Viral and transgenic reporters and genetic analysis of adult neurogenesis [0.03%]
病毒和转基因报告系统及成人神经发生遗传学分析
Grigori Enikolopov,Linda Overstreet-Wadiche,Shaoyu Ge
Grigori Enikolopov
Stem and progenitor cells of the developing and adult brain can be effectively identified and manipulated using reporter genes, introduced into transgenic reporter mouse lines or recombinant viruses. Such reporters rely on an ever-increasin...
Wolf-Dietrich Heyer
Wolf-Dietrich Heyer
Recombination is a central process to stably maintain and transmit a genome through somatic cell divisions and to new generations. Hence, recombination needs to be coordinated with other events occurring on the DNA template, such as DNA rep...
Peter Devreotes,Alan Rick Horwitz
Peter Devreotes
Stimuli that promote cell migration, such as chemokines, cytokines, and growth factors in metazoans and cyclic AMP in Dictyostelium, activate signaling pathways that control organization of the actin cytoskeleton and adhesion complexes. The...
Iswar K Hariharan,David B Wake,Marvalee H Wake
Iswar K Hariharan
Although we are used to the idea that many organisms stop growing when they reach a predictable size, in many taxa, growth occurs throughout the life of an organism, a phenomenon referred to as indeterminate growth. Our comparative analysis...
Alfredo I Penzo-Méndez,Ben Z Stanger
Alfredo I Penzo-Méndez
The control of organism and organ size is a central question in biology. Despite the attention it has received, our understanding of how adult organ size is determined and maintained is still incomplete. Early work has shown that both auton...
Microglia Function in Central Nervous System Development and Plasticity [0.03%]
小胶质细胞在中枢神经系统发育和可塑性中的功能
Dorothy P Schafer,Beth Stevens
Dorothy P Schafer
The nervous system comprises a remarkably diverse and complex network of different cell types, which must communicate with one another with speed, reliability, and precision. Thus, the developmental patterning and maintenance of these cell ...
Craig H Bailey,Eric R Kandel,Kristen M Harris
Craig H Bailey
Consolidation of implicit memory in the invertebrate Aplysia and explicit memory in the mammalian hippocampus are associated with remodeling and growth of preexisting synapses and the formation of new synapses. Here, we compare and contrast...
Molecular Genetic Strategies in the Study of Corticohippocampal Circuits [0.03%]
分子遗传学在皮层-海马环路研究中的应用策略
Christopher C Angelakos,Ted Abel
Christopher C Angelakos
The first reproductively viable genetically modified mice were created in 1982 by Richard Palmiter and Ralph Brinster (Palmiter RD, Brinster RL, Hammer RE, Trumbauer ME, Rosenfeld MG, Birnberg NC, Evans RM. 1982. Dramatic growth of mice tha...
James F Gillooly,Andrew Hein,Rachel Damiani
James F Gillooly
Variation in the size of cells, and the DNA they contain, is a basic feature of multicellular organisms that affects countless aspects of their structure and function. Within humans, cell size is known to vary by several orders of magnitude...
Olaf Bergmann,Kirsty L Spalding,Jonas Frisén
Olaf Bergmann
Adult neurogenesis appears very well conserved among mammals. It was, however, not until recently that quantitative data on the extent of this process became available in humans, largely because of methodological challenges to study this pr...