Cell-Size Control [0.03%]
细胞大小控制
Amanda A Amodeo,Jan M Skotheim
Amanda A Amodeo
Cells of a given type maintain a characteristic cell size to function efficiently in their ecological or organismal context. They achieve this through the regulation of growth rates or by actively sensing size and coupling this signal to ce...
Rachel Lockridge Mueller
Rachel Lockridge Mueller
Cell size is highly variable among different species across the Tree of Life. For decades, biologists have generated hypotheses to explain this variation, in many cases, drawing on the correlations that exist among cell size, genome size, n...
Patrick H O&#x;Farrell
Patrick H O&#x;Farrell
A requirement that an animal be able to feed to grow constrains how a cell can grow into an animal, and it forces an alternation between growth (increase in mass) and proliferation (increase in cell number). A growth-only phase that transfo...
Simone Reber,Nathan W Goehring
Simone Reber
Organelle function is often directly related to organelle size. However, it is not necessarily absolute size but the organelle-to-cell-size ratio that is critical. Larger cells generally have increased metabolic demands, must segregate DNA ...
Memory consolidation [0.03%]
记忆巩固
Larry R Squire,Lisa Genzel,John T Wixted et al.
Larry R Squire et al.
Conscious memory for a new experience is initially dependent on information stored in both the hippocampus and neocortex. Systems consolidation is the process by which the hippocampus guides the reorganization of the information stored in t...
Ann M Graybiel,Scott T Grafton
Ann M Graybiel
After more than a century of work concentrating on the motor functions of the basal ganglia, new ideas have emerged, suggesting that the basal ganglia also have major functions in relation to learning habits and acquiring motor skills. We r...
Robert Martienssen,Danesh Moazed
Robert Martienssen
The involvement of RNA interference (RNAi) in heterochromatin formation has become clear largely through studies in the fission yeast Schizosaccharomyces pombe and plants like Arabidopsis thaliana. This article discusses how heterochromatic...
Hjördis Czesnick,Michael Lenhard
Hjördis Czesnick
To achieve optimal functionality, plant organs like leaves and petals have to grow to a certain size. Beginning with a limited number of undifferentiated cells, the final size of an organ is attained by a complex interplay of cell prolifera...
The opposing actions of target of rapamycin and AMP-activated protein kinase in cell growth control [0.03%]
雷帕霉素靶蛋白与AMP活化蛋白激酶在细胞生长调控中的拮抗作用
Sravanth K Hindupur,Asier González,Michael N Hall
Sravanth K Hindupur
Cell growth is a highly regulated, plastic process. Its control involves balancing positive regulation of anabolic processes with negative regulation of catabolic processes. Although target of rapamycin (TOR) is a major promoter of growth i...
Functional differentiation of adult-born neurons along the septotemporal axis of the dentate gyrus [0.03%]
海马dentate gyrus区Septo-temporal梯度新生神经元的功能分化
Melody V Wu,Amar Sahay,Ronald S Duman et al.
Melody V Wu et al.
Over the past several decades, the proliferation and integration of adult-born neurons into existing hippocampal circuitry has been implicated in a wide range of behaviors, including novelty recognition, pattern separation, spatial learning...