Curcumin Alleviates Airway Inflammation in Cough-Variant Asthmatic Rats by Modulating M1/M2 Macrophage Polarization [0.03%]
姜黄素通过调节M1/M2型巨噬细胞极化缓解变应性咳嗽变异型哮喘小鼠的气道炎症反应
Hui Yang,Jing Xie,Mengqing Wang et al.
Hui Yang et al.
Background: With the increase of environmental pollution and atypical pathogen infections, the incidence of cough variant asthma (CVA) has been increasing annually, making it a pressing issue of the medical community. Thi...
SIRT2 Alleviates Inflammatory Response, Apoptosis, and ECM Degradation in Osteoarthritic Chondrocytes by Stabilizing PCK1 [0.03%]
SIRT2通过稳定PCK1缓解骨关节炎软骨细胞的炎症反应、凋亡和ECM降解
Fan Zhong,Shiqiang Cen,Cheng Long et al.
Fan Zhong et al.
Background: It has been reported that Sirtuin 2 (SIRT2) prevents phosphoenolpyruvate carboxykinase 1 (PCK1) degradation, which can be involved in aging-induced osteoarthritis (OA), but the molecular mechanism of SIRT2/PCK...
The Evaluation of Gastric Cancer Lymphovascular Invasion Using CT Volume Perfusion [0.03%]
基于CT灌注的胃癌淋巴血管侵犯评估的价值探讨
Yueyue Li,Liebin Huang,Lin Li et al.
Yueyue Li et al.
Background: The best treatment option for patients with resectable gastric cancer is radical gastric cancer surgery. However, the postoperative overall survival rate is low. Lymphovascular invasion (LVI) is a risk factor ...
BML-111 Modulates and Alleviates p38/MAPK Signaling Pathway and Th1/Th2/Th17 Cytokine Response in Murine Psoriasis-Like Dermatitis [0.03%]
BML-111调控并缓解小鼠银屑病样皮炎的p38/MAPK信号途径和Th1/Th2/Th17细胞因子反应
Yuepeng An,Qiong Zhang,Yukun Ren et al.
Yuepeng An et al.
Background: Psoriasis is a prevalent cutaneous inflammatory disorder characterized by elevated keratinocyte inflammation. 5(S)-6(R)-7-trihydroxyheptanoic-acid-methyl-ester (BML-111), an established analogue of lipoxin A4,...
Establishment of a Disease Model Using Patient-Specific Induced Pluripotent Stem Cells-Derived Trabecular Meshwork Cells in a Chinese Primary Open-Angle Glaucoma Mega-Pedigree [0.03%]
在中国原发性开角型青光眼家系中，利用患者特定诱导多能干细胞来源的小梁细胞建立疾病模型
Huifeng Rong,Ziming Luo,Mingjun Tang et al.
Huifeng Rong et al.
Background: Primary open-angle glaucoma (POAG) is one of the most common insidious blinding eye diseases. Understanding the pathogenic mechanisms of it is extremely important. It is accepted that POAG attacks specific ocu...
Focal Adhesion Kinase (FAK) and c-Src Dependent Signal Transduction in Cell Adhesion [0.03%]
粘附斑激酶(FAK)和c-Src依赖的细胞粘连信号转导机制研究进展
Kazuo Katoh
Kazuo Katoh
This review predominantly acquaints the role of focal adhesion kinase (FAK) and cellular-Src (c-Src) in cell adhesion. Cell adhesion is a crucial phenomenon that causes the cells to interact with the extracellular matrix (ECM) or with each ...
Lindokuhle Hadebe,Nicolette N Houreld
Lindokuhle Hadebe
Diabetes mellitus (DM) and its associated complications, including diabetic kidney disease, neuropathy, and retinopathy, impose significant challenges on healthcare systems due to their high morbidity, mortality, and associated costs. Exist...
Hamza Islam,Syed Muhammad Hassaan,Rabia Islam et al.
Hamza Islam et al.
This article explores the correlation between vitamin D levels and cardiovascular health, focusing on hypertension, atherosclerosis, and cardiac dysfunction. Cardiovascular diseases (CVDs) rank as the leading global cause of death, undersco...
Gut-Liver Axis: Modulating the Gut Microbiota and Its Metabolic Products as a Potential Therapeutic Strategy for the Treatment of Hepatic Ischemia-Reperfusion Injury [0.03%]
肝脏缺血再灌注损伤治疗中调节肠道菌群及其代谢产物的潜在策略：肝肠轴的作用
Jiahao Wang,Yali Yun,Xunan Dong et al.
Jiahao Wang et al.
Hepatic ischemia-reperfusion injury (HIRI) is a major complication reported in various clinical scenarios such as liver transplantation (LTx), hepatectomy, and acute hepatic insult. This condition affects the restoration of hepatic function...
The Pathophysiology, Diagnosis and Management of Chronic Inflammatory Skin Diseases [0.03%]
慢性炎症性皮肤病的病生理、诊断和治疗
Liliana Z Tong,Rini M Desai,Rebecca Olsen et al.
Liliana Z Tong et al.
Atopic dermatitis, psoriasis, rosacea, seborrheic dermatitis, allergic contact dermatitis, and irritant contact dermatitis comprise a large proportion of chronic inflammatory dermatoses. This paper reviews the clinical presentations, pathop...