Use of sentinel lymph node biopsy to select patients for local-regional therapy after neoadjuvant chemotherapy [0.03%]
新辅助化疗后选择局部区域治疗患者的示踪淋巴结活检法的应用
Lillian M Erdahl,Judy C Boughey
Lillian M Erdahl
Use of sentinel lymph node biopsy for axillary staging of patients with breast cancer treated with neoadjuvant chemotherapy has been widely debated. Questions arise regarding the accuracy of sentinel lymph node biopsy in axillary staging fo...
Risk of Ipsilateral and Contralateral Cancer in BRCA Mutation Carriers with Breast Cancer [0.03%]
BRCA基因突变型乳腺癌患者同侧和对侧患癌风险
Leila Green,Funda Meric-Bernstam
Leila Green
BRCA1 and BRCA2 mutation carriers with breast cancer have a high risk of ipsilateral breast cancer tumor recurrence (IBTR) and a high lifetime risk of contralateral breast cancer (CBC). The IBTR risk is significantly higher in women who ele...
Fanny Le Du,Naoto T Ueno,Ana M Gonzalez-Angulo
Fanny Le Du
Breast cancer is a heterogeneous disease. For the past decades, new technical tools have been developed for biomarkers at the DNA, RNA and protein levels to better understand the biology of breast cancer. This progress is essential to class...
Jasmine A McDonald,Abhishek Goyal,Mary Beth Terry
Jasmine A McDonald
Moderate alcohol consumption has been linked to an approximate 30-50% increased risk in breast cancer. Case-control and cohort studies have consistently observed this modest increase. We highlight recent evidence from molecular epidemiologi...
Omega-3 fatty acids for the prevention of breast cancer: an update and state of the science [0.03%]
预防乳腺癌的欧米伽3脂肪酸研究进展及科学现状
Neil M Iyengar,Clifford A Hudis,Ayca Gucalp
Neil M Iyengar
The quantity and makeup of dietary fat intake are known to impact human health. Use of Omega-3 (ω-3) polyunsaturated fatty acid (PUFA) supplements has gained increasing attention for a variety of purported health benefits, including cancer...
Cesar A Santa-Maria,Vered Stearns
Cesar A Santa-Maria
Given the high incidence, morbidity and mortality associated with breast cancer, developing effective chemopreventive strategies is crucial. Clinicians must carefully identify both populations at risk who would benefit from chemoprevention,...
Laura Reimers,Katherine D Crew
Laura Reimers
Clinical trial data on selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) have demonstrated reduced breast cancer incidence in the prevention setting among high-risk women. We conducted an extensive review of clin...
Chemotherapy in Patients with Anthracycline- and Taxane-Pretreated Metastatic Breast Cancer: An Overview [0.03%]
蒽环类和紫杉烷类药物辅助治疗后的转移性乳腺癌患者进行化疗的综述分析
Eleni Andreopoulou,Joseph A Sparano
Eleni Andreopoulou
Anthracyclines and taxanes are cytotoxic agents that are commonly used for the treatment of breast cancer, including in the adjuvant, neoadjuvant, and metastatic setting. Each drug class of is associated with cumulative and potentially irre...
Erin Currin,Hannah M Linden,David A Mankoff
Erin Currin
The estrogen receptor (ER) is expressed on the vast majority of newly diagnosed breast cancers, yet not all ER-positive tumors will respond to endocrine therapy. Selecting patients for endocrine therapy can be considered as a series of pred...
Maryam B Lustberg,Bhuvaneswari Ramaswamy
Maryam B Lustberg
Breast carcinogenesis is a multistep process involving both genetic and epigenetic changes. Epigenetics is defined as reversible changes in gene expression, not accompanied by alteration in gene sequence. DNA methylation, histone modificati...