Analysis of Risk Factors Associated with Organic Erectile Dysfunction in Patients with Type 2 Diabetes Mellitus and Erectile Dysfunction [0.03%]
2型糖尿病合并勃起功能障碍患者有机性勃起功能障碍危险因素分析
Mingming Lu,Dawei Ni,Wei Wu et al.
Mingming Lu et al.
Background: Diabetes mellitus is a common metabolic disorder, and diabetic erectile dysfunction (DMED) is one of its common complications. The differentiation of the types of erectile dysfunction (ED) is fundamental to tr...
Carbamazepine Inhibits Lung Cancer Metastasis by Suppressing Chemokine Receptor 4 Expression [0.03%]
卡马西平通过抑制化学因子受体4表达抑制肺癌转移
Chenyu Zhang,Xiaofen Ma,Zhiwei Lv et al.
Chenyu Zhang et al.
Background: Lung cancer is one of the leading causes of cancer-related deaths worldwide, with treatment failure resulting from metastasis. C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in tumor cell migrati...
Knocking Down WARS1 in Colorectal Cancer: Implications for Apoptosis and Cell Cycle Arrest via the p53 Signaling Pathway [0.03%]
结直肠癌中的WARS1敲除：通过p53信号通路诱导凋亡和细胞周期阻滞的含义
Ming Hu,Hairui Zhou,Xinna Du et al.
Ming Hu et al.
Background: Preventing the progression and recurrence of colorectal cancer (CRC) remains a clinical challenge due to its heterogeneity and drug resistance. This underscores the need to discover new targets and elucidate t...
Repeated Amphetamine Exposure Blunted Angiotensin II-Induced Responses Mediated by AT1 Receptors [0.03%]
反复安非他命暴露可使血管紧张素II型受体介导的缩血管反应降低
Brenda Solange Casarsa,Victoria Belén Occhieppo,María Josefina Piermarini et al.
Brenda Solange Casarsa et al.
Background: Angiotensin II, is critical in regulating the sympathetic and neuroendocrine systems through angiotensin II type 1 receptors (AT1-R). Angiotensin II intracerebral administration increases water and sodium inta...
LncRNA ZNF667-AS1: A Promising Therapeutic Target for Colorectal Cancer by Regulating PNRC2-Mediated Cell Proliferation, Invasion and Apoptosis [0.03%]
长链非编码RNA ZNF667-AS1通过调节PNRC2介导的细胞增殖、侵袭和凋亡，成为治疗结直肠癌的潜在靶点
Haiqiang Li,Xuning Shen,Yan Li
Haiqiang Li
Background: Long non-coding RNA (lncRNA) zinc finger protein 667-antisense RNA 1 (ZNF667-AS1) is closely related to the advancement of a variety of cancers, but its functional role in colorectal cancer remains unclear. Th...
Construction of a Multi-View Deep Learning Model for the Severity Classification of Acute Pancreatitis [0.03%]
急性胰腺炎严重程度分级的多视图深度学习模型研究
Kailai Xiang,Dong Shang
Kailai Xiang
Background: Acute pancreatitis (AP) is a prevalent pathological condition of abdomen characterized by sudden onset, high incidence and complex progression. Timely assessment of AP severity is crucial for informing interve...
Regulation of Concanavalin A-induced Immune Hepatitis in Mice by Dihydromyricetin at the M1/M2 Type Macrophage Level [0.03%]
黄酮二氢杨梅素通过M1/M2型巨噬细胞对刀豆蛋白A诱导的小鼠免疫性肝炎的调节作用研究
Xinpeng Zhang,Yan Liu,Kaijin Yang et al.
Xinpeng Zhang et al.
Background: Autoimmune hepatitis (AIH) is an autoimmune disease accompanied by an autoimmune inflammatory response that often leads to severe liver damage. In addition, it may further lead to complications such as liver f...
Clinical Application of a Big Data Machine Learning Analysis Model for Osteoporotic Fracture Risk Assessment Built on Multicenter Clinical Data in Qingdao City [0.03%]
基于青岛市多中心临床数据的骨质疏松性骨折风险评估大数据机器学习分析模型的临床应用研究
Bing Li,Yanru Yang,Feng Shen et al.
Bing Li et al.
Background: Osteoporotic fractures (OPF) pose a public health issue, imposing significant burdens on families and societies worldwide. Currently, there is a lack of comprehensive and validated risk assessment models for O...
Multicenter Study
Discovery medicine. 2025 Jan;37(192):55-63. DOI:10.24976/Discov.Med.202537192.5 2025
Mechanism of Corylin Inhibiting the Development of Osteosarcoma: Regulating HMGB1/p38 MAPK Signaling [0.03%]
锦灯笼苷抑制骨肉瘤发展的机制研究：通过调节HMGB1/p38MAPK信号通路
Rongyao Yan,Hao Wang,Zhenyu Cai et al.
Rongyao Yan et al.
Background: High-mobility group box 1 (HMGB1) participates in the progression of osteosarcoma (OS) through the p38 mitogen-activated protein kinase (MAPK) signaling pathway. Corylin, one of the active components of Psoral...
Marco Tatullo,Gianfranco Favia,Nicola Antonio Adolfo Quaranta et al.
Marco Tatullo et al.
Salivary gland dysfunctions are common conditions variously related to aging, inflammatory players, and any other factor able to alter their normal physiology. These conditions may significantly impact oral and systemic health, affecting th...