Comparison of Random Periareolar Fine Needle Aspirate versus Ductal Lavage for Risk Assessment and Prevention of Breast Cancer [0.03%]
乳腺癌风险评估和预防的随机检测对比：乳房周围细针抽吸与导管灌洗
Abigail Hoffman,Rod Pellenberg,Catherine Ibarra Drendall et al.
Abigail Hoffman et al.
Random periareolar fine needle aspiration (RPFNA) and ductal lavage (DL) are research techniques developed to (1) assess short-term breast cancer risk in asymptomatic women who are at increased risk for breast cancer and (2) track cytologic...
Nicholas P Tobin,Jonas Bergh
Nicholas P Tobin
The oncogenic capabilities of the cell cycle protein cyclin D1 have long been established in a breast cancer setting. The CCND1 gene is amplified in up to 15 % of breast tumors, with overexpression of its corresponding protein found in up t...
Rachel A Freedman,Carey K Anders
Rachel A Freedman
Approximately 10% to 15% of women with metastatic breast cancer will develop brain metastases. Treatment options for these women remain limited, particularly at the time of central nervous system (CNS) relapse following completion of initia...
Shaveta Vinayak,James M Ford
Shaveta Vinayak
Poly (ADP-ribose) polymerase (PARP) inhibitors, a novel class of drugs that target tumors with DNA repair defects, have received tremendous enthusiasm. Early preclinical studies identified BRCA1 and BRCA2 tumors to be highly sensitive to PA...
Statins May Reduce Breast Cancer Risk, Particularly Hormone Receptor-Negative Disease [0.03%]
他汀类药物可能降低乳腺癌风险尤其是激素受体阴性的疾病风险
Shaveta Vinayak,Allison W Kurian
Shaveta Vinayak
Estrogen and progesterone receptor-negative breast cancer disproportionately affects young women and African Americans, has a poor prognosis, and lacks an effective chemoprevention agent. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) redu...
Metabolic Syndrome and Breast Cancer Risk: Is There a Role for Metformin? [0.03%]
代谢综合征与乳腺癌风险：二甲双胍会发挥作用吗？
Catherine Ibarra-Drendall,Eric C Dietze,Victoria L Seewaldt
Catherine Ibarra-Drendall
Obesity is one of the most important known preventable causes of cancer, accounting for up to 20% of cancer deaths in women. Obese women have increased risk of dying from breast cancer as well as an increased risk of distant metastasis. Met...
Mathematical Oncology: How Are the Mathematical and Physical Sciences Contributing to the War on Breast Cancer? [0.03%]
数学肿瘤学：数学和物理科学如何助力抗击乳腺癌？
Arnaud H Chauviere,Haralampos Hatzikirou,John S Lowengrub et al.
Arnaud H Chauviere et al.
Mathematical modeling has recently been added as a tool in the fight against cancer. The field of mathematical oncology has received great attention and increased enormously, but over-optimistic estimations about its ability have created un...
Meghan Flanagan,Susan Love,E Shelley Hwang
Meghan Flanagan
The intraductal approach is particularly appealing in the setting of ductal carcinoma in situ (DCIS), a preinvasive breast neoplasm that is thought to be entirely intraductal in its extent. Based on an emerging understanding of the anatomy ...