Adam E Snook,Scott A Waldman
Adam E Snook
Our immune system is characterized by remarkable specificity, potency, and memory -- the ability of a single vaccine treatment to provide life-long protection. No pharmacologic treatment for any indication can provide the same level of safe...
Review
Discovery medicine. 2013 Feb;15(81):120-5. DOI: 2013
Sahana Nagabhushan Kalburgi,Nadia N Khan,Steven J Gray
Sahana Nagabhushan Kalburgi
The past few years have seen rapid advancements in vector-mediated gene transfer to the nervous system and modest successes in human gene therapy trials. The purpose of this review is to describe commonly-used viral gene transfer vectors an...
Review
Discovery medicine. 2013 Feb;15(81):111-9. DOI: 2013
Donald D Rao,Zhaohui Wang,Neil Senzer et al.
Donald D Rao et al.
Despite billions of dollars allocated to cancer research, cancer remains the number 2 cause of death in the United States with less than 50% of advanced cancer patients living one year following standard treatment. Cancer is a complex disea...
Review
Discovery medicine. 2013 Feb;15(81):101-10. DOI: 2013
Current concepts in diagnosing and managing primary vitreoretinal (intraocular) lymphoma [0.03%]
原发性玻璃体视网膜淋巴瘤的诊断与治疗进展
Chi-Chao Chan,H Nida Sen
Chi-Chao Chan
Primary vitreoretinal lymphoma (PVRL), previously called primary intraocular lymphoma (PIOL), is a rare and fatal ocular malignancy. PVRL is a subset of primary central nervous system lymphoma (PCNSL), mostly a diffuse large B-cell lymphoma...
Review
Discovery medicine. 2013 Feb;15(81):93-100. DOI: 2013
Autoimmunity, end organ damage, and the origin of autoantibodies and autoreactive T cells in systemic lupus erythematosus [0.03%]
自身免疫、靶器官损伤以及系统性红斑狼疮中自身抗体和自身反应性T细胞的起源
Janet E Lewis,Shu Man Fu,Felicia Gaskin
Janet E Lewis
Systemic lupus erythematosus (SLE) is a prototype of systemic autoimmunity affecting many systems. Both antibodies and autoreactive T cells play significant roles in its pathogenesis. Experimental data and clinical observations indicate tha...
Review
Discovery medicine. 2013 Feb;15(81):85-92. DOI: 2013
Javier Conde,Morena Scotece,Verónica López et al.
Javier Conde et al.
A large body of evidence from clinical and experimental studies is aiding to understand the close relationships between obesity and rheumatic diseases. For instance, it is generally accepted that obesity contributes to the development of os...
Review
Discovery medicine. 2013 Feb;15(81):73-83. DOI: 2013
Christopher M Tolleson,John Y Fang
Christopher M Tolleson
Parkinson's disease is the second most common neurodegenerative disorder. Despite fairly typical clinical and pathologic features, the etiology remains unknown. Many cellular mechanisms such as oxidative stress, mitochondrial dysfunction, l...
Review
Discovery medicine. 2013 Jan;15(80):61-6. DOI: 2013
Relevance of the type I interferon signature in multiple sclerosis towards a personalized medicine approach for interferon-beta therapy [0.03%]
I型干扰素在多发性硬化症中的信号特征向干扰素β治疗的个性化医学方法的相关性研究
Cornelis L Verweij,Saskia Vosslamber
Cornelis L Verweij
Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system. The disease is characterized by progressive neurological dysfunction due to demyelination of the nerves, which leads to disability. Currently, no...
Review
Discovery medicine. 2013 Jan;15(80):51-60. DOI: 2013
Genetics and genetic testing of dilated cardiomyopathy: a new perspective [0.03%]
扩张型心肌病的遗传学和基因检测：新视角
Luisa Mestroni,Matthew R G Taylor
Luisa Mestroni
The completion of the Human Genome Project was a landmark achievement, but as clinical genetic testing becomes more mainstream, the extent of remarkable genetic variation is increasingly being appreciated. Newer DNA sequencing technology ca...
Review
Discovery medicine. 2013 Jan;15(80):43-9. DOI: 2013
Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 2: new immune paradigm [0.03%]
棘手的阿尔茨海默病：免疫标志物能帮助我们更好地认识该疾病吗？第二部分：新的免疫学范式
Tamas Fulop,Guy Lacombe,Stephen Cunnane et al.
Tamas Fulop et al.
Alzheimer's disease (AD) is the most common form of dementia. Its most important pathological hallmarks are profound neuronal loss, presence of intracellular neurofibrillary tangles, and extracellular deposition of beta-amyloid protein (Aβ...
Review
Discovery medicine. 2013 Jan;15(80):33-42. DOI: 2013