Predictive value of liver fibrosis markers and model for end-stage liver disease score in evaluating the degree of esophageal and gastric varices in cirrhosis [0.03%]
肝纤维化标志物和终末期肝病模型评分评估肝硬化食管胃静脉曲张程度的预测价值分析
Linan Liu,Yufei Chang,Hui Wang
Linan Liu
Objective: We aimed to investigate the predictive value of liver fibrosis (LF) markers and the Model for End-Stage Liver Disease (MELD) score in assessing the severity of esophageal and gastric varices (EGV) in patients w...
Gypenosides attenuate H2O2-induced oxidative stress in orbital fibroblasts from thyroid-associated ophthalmopathy by activating the Nrf2/ERK/HO-1 signaling pathway [0.03%]
甘草次酸通过激活Nrf2/ERK/HO-1信号通路缓解甲状腺相关性眼病轨道成纤维细胞内氧化应激损伤
Chao Ma,Kaijun Li,Haoyu Li et al.
Chao Ma et al.
Objectives: To explore the antioxidative effects of gypenosides (Gyps) in orbital fibroblasts (OFs) derived from patients with thyroid-associated ophthalmopathy (TAO) and to validate their therapeutic efficacy in vivo usi...
Banxia Xiexin Decoction inhibits chemoresistance in gastric cancer by regulating BMSC-derived exosome-mediated G3BP1-YWHAZ protein interaction [0.03%]
半夏泻心汤通过调节骨髓间充质干细胞源性外泌体介导的G3BP1-YWHAZ蛋白相互作用抑制胃癌化疗耐药性
Fan Yang,Senyu Liu,Zhongbo Zhu et al.
Fan Yang et al.
Objective: To investigate whether Banxia Xiexin Decoction (BXD) reverses bone marrow mesenchymal stem cell (BMSC)-derived exosome-induced oxaliplatin resistance in gastric cancer (GC) and to elucidate the underlying mecha...
Impact of SGLT-2 inhibitors on long-term prognosis in patients with heart failure with preserved ejection fraction: a systematic review and meta-analysis of randomized controlled trials [0.03%]
钠-葡萄糖协同转运蛋白2抑制剂对射血分数保留心力衰竭长期预后影响的系统评价和meta分析
Peijian Shi,Tanqi Chen
Peijian Shi
Objectives: This study aimed to assess the effect of Sodium-Glucose Cotransporter-2 (SGLT-2) inhibitor (SGLT-2i) on long-term (≥1 year) mortality, heart failure (HF)-related hospital admissions, and safety in patients su...
Study on the protective effects and molecular mechanisms of L-sodium lactate in mouse colitis [0.03%]
L-乳酸钠对鼠结肠炎保护作用及机制的实验研究
Pan Huang,Kang-Ping Shao,Si-Yu Wang et al.
Pan Huang et al.
The present study investigates the therapeutic potential of L-sodium lactate in a dextran sodium sulfate (DSS)-induced colitis C57BL/6J mice model. Treatment with L-sodium lactate significantly mitigated disease severity, as evidenced by re...
Metabolic reprogramming-associated genomic instability drives colorectal cancer progression via the UBXN1-NF-κB axis [0.03%]
代谢重组引起的基因组不稳定通过UBXN1-NF-κB轴驱动结直肠癌进展
Long Qian,Ziyi Li,Tangtang Yang et al.
Long Qian et al.
Colorectal cancer (CRC) is a common malignancy in clinical practice, and its treatment is greatly challenged by tumor heterogeneity. The most prominent features of CRC heterogeneity are differences in metabolic states and genomic instabilit...
Potential neuroprotective role of dexmedetomidine in preventing postoperative cerebral hyperperfusion syndrome: from mechanisms to clinical applications [0.03%]
右美托咪定在防治术后脑高灌注综合征中的潜在神经保护作用：从机制到临床应用研究
Yujing Feng,Rong Bao,Lili Huang et al.
Yujing Feng et al.
Cerebral hyperperfusion syndrome (CHS) is an uncommon but serious problem that can occur following carotid endarterectomy, carotid artery stenting, and revascularization procedures for moyamoya disease (MMD). Clinically, CHS can lead to cer...
Case report of durable responders to sintilimab plus second-line chemotherapy in relapsed/refractory angioimmunoblastic T-cell lymphoma [0.03%]
sintilimab联合二线化疗治疗复发/难治血管免疫母T细胞淋巴瘤的两例长期生存患者报告
Wensi Zhao,Xiang Cheng
Wensi Zhao
Angioimmunoblastic T-cell lymphoma (AITL) is a highly aggressive lymphoma characterized by complex and unique clinicopathological and biological features, as well as a generally poor prognosis. First-line treatment typically consists of ant...
5-ALA-PDT combined with oral Kangfuxin solution improves HR-HPV outcomes, vaginal microecology and quality of life in patients with HPV-positive cervical erosion [0.03%]
5-氨基乙酰丙酸光动力疗法联合口服康妇炎胶囊治疗人乳头瘤病毒阳性宫颈糜烂的临床研究
Yake Gao,Mei Qiao,Jinfeng Guo et al.
Yake Gao et al.
Objective: To evaluate the efficacy, safety, and effects on related indicators of 5-aminolevulinic acid-mediated photodynamic therapy (5-ALA-PDT) combined with oral Kangfuxin liquid in patients with human papillomavirus (...
Combined therapy with vitamin D, mesalazine, and microecological preparations improves clinical outcome in ulcerative colitis [0.03%]
维生素D、美沙拉嗪联合微生态制剂治疗溃疡性结肠炎的临床研究
Jiancheng Xu,Kundong Wu,Na Wang et al.
Jiancheng Xu et al.
Objective: To evaluate the clinical efficacy of adjunctive vitamin D to mesalazine combined with microecological preparations in the treatment of ulcerative colitis. ...