Angiotensin-converting Enzyme 2 Suppresses Pulmonary Fibrosis Associated with Wnt and TGF-β1 Signaling Pathways [0.03%]
血管紧张素转换酶2通过Wnt和TGF-β1信号通路抑制肺纤维化
Yanhua Tang,Ju Liu,Ling Liu
Yanhua Tang
Background: Pulmonary fibrosis is a severe respiratory condition marked by the formation of scar tissue in the lungs, which makes it distinguishable from atypical fibrosis. The specific mechanisms of angiotensin-convertin...
BRIP1 Induced Ferroptosis to Inhibit Glioma Cells and was Associated with Increased Oxidative Stress [0.03%]
BRIP1通过增加氧化应激诱导铁死亡从而抑制胶质瘤细胞生长
Cheng Chen,Zhong-Hua Wu,Xiao-Jian Lu et al.
Cheng Chen et al.
Background: Glioma, a malignant brain tumour, poses a significant threat to human life and well-being. Identifying new treatment targets is crucial. This study aimed to explore the impact of BRIP1 (BRCA1 interacting helic...
Clinical Risk Factors and Characteristics of Coronary Artery Lesions in Premature Acute Myocardial Infarction Patients [0.03%]
早发急性心肌梗死患者的临床危险因素及冠脉病变特点分析
Rong Wang,Shiqin Tu,Mingzhuo Tan et al.
Rong Wang et al.
Background: The incidence of atherosclerotic cardiovascular disease (ASCVD) is increasing, with individuals experiencing acute myocardial infarction (AMI) at a younger age. Premature AMI is a serious condition with high r...
Bipolar Disorder and Ubiquitin Proteasome System Dysfunction: Peripheral Blood Levels of Molecules Playing a Role in Ubiquitination and Their Relationship to Sleep Quality [0.03%]
分裂情感障碍与泛素-蛋白酶体系统功能障碍：参与泛素化的分子的外周血水平及其与睡眠质量的关系
Ünsal Aydιnoğlu,Ece Yazla,İhsan Çetin et al.
Ünsal Aydιnoğlu et al.
Background: Bipolar disorder (BD) is a serious mood disorder, notable for its morbidity and prevalence. It ranks among the top 10 diseases globally in terms of functional impairment among affected individuals. Studies inv...
Propofol Triggers Cell Death in Lung Cancer Cells by Increasing PANX1 Expression, Activating the Mitochondrial Cell Death Pathway, and Enhancing ROS Levels [0.03%]
异丙酚通过增加PANX1表达、激活线粒体细胞死亡通路和增强ROS水平在肺癌细胞中诱导细胞死亡
Jie Zhang,Anqing Chen,Yonggang Song
Jie Zhang
Background: Lung cancer treatment remains a global challenge due to tumor cell resistance. Propofol, traditionally used as an anesthetic, has demonstrated potential anti-tumor properties. This study seeks to elucidate how...
Allele C of rs6068816 in the CYP24A1 Gene is Associated with Increased Risk of Hyperuricemia in the Chinese Population: A Case-Control Study [0.03%]
CYP24A1基因rs6068816位点C等位基因与中国人群中高尿酸血症易感性的关联：一项病例对照研究
Jiahong Shangguan,Wenjing Zhang,Xiaodan Zhu et al.
Jiahong Shangguan et al.
Background: Vitamin D (1,25-(OH)2D) has been reported to be associated with hyperuricemia in many epidemiologic reports. CYP24A1 is a rate-limiting enzyme involved in vitamin D metabolism. The aim of this study was to inv...
Role of Endoplasmic Reticulum Stress in Melatonin-induced Apoptosis and Inhibition of Invasion and Migration in Adrenocortical Carcinoma Cells [0.03%]
褪黑素通过内质网应激诱导肾上腺皮质癌细胞凋亡及抑制侵袭和迁移的作用研究
Qingsun Lai,Sheng Su,Peichun He et al.
Qingsun Lai et al.
Background: Melatonin, a hormone synthesized by the pineal gland and released into the blood, seems to have anti-tumor properties. However, the mechanisms of the anti-cancer effect of melatonin are largely unknown. This s...
Irisin Treatment Prevents Isoproterenol-Induced Cardiac Fibrosis in Mice [0.03%]
irisin治疗可预防异丙肾上腺素诱导的小鼠心脏纤维化
Clelia Suriano,Roberta Zerlotin,Patrizia Pignataro et al.
Clelia Suriano et al.
Background: Cardiac fibrosis is a pathophysiological process that occurs as the end stage of cardiovascular diseases. Irisin is a myokine secreted mainly by skeletal muscle exerting pleiotropic effects. Previous studies f...
Regulation of Ankyrin-G on Nav1.5 Channel in Hypoxic HL-1 Cardiac Muscle Cells [0.03%]
缺氧对心肌细胞ANKG结合调控Nav1.5通道的影响机制研究
Shanshan Ma,Shuqin Yang,Peng Xu et al.
Shanshan Ma et al.
Background: Hypoxia has a major regulatory impact on the electrical activity transmission in the myocardium, and it is involved in the development of tachyarrhythmia disease. Anchor protein G (ankyrin-G, ANK-G) is associa...
Subcutaneous BNP Injections in Rabbits: A Novel Approach to Mitigate Myocardial Remodeling in Atrial Fibrillation [0.03%]
兔皮下注射BNP抑制心房颤动心脏重构的可行性研究
Si Zhong,Rui He,Jia Yu et al.
Si Zhong et al.
Background: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with increased morbidity and mortality, highlighting the need for novel therapeutic strategies. This study aimed to evaluate the effects of...