The Urgent Need to Assess and Prevent the Deposits of Microplastics and Nanoplastics in Our Brain [0.03%]
重新评估和预防微塑料及纳米塑料在大脑中沉积的紧迫性
Mario Manto,Jerome R Lechien
Mario Manto
Bridging the Translational Gap: Prioritizing the Spontaneous Canine Osteoarthritis Model for Preclinical Studies [0.03%]
缩短转化差距：优先选择自发性犬骨关节炎模型进行临床前研究
Khan Sharun,Shajahan Amitha Banu,Luca Melotti
Khan Sharun
Computed Tomography Imaging for the Diagnosis of Primary Sarcomatoid Carcinoma of the Lung: A Case Report [0.03%]
计算机断层扫描在原发性肺肉瘤样癌诊断中的应用-一例报告
Li-Feng Xu,Xi-Sheng Zhou,Feng Chen et al.
Li-Feng Xu et al.
Aim: Primary sarcomatoid carcinoma (PSC) of the lung is a rare malignant neoplasm characterized by the presence of both carcinomatous and sarcomatoid components, typically presenting as a solitary pulmonary mass. Imaging ...
S100A8 Mediates Autophagy and Apoptosis in Ovarian Cancer Cells via the PI3K/Akt Pathway [0.03%]
S100A8通过PI3K/Akt途径介导卵巢癌细胞的自噬和凋亡
Xiaojie Ma,Yu Wu,Guanyu Cao
Xiaojie Ma
Background: Ovarian cancer (OC) is one of the most lethal forms of gynecological malignancies. Previous studies indicate that S100 calcium-binding protein A8 (S100A8) regulation of the phosphoinositide 3-kinase/protein ki...
Inhibiting NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis: A New Role of GADD45B's Role in Hypertriglyceridemia-Induced Acute Pancreatitis [0.03%]
GADD45B通过抑制NLRP3/Caspase-1/GSDMD介导的焦亡在高甘油三酯血症急性胰腺炎中的新作用
Shengang Zhou,Yingge Xu,Jianfeng Tu et al.
Shengang Zhou et al.
Background: Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is a severe form of pancreatitis, rapidly progressing to multiorgan failure. Growth arrest and DNA damage-inducible beta (GADD45B) play a crucial role i...
Amygdalin Alleviates Airway Inflammation and Remodeling in Asthma Mice: Involvement of TGF-β1/Smads Signaling Pathway [0.03%]
苦杏仁苷通过TGF-β1/Smads信号通路改善小鼠哮喘炎症及重塑作用研究
Jing Zhao,Yamei Wang,Haixu Wang
Jing Zhao
Background: Asthma is a common respiratory system disease characterized by airway inflammation and airway remodeling. Amygdalin, an active component of the traditional Chinese medicine Bitter Almonds, has been shown to in...
Combined Oral Contraceptives Modulate Apoptosis via IL-11/PI3K/AKT Pathway in Rat With Premature Ovarian Insufficiency [0.03%]
复方口服避孕药通过IL-11/PI3K/AKT途径调节早发性卵巢功能不全大鼠卵泡凋亡
Meiling Chen,Fan Zhang,Fang You et al.
Meiling Chen et al.
Background: Premature ovarian insufficiency (POI) is characterized by a reduction in primary follicle count along with abnormal follicle development. This study aims to explore the impact of combined oral contraceptives (...
Improved Sampling Method to Enhance the Positive Rate of HER2 Detection in Gastric Cancer [0.03%]
一种改进的采样方法以提高胃癌HER2检测阳性率
Huan Shi,Li-Qing Liu,Yue-Hong Qin et al.
Huan Shi et al.
Background: To analyze the efficacy of the improved sampling method in enhancing the accuracy of Human Epidermal Growth Factor Receptor 2 (HER2) detection within gastric cancer surgical specimens, in order to decrease the...
Protective Role of Quercetin in Chronic Atrophic Gastritis: Modulation of Gastric Mucosal Integrity via the Transforming Growth Factor-beta1/Smads Signaling Pathway [0.03%]
檞皮素对慢性萎缩性胃炎保护作用及通过转化生长因子-β1/smad信号途径调控胃黏膜完整性的机制研究
Peipei Cai,Qingqing Song,Fangpeng Ye et al.
Peipei Cai et al.
Objective: This study aimed to elucidate the protective effects of quercetin (Que) on the gastric mucosa in a rat model of chronic atrophic gastritis (CAG), with emphasis on the regulation of the transforming growth facto...
Hypoxia-Induced Up-Regulation of ACSS2 Drives the PI3K/AKT/mTOR Pathway Through HMGCS1 to Enhance the Proliferation and Stemness of Pancreatic Cancer Cells [0.03%]
缺氧通过HMGCS1上调ACSS2驱动PI3K/AKT/mTOR途径以增强胰腺癌细胞的增殖和干细胞特性
Zhangcheng Zhao,Gengyu Li,Beibei Zhang et al.
Zhangcheng Zhao et al.
Objective: Pancreatic cancer (PC) is a type of highly malignant tumor associated with poor prognosis, whose progression is driven by hypoxia in the tumor microenvironment. This study aims to explore the effects of hypoxia...