inflammation, Oxidative Stress, and Extracellular Matrix Degradation of IL-1β-Mediated Fibroblast-Like Synoviocytes via Suppressing the Gremlin-1/NF-κB Pathway [0.03%]
姜黄素通过抑制GHRELIN-1/NF-κB通路改善IL-1β介导的类风湿性关节炎滑膜成纤维细胞的炎症、氧化应激和细胞外基质降解
Yong Hu,Ming Li,Xiao-Yan Chen et al.
Yong Hu et al.
Background: Synovial inflammation plays a crucial role in osteoarthritis (OA). Gastrodin (GAS), an active ingredient derived from the Gastrodia elata Blume rhizome, possesses antioxidant and anti-inflammatory pharmacologi...
SIRT6 Inhibits the Proliferation and Collagen Synthesis of Keloid Fibroblasts through MAPK/ERK Pathway [0.03%]
SIRT6通过MAPK / ERK途径抑制瘢痕疙瘩成纤维细胞的增殖和胶原合成
Tao Zhou,Yajie Chen,Chao Wang et al.
Tao Zhou et al.
Background: Keloid, a fibroproliferative disorder, significantly impacts patients' quality of life, yet effective therapies remain elusive. This study explored the role of silent information regulator 6 (SIRT6) in modulat...
The Role of Intra-Articular Delivery of BM-MSCs-Derived Exosomes in Improving Osteoarthritis: Implication of circYAP1/ miRNA-21/ TLR7 Axis [0.03%]
骨髓间充质干细胞衍生的外泌体在关节内递送对改善骨关节炎的作用：circYAP1/miRNA-21/Toll样受体7轴的意义
Shimaa Saad El-Din,Basma Emad Aboulhoda,Amira Hassouna et al.
Shimaa Saad El-Din et al.
Background: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have recently attracted great attention due to their crucial anti-inflammatory and regenerative properties. This work aims to examine the curative impact of...
Saikosaponin A Ameliorates Metabolic Inflammation and Intestinal Barrier Damage in DIO Mice through the Nrf2/ARE Pathway [0.03%]
补骨脂香豆素通过Nrf2/ARE信号通路改善DIO小鼠代谢性炎症和肠屏障损伤
Daoxu Huang,Zengpai Zheng,Yiling Huang et al.
Daoxu Huang et al.
Background: Obesity is linked to impaired intestinal barrier function and inflammation. Saikosaponin A (SSA), a triterpene saponin from Bupleurum chinense, has shown beneficial effects on intestinal colitis in mice. Howev...
Injection of Collagen Binding Domain-Brain Derived Neurotrophic Factor Promotes SIRT1 Expression: Improving Neuroinflammation in Experimental Subarachnoid Hemorrhage [0.03%]
胶原结合域脑源性神经营养因子注射促进SIRT1表达：改善实验性蛛网膜下腔出血的神经炎症
Xiaosheng Lv,Yuwen Song,Yanyan Shi et al.
Xiaosheng Lv et al.
Background: Subarachnoid hemorrhage (SAH) is a severe cerebrovascular disease, often leading to neuroinflammation and neuronal damage. Activation of the Nucleotide-binding oligomerization domain (NOD)-like receptor protei...