Tumor Suppressor LINC02487 Inhibits the Progression of Cervical Cancer in Vitro by Regulating the PTEN/Akt/mTOR Pathway [0.03%]
肿瘤抑制因子LINC02487通过调节PTEN/Akt/mTOR途径抑制宫颈癌的进展
Ru Sun,Su-Li He,Hai-Yan Liu et al.
Ru Sun et al.
Objective: Cervical cancer (CC) ranks among the most prevalent malignant tumors affecting the female reproductive system. Nonetheless, various shortcomings exist within current treatment approaches for CC. Therefore, the ...
Simvastatin Inhibits the Formation of NETs by the Mac-1 Pathway to Reduce Hepatic Ischemia-Reperfusion Injury under High-Fat Conditions [0.03%]
辛伐他汀通过Mac-1途径抑制NETs的形成以减轻高脂状态下肝脏缺血再灌注损伤
Shikai Wang,Zhipeng Li,Yunxiang Chang et al.
Shikai Wang et al.
Background: Hyperlipidemia is one of the main causes of aggravated hepatic ischemia-reperfusion injury (IRI). Simvastatin (SIM), a lipid-lowering drug, has been shown to effectively alleviate IRI caused by hyperlipidemia....
Yingfeng Zhang,Kang Wang,Jiuping Li
Yingfeng Zhang
Background: Bile duct injury (BDI) is a severe complication following cholecystectomy and is therefore a particularly concerning surgical predicament for hepatobiliary surgeons. Owing to very high medical compensation awa...
Pediatric Life Support in Prehospital Emergency Medicine: An Empirical Investigation in the Context of Taiwan's Critical Shortage of Pediatric Emergency Specialists [0.03%]
台湾儿科急诊专科医师严重不足情况下院前急救生命支持实证研究——以儿童为主病人之实地研究计划
Wen-Fan Chen,Yung-Kuan Chan,Wei-Hsi Chang et al.
Wen-Fan Chen et al.
Background: This study aims to facilitate parental identification of designated emergency facilities for expeditious pediatric care within the framework of Taiwan's newly implemented "regional joint defense" approach to p...
Hypoxia-Induced Ephrin-B2 Facilitates Proliferation and Induces Glycolytic Metabolism in Cutaneous Squamous Cell Carcinoma by Modulating PKM2/HIF-1α Axis [0.03%]
缺氧诱导的Ephrin-B2通过调节PKM2/HIF-1α轴促进皮肤鳞状细胞癌增殖和糖酵解代谢
Xiaoqing Wang,Zheng Zhang,Guanglei Hu et al.
Xiaoqing Wang et al.
Background: Cutaneous squamous cell carcinoma (cSCC) is a fatal disease characterized by metabolic dysregulation. The role of ephrin type-B receptor 2 (ephrin-B2), a crucial molecule in cancer cell biology, in regulating ...
Targeting STIM1 Contributes to Alleviating Remodeling of Vascular Smooth Muscle Cells in Atherosclerosis [0.03%]
靶向STIM1有助于缓解动脉粥样硬化血管平滑肌细胞的重塑
Zhenyu Cui,Yue Zhang,Lezhi Sheng
Zhenyu Cui
Background: Remodeling of vascular smooth muscle cells (VSMCs), as a pathological hallmark of cardiovascular diseases, is related to the molecular rewiring of Calcium signaling, which induces upregulation of stromal inter...
Clinical Analysis of Abnormal Brainstem Auditory Evoked Potential in Neonates with Hyperbilirubinemia [0.03%]
高胆红素血症新生儿脑干听觉诱发电位异常的临床分析
Jufen Xu,Dandan Shu,Qin Li et al.
Jufen Xu et al.
Background: Severe neonatal hyperbilirubinemia can cause hearing impairment. Bilirubin can be deposited in nerve cells, and the brainstem and the 8th nerve are especially sensitive to bilirubin toxicity. Abnormal changes ...
PAR1 Activation, via LMBR1/BMP Axis, Promotes the Osteogenesis of Periodontal Ligament Stem Cells (PDLSCs) and Alleviates the Inhibitory Effect of Sodium Butyrate on PDLSCs Osteogenesis [0.03%]
PAR1通过LMBR1/BMP轴促进牙周膜干细胞成骨分化并缓解丁酸钠对PDLSCs成骨分化的抑制作用
Lin Xia,Ziliang Yang,Chao Hu
Lin Xia
Background: Periodontitis is the leading cause of tooth loss and can exacerbate various systemic inflammatory conditions. Periodontal ligament stem cells (PDLSCs) stand out as prominent and favorable candidates for promot...
Baicalin Plays an Anti-Osteosarcoma Role in Vitro and Promotes Osteogenic Differentiation by Inhibiting NF-κB Signaling [0.03%]
黄芩素通过抑制NF-κB信号通路发挥体外抗骨肉瘤和促进成骨分化作用
Zhi-Fei Zhao,Xue-Fei Cheng,Meng Yu et al.
Zhi-Fei Zhao et al.
Background: Osteosarcoma (OS) is commonly recognized as a malignant cancer originating from bone-forming mesenchymal stem cells, comprising approximately 20% of sarcomas. Baicalin, a bioactive flavonoid glycoside isolated...
Anti-Inflammatory Immunomodulatory Activity of Valacyclovir on the in Vitro Activated Mammalian Macrophages [0.03%]
缬更昔洛韦的免疫调节作用抑制哺乳动物巨噬细胞体外活化引起的炎症反应
Esra Aydemir
Esra Aydemir
Background: Aciclovir, often known as acyclovir, is a nucleoside analog that exhibits antiviral activity in vitro against human herpesvirus 6 (HHV-6), cytomegalovirus (CMV), varicella-zoster virus (VZV), and herpes simple...